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Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder

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Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder

China Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder supplier
Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder supplier Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder supplier

Large Image :  Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder

Product Details:

Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 443913-73-3

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
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Detailed Product Description
Product Name: Vandetanib CAS: 443913-73-3
MF: C9H7Cl2N5 MW: 256.09
EINECS: 281-901-8 Appearance: White To Cream Coloured Powder

High Quality Pharmaceutical Raw Powder Vandetanib CAS443913-73-3 Oral Inhibitor of Vascular for Anti-Cancer

 

Product Name: Vandetanib

 

Product Details:

 

 

Product Name

 

 

Vandetanib

Synonyms

VANDETANIB;4-Quinazolinamine,

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;

Vandetanib for research;

4-(4-Bromo-2-fluoroanilino)-6-methoxy- 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;N-(4-Bromo-2-fluorophenyl)

-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;

Zactima;ZD 6474;7-((4-aminocyclohexyl)

methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

 

CAS

 

 

443913-73-3

 

Assay

 

 

98%

 

MF

 

 

C22H24BrFN4O2

 

MW

 

 

475.35

 

Mol File

 

 

443913-73-3.mol

 

Density

 

 

1.406

 

Appearance

 

 

Yellow Solid

 

Usage

Vandetanib is a once-daily oral inhibitor of vascular endothelial growth

factor receptor-2 and epidermal growth factor receptor kinase activity.

The activity of Vandetanib plus Docetaxel was assessed in patients with

previously treated non-small-cell lung cancer (NSCLC).

 

Product Categories

 

Aromatics Compounds;Aromatics;Heterocycles;Inhibitors;Intermediates &

Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;ZD6474

 

 

Description:

 

Vandetanib is a kind of small molecule multi-targeted tyrosine kinase inhibitor studied and developed by the British AstraZeneca Company. In April 2011, it was approved the US FDA for entering into market under the trade name Zactima. The drug, as a tablet, can be applied to the treatment of advanced medullary thyroid cancer of adult patients.

Vandetanib is a multi-targeted tyrosine kinase inhibitor, and belongs to the Anilinoquinazoline compounds, called "second generation Iressa". It not only acts on the tumor cells, EGFR, VEGFR and RET tyrosine kinases, but can also inhibit other kind of tyrosine kinases and serine / threonine kinases. Vandetanib is the first approved drugs approved for treatment of medullary thyroid carcinoma. It is suitable for treating unresectable, locally advanced or metastatic-symptoms or progressive medullary thyroid carcinoma. A randomized, placebo-controlled clinical trial results have showed that vandetanib can significantly delay the progression time of locally advanced or metastatic medullary thyroid cancer. The recommended daily dose is 300 mg (oral), when the patient exhibits tolerance to drugs or being not able to tolerate the toxicity, they should stop treatment immediately. Those most common adverse reactions of this medicine include diarrhea, rash, acne, nausea, hypertension, headache, fatigue, loss of appetite and abdominal pain.

The adverse reactions is dose-related; at <300 mg/d, the patient has a well tolerance with the maximum tolerated dose (MTD) being 300mg. There are many kinds disease types contained in the phase clinical study. The NSCLC clinical trials of vandetanib are currently under way for China.British AstraZeneca Company, in May 2001 and October 2001, respectively, had obtained preferential access to the world's patent (WO2001032651, WO 2001074360) and applied corresponding protection on the formula, synthesis methods and pharmaceutical compositions of these compounds (including bonus salt). Vandetanib can inhibit the development of medullary thyroid carcinoma, and is the first FDA-approved drug for the treatment of the disease and will provide support for the treatment of advanced medullary thyroid cancer in adult patients. Vandetanib (INN, trade name Caprelsa) is an anti-cancer drug that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor(EGFR), and the RET-tyrosine kinase.

 

 

Applications:

 

Vandetanib is used to treat a certain type of thyroid cancer that cannot be treated by surgery or that has spread to other parts of the body. Vandetanib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).

 

Vandetanib was the first drug to be approved by FDA (April 2011) for treatment of late-stage (metastatic) medullary thyroid cancer in adult patients who are ineligible for surgery. Vandetanib was first initially marketed without a trade name, and is being marketed under the trade name Caprelsa since August 2011. Vandetanib is a type of biological therapy. It is a cancer growth blocker, which stops signals (chemical messengers) that cancer cells use to divide and grow. An anticancer drug that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. Vandetanib is an orally active small molecule tyrosine kinase inhibitor (TKI) with activity against several pathways implicated in malignancy including the vascular endothelial growth factor receptor pathway, the epidermal growth factor receptor pathway, the platelet derived growth factor receptor pathway, and REarranged during Transfection pathway.

 

Vandetanib CAS: 443913-73-3 Pharmaceutical Industry Raw Materials Anti - Cancer Cream Coloured Powder

 

 

Our Company Advantages:

 

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

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Pharmaceutical Raw Materials

 

Name

Purity

Methylamine

40% water solution

Methylamine hydrochloride

NLT 99%

Benzeneacetonitrile (benzyl cyanide)

NLT 99%

Propiophenone

NLT 99.5%

Hydrogen bromide

48% water solution

(-)-Dibenzoyl-L-tartaric acid monohydrate

NLT 99%

Potassium borohydride

NLT 97%

Sodium borohydride

NLT 98%

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (CAS No:43200-81-3)

NLT 99%

N-PHENYLPIPERIDIN-4-AMINE DIHYDROCHLORIDE (4-ANP) CAS 99918-43-1

NLT 99%

Pramipexole Hydrochloride

NLT 99%

Albuterol sulfate

NLT 99%

Dextromethorphan hydrobromide DXM

NLT 99%

Dimethocaine

NLT 99%

Dermorphin

10mg/vial

Sunifiram DM-235

NLT 99%

Adrafinil

NLT 99%

Armodafinil

NLT 99%

PHENIBUT

NLT 99%

Suvorexant (MK-4305)

NLT 99%

Hetlioz (tasimelteon)

NLT 99%

Amitriptyline hydrochloride

NLT 99%

Mirtazapine

NLT 99%

Trazodone hydrochloride

NLT 99%

Venlafaxine hydrochloride

NLT 99%

Bupropion hydrochloride

NLT 99%

Sertraline hydrochloride

NLT 99%

N-Methylparoxetine

NLT 99%

Paroxetine hydrochloride

NLT 99%

Fluoxetine hydrochloride

NLT 99%

Citalopram hydrobromide

NLT 99%

Vortioxetine hydrobromide

NLT 99%

Vortioxetine

NLT 99%

Tianeptine

NLT 99%

5-Hydroxytryptophan 5-HTP

NLT 98%

gamma-butyrolactone (GBL)

NLT 99.5%

5a-Hydroxy Laxogenin

NLT 98%

 

 

Steroid Series

 

Testosterone Steroid

 

 

No.

CAS NO

Name

1

CAS:58-22-0

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Boldenone

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Trenbolone Steroid

 

 

22

CAS:10161-33-8

Trenbolone base

23

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Trenbolone acetate(Finaplix H/Revalor-H)

24

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Trenbolone enanthate(parabolan)

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Trenbolone Hexahydrobenzyl Carbonate

Nandrolone Steroid

 

 

26

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Nandrolone

27

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Nandrolone Phenypropionate (NPP)/durabolin

28

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Nandrolone cypionate

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