Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 103-90-2
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Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Paracetamol Other Name: Acetaminophen
CAS: 103-90-2 Appearance: White Powder
Usage: Pain Killer Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2

 

 

4-Acetamidophenol

 

Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2 0
 

CAS:103-90-2

MF:C8H9NO2

MW:151.16

EINECS:203-157-5

Synonyms:4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide;ParacetaMol 0;Flutter pain;Acetaminophen solution ;4-Amidino-Nα-(naphthalene-2-sulfonylglycyl)-DL-phenylalanine-piperidide acetate salt;Paracetamol for equipment qualification;4'-Hydroxyacetanilide for synthesis;4-ACETAMIDOPHENOL

 
 
Properties
 

Melting point:168-172 °C(lit.)

Density 1,293 g/cm3

Flash point:11 °C

storage temp. Store at RT

solubility ethanol: soluble0.5M, clear, colorless

form Crystals or Crystalline Powder

color White

PH5.5-6.5 (H2O, 20℃)(saturated solution)

explosive limit15%(V)

Water Solubility 14 g/L (20 ºC)

Merck 14,47

BRN 2208089

InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N

 
 
Safety Information
 

Symbol(GHS)

Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2 1Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2 2Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2 3Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2 4Antipyretic Analgesics Pharmaceutical Raw Materials Paracetamol / Acetaminophen CAS 103-90-2 5

 

 

Abstract

 

Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain. There is poor evidence for fever relief in children. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery.It is typically used either by mouth or rectally but is also available intravenously. Effects last between two and four hours.

Paracetamol is generally safe at recommended doses. Serious skin rashes may rarely occur. Too high a dose can result in liver failure. It appears to be safe during pregnancy and when breastfeeding. In those with liver disease, it may still be used, but lower doses should be taken. Paracetamol is classified as a mild analgesic. It does not have significant anti-inflammatory activity and how it works is not entirely clear.

 

 

Specification

 

Tests Standards Results
Appearance White or almost white ,crystalline powder. White,crystalline powder.
Identification A:IR absorption Complies Complies
B:UV absorption Complies Complies
C:TLC Complies Complies
Melting point 168~172C 169.0~170.9C
Water Not more than0.5% 0.08%
Related substance Impurity(chloroacetanilide)not more than 10 ppm 2ppm
   
   
any other impurity not more than 0.05% 0.01%
Total of other impurities not more than 0.1% 0.02%
Residue on ignition Not more than 0.1% 0.05%
Chloride Not more than 0.014% Less than 0.014%
Sulfate Not more than 0.02% Less than 0.02%
Sulfide Conforms Conforms
Heavy metals Not more than 0.001% Less than 0.001%
Free p-aminophenol Not more than 0.005% Less than 0.005%
Limit of Pchloroa
cetanilide
Not more than 0.001% Less than 0.001%
Readily carbonizable substances Conforms Conforms
Residual solvents Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% 0.08%
Assay(anhydrous basis) 99.0~101.0% 99.6%
Conclusion: Complies with USP34 / BP2011

 

 

Applications


1. Medical uses:
Fever
Paracetamol is used for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 °C (101.3 °F).[24] The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.

Pain
Paracetamol is used for the relief of mild to moderate pain. The use of the intravenous form for pain of sudden onset in people in the emergency department is supported by limited evidence.

Osteoarthritis
The American College of Rheumatology recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss.A 2015 review, however, found it provided only a small benefit in osteoarthritis.

Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the NSAIDs aspirin and ibuprofen, but ibuprofen and paracetamol have similar effects in the treatment of headache. Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint.It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns about bleeding with aspirin.

Low back pain
Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first-line treatment for low back pain.However, other systematic reviews concluded that evidence for its efficacy is lacking.

Headaches


Postoperative pain
Paracetamol combined with NSAIDs may be more effective for treating postoperative pain than either paracetamol alone or NSAIDs alone.

Other



2. Veterinary use:
Paracetamol has also been widely used in the veterinary area, the effect has been proved by the treatment of cats, dogs, snakes, and other animals without or with rare side effects.

How to Take Paracetamol?


How much you can take depends on your age, your weight, the type of paracetamol you're taking and how strong it is. For example:


Adults can usually take one or two 500mg tablets every 4-6 hours, but shouldn't take more than 4g (eight 500mg tablets) in the space of 24 hours.


Children under 16 need to take a lower dose, depending on their age or weight - check the packet or leaflet, or ask a pharmacist or doctor for advice. For very young children, paracetamol liquid is given using a measuring spoon or an oral syringe.


Paracetamol should start to work within an hour and the effect usually lasts several hours. Don't take more than the recommended dose if it isn't relieving your symptoms.


Adults can take ibuprofen at the same time if necessary, but this isn't usually recommended for children.

Paracetamol Storage:
A: Keep out of the reach and sight of children.
B: Store below 25° C in a dry place, protected from light.
C: Do not use Paracetamol tablets after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month.

 

 

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