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|CAS:||94-24-6||Synonyms:||Amethocaine ; Anetain|
|Chemical name||2-(Dimethylamino)ethyl 4-(butylamino)benzoate; 2-
; Amethocaine; Anetain
|Appearance||White crystalline powder|
|Packing||Discreet packing ways as your requirement, 100% go
|Storage||Store in cool and dry area and keep away from direct
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine, also known as amethocaine, is a local anesthetic used to numb the eyes, nose, or throat. Tetracaine may also be used before starting an intravenous to decrease pain from the procedure. Typically it is applied as a liquid to the area. Onset of effects when used in the eyes is within 30 seconds and last for less than 15 minutes.
Tetracaine was patented in 1930 and came into medical use in 1941. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 1.34 to 1.63 USD per 10 ml bottle. In the United Kingdom the eye drops cost the NHS about 0.49 pounds per dose.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
A systematic review investigated tetracaine for use in emergency departments, especially for starting intravenous lines in children, in view of its analgesic and cost-saving properties. However, Tetracaine did not find an improvement in first-attempt cannulations.
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
|Description||White or light yellow, waxy solid||Complies|
|Identification||A. Dissolve 100 mg in 10 mL of dilut hydrochloric acid(1 in 120), and add 1 mL of potassium thiocyanate
Solution (1 in 4): A crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: It melts between 130 and 132.
|B: By UV, To match with working standard||Complies|
|Chromatographic purity||Conform to standard||Complies|
|Loss on drying||≤0.5%||0.09%|
|Resiue on ignition||≤0.1%||0.03%|
|Conclusion||The Sample Complies With Specification of USP38|
Tetracaine is given as an injection through a needle placed into an area of your middle or lower back near your spine. You will receive this injection in a hospital setting. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving tetracaine injection. Spinal numbing medicines can have long-lasting effects on certain body processes such as sexual function, bowel or bladder control, and movement or feeling in your legs or feet. Talk with your doctor about these effects. Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. Since tetracaine is given as needed before a surgery or other medical procedure, you are not likely to be on a dosing schedule.
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