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99.25% High Assay Pharmaceutical Anabolic Steroids Intermediate Pregnenolone

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99.25% High Assay Pharmaceutical Anabolic Steroids Intermediate Pregnenolone

99.25% High Assay Pharmaceutical Anabolic Steroids Intermediate Pregnenolone
99.25% High Assay Pharmaceutical Anabolic Steroids Intermediate Pregnenolone

Large Image :  99.25% High Assay Pharmaceutical Anabolic Steroids Intermediate Pregnenolone

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 145-13-1
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 300 KG/Month
Detailed Product Description
Product Name: Pregnenolone MF: C21H32O2
MW: 316.48 EINECS: 205-647-4
MP: 188-190 °C Storage Temp: -20°C Freezer
Appearance: White Crystalline Powder
High Light:

pharmaceutical active ingredients

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pharmaceutical anabolic steroids

 

99.25% High Assay Steroid Intermediate Pregnenolone Raw Powder

 

 

Description :

Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of

 

neurosteroids that are found in high concentrations in certain areas of the brain, and are

 

synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance

 

myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to

 

improve cognitive and memory functioning. Pregnenolone is also being considered as a potential

 

treatment for schizophrenia.

 

Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the

 

GABAA receptor as well as a positive allosteric modulator of the NMDA receptor. In addition, it

 

has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in

 

hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release.

 

Pregnenolone, a molecule produced by the brain, acts as a natural defense mechanism against

 

effects of cannabis/marijuana in animals. Pregnenolone prevents THC/Tetrahydrocannabinol, the

 

main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that

 

when overstimulated by THC/Tetrahydrocannabinol causes the intoxicating effects of

 

cannabis/marijuana.

 

 

Pregnenolone undergoes further steroid metabolism in one of three ways.

 

Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-

 

beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double

 

bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in

 

production of 17-hydroxy progesterone and andros tenedione, precursor to test osterone and

 

estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
 

 

Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase

 

(CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to

 

dehydroepiandros terone (DH EA) using a desmolase. DH EA is the precursor of andros

 

tenedione.

 

 

99.25% High Assay Pharmaceutical Anabolic Steroids Intermediate Pregnenolone 0

 

 

 
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