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Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder

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Good quality Nandrolone Decanoate Powder for sales
Good quality Nandrolone Decanoate Powder for sales
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Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder

China Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder supplier
Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder supplier Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder supplier Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder supplier

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Product Details:

Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 330784-47-9

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
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Detailed Product Description
Product Name: Avanafil CAS: 330784-47-9
Appearance: White Powder Usage: Male Enhancement
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White


Quick detail

Product name  Avanafil
Assay  99% 
CAS 330784-47-9
Molecular Formula C23H26ClN7O3
Molecular Weight 483.95
Melting point 150-152°C
Density 1.372
Molecular Structure Good Quality 99% Avanafil CAS: 330784-47-9
Storage condition
Refrigerator
Character White to Off-White Cyrstalline Solid.
Usage
Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.
Categories Active Pharmaceutical Ingredients; Cnbio; Erectile Dysfunction; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's.

 

COA

 

Test Items Specification Test Results
Description White or almost white crystalline powder White crystalline powder
Melting Point 191.0~193.0ºC 192ºC
Loss of drying ≤1.0% 0.5%
Heavy Metal ≤20ppm 15ppm
TLC Only one spot Only one spot
Assay ≥99.5% 99%

 

 

Application


       Avanafil occurs as white crystalline powder, molecular formula C23H26ClN7O3 and molecular weight of 483.95 and is slightly soluble in ethanol, practically insoluble in water, and soluble in 0.1 mol/L hydrochloric acid. STENDRA, for oral administration, is supplied as oval, pale yellow tablets containing 50 mg, 100 mg, or 200 mg avanafil debossed with dosage strengths. In addition to the active ingredient, avanafil, each tablet contains the following inactive ingredients: mannitol, fumaric acid, hydroxypropylcellulose, low substituted hydroxypropylcellulose, calcium carbonate, magnesium stearate, and ferric oxide yellow.


       Avanafil comes as a tablet to take by mouth. It is usually taken with or without food as needed, about 30 minutes before sexual activity. Do not take avanafil more often than once in 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take avanafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on an average dose of avanafil and may increase or decrease your dose depending on how you respond to the medication. Tell your doctor if avanafil is not working well or if you experience side effects.

 

 

Description


       Avanafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection), also know n as erectile dysfunction (ED). It is in a class of drugs called, phosphodiesterase inhibitors that also includes tadalafil (Cialis),sildenafil () and vardenafil (Levitra).Erect ion of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.

 

       Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Avanafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. Avanafil was approved by the FDA in April 2012.

 

 

 

Usage
 

       It is a development of the phosphodiesterase type 5 inhibitors, for the treatment of male sexual dysfunction, at present in the America, EU and Japan have completed phase II clinical trials, phase III clinical trials will start. The product is composed of Japanese Tanabe Pharma Company and VIVUS company development. In addition to oral dosage forms, VIVUS company is also developing Avanafil urethral administration, for not responding to oral dosage forms of patients.

 

       Avanafil is a potent, highly selective phosphodiesterase 5 inhibitor, in vitro experiments showed that the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular effects of avanafil should be weaker than.

 

       Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on blood pressure was significantly weaker than and nitrate drugs with clothes. Moreover, avanafil inhibition of phosphodiesterase 6 is very weak, the relevant visual disturbance suppression may the enzyme phosphodiesterase 5 inhibitor induced and other.

 

 

Do NOT use avanafil if:


you are allergic to any ingredient in avanafil
you have been advised by your doctor to avoid sexual activity
you have severe liver or kidney problems, or you are on dialysis
you have certain eye problems (eg, a hereditary degenerative retinal disorder, including retinitis pigmentosa)
you have certain heart problems (eg, unstable angina, angina during sexual intercourse, severe heart failure), low blood pressure, or uncontrolled high blood pressure
you have had a heart attack, stroke, life-threatening irregular heartbeat, or a certain type of heart surgery within the past 6 months

Avanafil 330784-47-9 USP Standard 99% Purity Male Enhancement PowderAvanafil 330784-47-9 USP Standard 99% Purity Male Enhancement Powder

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