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CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder

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CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder

China CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder supplier
CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder supplier CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder supplier

Large Image :  CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder

Product Details:

Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 84057-84-1

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Minimum Order Quantity: 10g
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Detailed Product Description
Product Name: Lamotrigine CAS: 84057-84-1
MF: C9H7Cl2N5 MW: 256.09
EINECS: 281-901-8 Appearance: White To Cream Coloured Powder

Antiepileptic Pharmaceutical Raw Materials Lamotrigine CAS 84057-84-1 For Treatment of Epilepsy And Bipolar Disorder

 

Product Name: Lamotrigine
 

Product Details:

 

 

Product Name

 

Lamotrigine 
Synonyms

4-Triazine-3,5-Diamine,6-(2,3-Dichlorophenyl)-2;

3,5-Diamino-6-(2,3-Dichlorophenyl)-1,2,4-Triazine;

6-(2,3-Dichlorophenyl)-1,2,4-Triazine-3,5-Diamine;Lamictal;Lamotrigin

 

CAS 

 

84057-84-1

 

MF

 

C9H7Cl2N5

 

MW

 

256.09

 

EINECS

 

281-901-8

 

Chemical Properties

 

White to Cream Coloured Powder

 

Category

 

API

 

Melting point

 

177-181ºC

 

Quality Standard

 

EP/USP

 

Place Of Origin

 

China

 

Application

 

Pharmaceutical raw materials

 

 

Description:

 

Lamotrigine, originally marketed as Lamictal and available under many brands worldwide, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression.
For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type II.

Lamotrigine is a synthetic phenyltriazine with anti-epileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake.
It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver .

 

 

Application:

 

For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
Biological Activity:Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na + , K + and Ca 2+ currents.


Lamotrigine Medical uses
Epilepsy
Lamotrigine is approved in the US for the treatment of partial seizures. It is considered a first-line drug for primary generalised tonic-clonic seizures (includes simple partial, complex partial and secondarily generalised seizures), and as an adjuvant therapy in partial seizures (focal onset tonic-clonic, atypical absence, myoclonic, and due to Lennox-Gastaut syndrome). As well, it is used as an alternative drug for absence seizure and atypical absence, myoclonic, and atonic seizures.
Lamotrigine is one of a small number of FDA-approved therapies for seizures associated with Lennox-Gastaut syndrome, a severe form of epilepsy. Typically developing before four years of age, LGS is associated with developmental delays. There is no cure, treatment is often complicated, and complete recovery is rare. Symptoms include the atonic seizure (also known as a "drop attack"), during which brief loss of muscle tone and consciousness cause abrupt falls. Lamotrigine significantly reduces the frequency of LGS seizures, and is one of two medications known to decrease the severity of drop attacks.Combination with valproate is common, but this increases the risk of lamotrigine-induced rash, and necessitates reduced dosing due to the interaction of these drugs.

Bipolar disorder
Lamotrigine is approved in the US for maintenance treatment of bipolar I disorder. While traditional anticonvulsant drugs are predominantly antimanics, lamotrigine is most effective for preventing the recurrent depressive episodes of bipolar disorder. The drug seems ineffective in the maintenance of current rapid-cycling, acute mania, or acute depression in bipolar disorder; however, it is effective at prevention of or delaying the mania, depressive, or rapid cycle. According to studies in 2007, lamotrigine may treat bipolar depression without triggering mania, hypomania, mixed states, or rapid-cycling.

 

 

COA:

 

 

Item

 

Requirements Test Results

 

Description

 

A white or almost white crystalline powder Complies
Solubility Soluble in methanol, very slightly soluble in acetone and isopropanol . Complies

 

Melting point

 

215°C~ 219°C 217°C~218°C

 

Appearance of solution

 

5.0% solution in DMF should be clear Complies

 

Loss on drying

 

≤ 0.5% 0.03%

 

Residue on ignition

 

≤ 0.1% 0.04%

 

Heavy metals

 

≤ 20ppm Complies

 

Residual solvent

 

   

 

Methanol

 

≤ 1000ppm Complies

 

Ethanol

 

≤ 1000ppm Complies

 

Any other individual impurity:

≤ 0.1% Complies

 

Total impurities

 

≤ 1.0% Complies

 

Assay

 

99.0%-101.0% 99.70%

 

Conclusion

 

Meets the Requirements

 

 

CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder

 

Our Company Advantages:

 

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

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Name Purity
Methylamine 40% water solution
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Hydrogen bromide 48% water solution
(-)-Dibenzoyl-L-tartaric acid monohydrate NLT 99%
Potassium borohydride NLT 97%
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Pramipexole Hydrochloride NLT 99%
Albuterol sulfate NLT 99%
Dextromethorphan hydrobromide DXM NLT 99%
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Armodafinil NLT 99%
PHENIBUT NLT 99%
Suvorexant (MK-4305) NLT 99%
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Mirtazapine NLT 99%
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Paroxetine hydrochloride NLT 99%
Fluoxetine hydrochloride NLT 99%
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Vortioxetine hydrobromide NLT 99%
Vortioxetine NLT 99%
Tianeptine NLT 99%
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gamma-butyrolactone (GBL) NLT 99.5%
5a-Hydroxy Laxogenin NLT 98%
 

 

 

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Boldenone Acetate

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Boldenone Propionate

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CAS:106505-90-2

Boldenone Cypionate

Trenbolone Steroid

 

 

22

CAS:10161-33-8

Trenbolone base

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24

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Nandrolone Steroid

 

 

26

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Nandrolone cypionate

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Nandrolone decanoate(DECA)/ Deca durabolin

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Nandrolone Undecylate

31

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Nandrolone propionate

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32

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Methenolone Acetate(Primobolan)

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Methenolone enanthate (USAN)

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Metenolone

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