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98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal

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98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal

98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal
98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal 98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal 98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal 98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal

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Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 300-08-3
Payment & Shipping Terms:
Minimum Order Quantity: 1KG
Price: 1500 USD/KG
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 30 KG/Month
Detailed Product Description
Product Name: Arecoline Hydrobromide CAS.NO: 300-08-3
MF: C8H14BrNO2 MW: 236.11
Appearance: White Powder Function: Insecticide
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                                         98% Purity Insecticide Arecoline Hydrobromide CAS 300-08-3 Used For Removing Parasites From Animal 0

 

 

Product Name: Arecoline Hydrobromide
Synonyms: methyl-1,2,5,6-tetrahydro-1-methyl;nicotinicacid,1,2,5,6-tetrahydro-1-methyl-,methylester,hydrobromide;n-methyltetrahydronicotinicacidmethylesterhydrobromide;1-METHYL-1,2,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER HYDROBROMIDE;METHYL 1-METHYL-1,2,5,6-TETRAHYDRONICOTINATE HYDROBROMIDE;METHYL 1-METHYL-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLATE HYDROBROMIDE;METHYL 1,2,5,6-TETRAHYDRO-1-METHYL-3-PYRIDINECARBOXYLATE HYDROBROMIDE;METHYL 1,2,5,6-TETRAHYDRO-1-METHYLNICOTINATE HYDROBROMIDE
CAS: 300-08-3
MF: C8H14BrNO2
MW: 236.11
EINECS: 206-087-3
Arecoline hydrobromide Structure
 
Chemical Properties
Melting point 171-175 °C
storage temp. Refrigerator
solubility H2O: 0.1 g/mL, clear, colorless
form Powder
pka 6.84(at 25℃)
color White to light yellow
Merck 14,778
BRN 3914826
InChIKey AXOJRQLKMVSHHZ-UHFFFAOYSA-N
 
 
 
Usage And Synthesis
Description Arecoline hydrobromide is an arecoline salt of hydrobromic acid generally used in removing parasites from dog’s intestine1-2. It has been used for almost half a century for the treatment of Echinococcus granulosus in dogs, as an anthelminthic2-4. The vermifuge action of arecoline is due to a combination of factors, including (a) the increased activity of the intestinal glands, resulting in a copious secretion which may tend to loosen the hold of the worms on the mucous membrane, when (b) the increased peristalsis sweeps them onward to be voided with the faeces. It has a strong parasympathomimetic action4. It may have been used as working standard in the determination of arecoline concentration from dog plasma using LC–MS/MS1.
Appearance WHITE FINE POWDER
Uses Arecoline is a muscarinic acetylcholine receptor agonist. Arecoline induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells. In a study, a controlled trial involving 122 dogs experimentally infected with Echinococcus
Uses A cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Anthelmintic (Cestodes); cathartic.
General Description Arecoline is an alkaloid obtained from theseeds of the betel nut (Areca catechu). For many years, nativesof the East Indies have consumed the betel nut as asource of a euphoria-creating substance.
Enzyme inhibitor This CNS-active alkaloid (FW = 155.19 g/mol; CAS 63-75-2; pK ~ 6.8), a also named methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate, from the areca nut (Areca catechu), is a partial agonist of muscarinic M1, M2, M3, and M4 acetylcholine receptors, giving rise to its well-known parasympathetic effects, including pupillary and bronchial constriction (1- 3). (Note: Some muscarinic agonists also cause cause significant receptor internalization and down-regulation; others are allosteric ligands. In this respect, the action of arecoline may not be that of a classical partial agonist acting at a receptor’s primary binding site.) Arecoline induces dose- dependent antinociception (0.3-1 mg/kg, i.p.) that can be prevented by muscarinic antagonists: pirenzepine (0.1 μg/mouse, i.c.v.) or S- (–) -ET-126 (0.01 μg/mouse, i.c.v.). Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. It also excites the colonic smooth muscle motility via M3 receptors in rabbits. In some Asian countries, the areca nut is chewed along with betel leaf for its stimulating effects. This practice can have devastating long-term consequences, including aggressive oral cancer. Oral submucous fibrosis (OSF), a chronic inflammatory disease characterized by the accumulation of excess collagen, is a condition occurring often in individuals who frequently chew areca nuts. Notably, arecoline markedly induces morphologic change in HaCaT cells (transformed human epithelial cells derived from adult skin), but has no obvious effect on Hel cells (human embryo fibroblasts). Arecoline also attenuates the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) - induced CYP1A1 activation, mainly via down-regulation of AhR expression in human hepatoma cells, suggesting the possible involvement of arecoline in the AhR-mediated metabolism of environmental toxicants in liver.

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