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Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections

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Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections

China Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections supplier
Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections supplier Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections supplier

Large Image :  Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections

Product Details:

Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 84625-61-6

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
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Detailed Product Description
Product Name: Itraconazole Other Name: METOCLOPRAMIDE HYDROCHLORIDE
CAS: 84625-61-6 MF: C35H38Cl2N8O4
MW: 705.63 Appearance: White Crystals

Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections

 

Product Name: Itraconazole

 

Product Details:

 

 

Product name

 

Itraconazole

Synonyms

2-Butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl methyl)-1,

3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,

4-triazol-3-one; Oriconazole; Sporanox

Other Name

METOCLOPRAMIDE HYDROCHLORIDE, MONOHYDRATE;GastreseL.A;Gastrobidcontinus;

METOCLOPRAMIDEHYDROCHLORIDE,

MONOHYDRATE,USP;Gastromax;4-Amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride;Metoclopramide hydrochloride;Benzamide,

4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate;

 

Original

 

China

 

CAS

 

84625-61-6

 

MF

 

C35H38Cl2N8O4

 

MW

 

705.63

 

Purity

 

99%

 

Appearance

 

White crystals

 

Certification

 

SGS, ISO 9001, KOSHER

Usage

it can be used for the treatment of systemic fungal infections,

such as aspergillosis, candidiasis, cryptococcosis (including cryptococcal meningitis), histoplasmosis, sporotrichosis, Paracoccidioides brasiliensis disease

Molecular structure

Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections

 

 

Description:

 

Itraconazole is an artificially synthetic clotrimazole, being a broad-spectrum synthetic antifungal agent. Its antimicrobial spectrum and antimicrobial mechanism is similar to clotrimazole, but has strong antibacterial activity against Aspergillus.

It exerts its anti-fungal effect through changing the fungal cell membrane permeability with antibacterial activity against superficial and deep fungal pathogens. Its antibacterial spectrum is broader and stronger than ketoconazole, being able to inhibit the ergosterol synthesis of fungal cell membrane, thus playing the antifungal effect.

 

This product is suitable for the treatment of Dermatophytes (Trichophyton, Microsporum, Flocculent Epidermophyton), Yeast [Cryptococcus neoformans, Pityrosporum, Candida (including Candida albicans, Candida glabrata and candida krusei)], Aspergillus, Histoplasma, Paracoccidioides brasiliensis, Sporothrix schenckii, Hormodendrum, Cladosporium, Blastomyces dermatitidis and various kinds of other types of yeasts and fungi. Itraconazole is not able to inhibit the growth of Rhizopus and Mucor.

 

 

Application:

 

1) Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus which fluconazole is not.

2) It is also prescribed for systemic infections, such as aspergillosis, candidiasis, and cryptococcosis

3) Itraconazole has also recently been explored as an anticancer agent for patients with basal cell carcinoma.

 

The imidazole antifungal agents for the triazole ring, through inhibiting the activation of cytochrome P-450, including oxidase and peroxidase, disable the 14, alpha-methyl sterols to be dehydrogenated and be converted to ergosterol, so that the growth and proliferation of fungi are inhibited. They have strong lipophilicity and penetrate through the biofilm to inhibit the binding of the membrane to the fungus.

The antibacterial spectrum is similar to ketoconazole. It is effective in the treatment of superficial fungal diseases such as vaginal and oral candidiasis as well as skin mycosis. Furthermore, it is expected to become the highly-efficient and safe drugs for the treatment of deep fungal infections such as cryptococcal encephalitis (AIDS). It is used for the treatment of vulvovaginal candidiasis, pityriasis and skin fungal disease pityriasis caused by sensitive fungi.

It can be used for the synthesis of broad-spectrum azole antifungal agents for the treatment of systemic infection caused by deep fungus. It can also be used for the treatment of candidiasis and aspergillosis.

It is used for the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

 

It is anti Fungal and used in the treatment of stomach upset/ indigestion and other gastrointestinal conditions.

 

 

Dosage:

 

1. Candida vaginitis: 200mg each time, twice a day, a course of treatment for 1 day or 200mg, once the course of treatment of 3 days;

2. Tinea versicolor: 200mg each time, once a day with the course of treatment of 7 days ;

3. Dermatomycosis: 100 mg each time, once a day with the course of treatment of 15 days; high-degree keratinized area (such as foot bottom ringworm, hand tinea) need: extended treatment of 15 days;

4. Oral candidiasis: 100mg each time, once a day with the course of treatment of 15 days;

5. Fungal keratitis: 200 mg each time, once a day with the course of treatment of 21 days;

6. For some immunodeficiency patients, such as leukemia (such as leukemia), AIDs and organ transplanted patients, application of itraconazole capsules for the treatment of fungal infections can get reduced oral bioavailability; in this case, the dose can be doubled.

7. Onychomycosis: 1) shock treatment: 200 mg each time, twice per day with continuous one week as a shock treatment. For the treatment of nail infections, it is recommended to adopt two shock treatment courses with each course having a gap of 3 weeks; for the treatment of toenail infection, it is recommended to adopt three shock treatment courses. Each treatment course has a gap of 3 weeks. 2) Or adopt continuous treatment: 200 mg each time, once a day, continue for three months. This product is removed more slowly in the skin and keratin tissue than removed in the plasma. Therefore, for skin infections, 2 to 4 weeks after stopping the drug can achieve the most ideal clinical and mycological efficacy. For the treatment of onychomycosis, people can achieve the best clinical and mycological efficacy after 6 ~ 9 months of stopping the drugs.

 

Injection: during the first two days, give itraconazole injection 2 times a day, later change to once per day. Treatment protocol in Day 1 and 2: 2 times per day; adopt intravenous infusion of 200 mg itraconazole 1 hour each time. From day 3: perform once per day with intravenously infusion of 200 mg of itraconazole for 1 hour each time. The safety for intravenous administration of more than 14 days is not clear.

 

Anti-microbial agents Active Pharmaceutical Ingredients Itraconazole CAS 84625-61-6 for Systemic Fungal Infections

 

 

Our Company Advantages:

 

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

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