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99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug

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99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug

China 99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug supplier
99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug supplier 99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug supplier

Large Image :  99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug

Product Details:

Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS:136434-34-9

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
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Detailed Product Description
Product Name: Duloxetine Hydrochloride Synonyms: S)-DULOXETINE HYDROCHLORIDE
CAS: 136434-34-9 MF: C18H20ClNOS
MW: 333.88 Appearance: White Crystalline Solid

Pharmaceutical Raw Materials Duloxetine Hydrochloride CAS 136434 - 34 - 9

 

Product Name: Duloxetine hydrochloride

 

Product Details:

 

 

Product name

 

Duloxetine hydrochloride

Synonyms

S)-DULOXETINE HYDROCHLORIDE;L248686;DULOXETINE HCL;(S)-DULOXETINE HYDROCHLORIDE;LY-248686;DULOXETINE HCL;DULOXETINE HYDROCHLORIDE;N-methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine, hydrochloride;(RS)Duloxetine HCl;(+)-(S)-N-Methyl-g-(1-naphthyloxy)-2-thiophenepropylamine;(gS)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine

 

CAS

 

136434-34-9

 

EINECS

 

200-659-6

 

MF

 

C18H20ClNOS

 

MW

 

333.88

 

Mol File

 

136434-34-9.mol

 

MP

 

118-122°C

 

Certification

 

ISO9001

 

Appearance

 

White Crystalline Solid

 

Storage Temp

 

-20°C Freezer

 

Usage

 

having antidepressant effect, while also having inhibitory effect on the central pain

 

 

Description:

 

Duloxetine Hydrochloride is the hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors.

Duloxetine hydrochloride is a new kind of selective dual inhibitor of 5 hydroxy trptamine (5-HT) and norepinephrine reuptake, and thus having antidepressant effect, while also having inhibitory effect on the central pain. Its pharmacological characteristic is being able to inhibit neuronal pre-synaptic membrane's reuptake on 5-hydroxy trptamine and norepinephrine but instead have a low inhibitory effect on the reuptake of dopamine. Duloxetine hydrochloride is indicated for depression and it is effective in treating both endogenous and non-endogenous depression as well as the feeling of pain associated with depression. It has a therapeutic dose of 60mg/d~120mg/d with a good security and fewer adverse reactions with common adverse reactions such as nausea, dry mouth, constipation, poor appetite, fatigue, sleepiness, and increased sweating. Another indication is the pain caused by diabetic neuropathy.

 

 

Application:


1. Labelled Duloxetine, which is used as an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI).
2. An antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence.
3. leucotriene antagonist, antiasthmatic
4. anti-depressant, analgesic for osteoarthiritis and musculoskeletal pain
5. solubility H2O: soluble5 mg/mL (clear solution, warmed)

Duloxetine HCL is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

 

 

COA:

 

 

Product name

 

Duloxetine HCL

 

CAS

 

136434-34-9

Outer Packing

1KG foil bag

 

Standard adopted

 

Enterprise Standard

 

Items of analysis

 

Specification

Results

 

Description

 

White or off- white crystalline powder

White crystalline powder

 

Loss on drying (%)

 

Not more than 0.5%

0.20%

 

Melting Point

 

160.0~165.0℃

162.7~163.3

 

Specific Rotation

 

+115.0~+125.0°

+117.8°

 

Heavy metals

 

≤0.001%

<0.001%

 

Purity(HPLC)

 

Single impurity≤0.5%

0.20%

 

Assay by HPLC(A%)

 

Not less than 98.0%

99.50%

 

Conclusion

 

Qualified

 

 

 

99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug

 

Our Company Advantages:

 

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!


3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

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