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|Appearance:||White Powder||Usage:||Muscle Gaining|
|Shipping Method:||EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC||Color:||White|
|Appearance:||White crystalline powder|
|Usage||pharmaceutical material, hormone.|
|Test Items||Specification||Test Results|
|Description||White or almost white powder||Complies|
|Identification||Meet the requirements||Complies|
|Loss on drying||≤0.5%||0.2%|
|Residue on ignition||≤0.1%||Complies|
|Related substances||Biggest Impurities≤0.5%||0.36%|
|Conclusion||Complies with In-house Standard
To understand how dutasteride works we must first learn about DHT. Dihydrotestosterone (DHT) is a sex steroid and androgen hormone. The enzyme 5a-reductase synthesizes DHT in the testes, hair follicles, adrenal glands, and prostate. Reductase inhibitors work by blocking the action of the enzymes that convert testosterone to DHT. This is why they work so well for protecting/re-growing head hair and helping with BPH. Dutasteride stacked with finasteride can lower DHT in the body up to 95%.
Dutasteride, along with Finasteride is a 5-alpha-Reductase inhibitor which are a group of drugs with anti-androgenic properties which inhibit the conversion of testosterone into dihydrotestosterone (DHT). This is the same chemical found in Proscar and Propecia and is used in the treatment hyperplasia and androgenic alopecia. Because these drugs reduce levels of dihydrotestosterone (DHT) they are used to prevent and treat hairloss. It is most commonly used to treat enlarged prostate glands.
Dutasteride is used alone or with another medication (tamsulosin [Flomax]) to treat benign prostatic hyperplasia. Dutasteride is used to treat symptoms of BPH and may reduce the chance of developing acute urinary retention.Dutasteride may also decrease the chance that prostate surgery will be needed.Dutasteride is in a class of medications called 5-alpha reductase inhibitors. It works by blocking the production of a natural substance that enlarges the prostate.
This medication is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It works by reducing the size of the enlarged prostate. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently (including during the middle of the night). It may also reduce the need for surgery to treat BPH
1. Prostate enlargement
Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".
2. Prostate cancer
In those who are being regularly screened, 5α-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.
3. Pattern hair loss
Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea at a dosage of 0.5 mg per day. It has been found in several studies to improve hair growth in men more rapidly and to a greater extent than 2.5 mg/day finasteride. Dutasteride has also been used off-label in the treatment of female pattern hair loss.
How Dose Dutasteride Work
Dutasteride belongs to a class of drugs called 5α-reductase inhibitors, which block the action of the 5α-reductase enzymes that convert testosterone into DHT. It is an irreversible inhibitor of all three isoforms of 5α-reductase, types I, II, and III. This is in contrast to finasteride, which is similarly an irreversible inhibitor of 5α-reductase but only inhibits the type II and III isoenzymes. As a result of this difference, dutasteride is able to achieve a reduction in circulating DHT levels of as much as 95%, whereas finasteride is only able to achieve a reduction of 70%. In spite of the differential reduction in circulating DHT levels, the two drugs decrease levels of DHT to a similar extent (approximately 85 to 90%) in the prostate gland,where the type II isoform of 5α-reductase predominates.
In addition to DHT, dutasteride prevents the 5α-reductase-mediated formation of neurosteroids such as allopregnanolone and THDOC, and 3α-androstanediol (see also neurosteroidogenesis inhibitor).These neurosteroids are potent positive allosteric modulators of the GABAA receptor and have been found to possess antidepressant, anxiolytic, and pro-sexual effects in animal research. For this reason, prevention of neurosteroid formation may be responsible for the sexual dysfunction and depression that has been associated with 5α-reductase inhibitors like dutasteride.
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