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Local anesthetic; Mainly used in mucosa anesthetic.
Tetracaine Hydrochloride is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
1) Tetracaine Hcl For block anesthesia and epidural anesthesia.
2) Tetracaine Hcl used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
3) Tetracaine Hcl As painkillers of injection in the medicament.
4) Tetracaine Hcl used in suppository and ointment preparation,
5) Tetracaine Hcl has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the Function of calcium release channels (ryanodine receptors) that control the release of calcium from
6) Tetracaine is an allosteric blocker of channel function.At low concentrations, Tetracaine causes an initial inhibition of spontaneous calcium release events, while at high Concentrations, tetracaine blocks release completely.
Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia. A crystalline compound related to procaine and used as a local anesthetic.
|Test Items||Specification||Test Results|
|Appearance||Fine, white, crystalline, odorless powder||confirm|
|Identification||ABC in Pass||confirm|
|Solubility||Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene||confirm|
|USP Reference standards||USP Tetracaine Hydrochloride RS. USP Endotoxin RS.||confirm|
|Melting point||145~150 degree||146.0~147.5
|Chromatographic purity||In Pass||confirm|
|Related substance||Not more than the reference solution 0.05%||confirm|
|Residue on ignition||≤0.10%||0.05%|
|Loss on Drying||≤ 0.5%||0.19%|
|Conclusion||Confirms USP 32|
Used for mucosal epidermal anesthesia, nerve tissue anesthesia, epidural anesthesia and Subarachnoid space anesthesia. In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.
Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours. Parenteral administration of Tetracaine hydrochloride stabilizes the neuronal membrane and prevents initiation and transmission of nerve impulses thereby effecting local anesthesia. The onset of action is rapid, and the duration is prolonged (up to two or three hours or longer of surgical anesthesia).Tetracaine hydrochloride is detoxified by plasma esterases to aminobenzoic acid and diethylaminoethanol.
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