Giant Steroid Pharma Co.,Ltd

Giant Steroid Pharm Co.,Ltd
Quality Product 丨 Safe Delivery 丨 Professional Service

Home ProductsPharmaceutical Raw Materials

CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor

Certification
China Giant Steroid Pharma Co.,Ltd certification
China Giant Steroid Pharma Co.,Ltd certification
I have NO interest in any other suppliers but you, Tom. I was hugely impressed with your efficiency and product quality. Thank you very much.

—— Andrew S (UK)

Tom is a man of his word, and he pulled through when nobody else could! I will not hesitate to order from him again. Top notch service and quality!

—— James K (Australia)

Package came very quickly, thanks Tom. You're definitely my new guy. You're great to deal with.

—— Haydee Rodriguez (USA)

I'm Online Chat Now

CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor

CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor
CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor

Large Image :  CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 183319-69-9
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable ( Discounts For Big Order )
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Detailed Product Description
Product Name: Erlotinib Hydrochloride Other Name: Erlotinib HCL
CAS: 183319-69-9 Appearance: White Powder
Usage: Small Molecule Tyrosine Kinase Inhibitor Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Grade Standard: Medicine Grade Purity: 99%
Shelf Life: 2 Years
High Light:

pharmaceutical active ingredients

,

pharmaceutical anabolic steroids

 

 

Erlotinib HCL

 

 

 

Product Name: Erlotinib hydrochloride
Synonyms: Erlotinib HCl (OSI-744);Erlotinib hydrochloride, 98.5%;Tarceva, CP-358774;Erlotinib Hydrochloride WS;NSC 718781) HCl;Erlotinib hydrochloride N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride;Erlotinib HCl, >=99%;CP-358774-01
CAS: 183319-69-9
MF: C22H24ClN3O4
MW: 429.9
EINECS: 620-491-0
Erlotinib hydrochloride Structure
 
Erlotinib hydrochloride Chemical Properties
Melting point 223-225°C
storage temp. -20°C Freezer
pka pKa (25°): 5.42
 
 
 
Erlotinib hydrochloride Usage And Synthesis
Indications and Usage Erlotinib hydrochlorate is a small molecule tyrosine kinase inhibitor which acts reversibly on epidermal growth factor receptors, a hydrochloride of erlotinib, a molecular-targeted drug. The US Food and Drug Administration (FDA) has approved erlotinib (Tarceva) combined with gemcitabine as a first-line treatment for locally advanced and metastatic pancreatic cancer.
It is mainly used as a second- or third-line treatment for locally advanced or metstatic non-small cell lung cancer (NSCLC) and as a treatment for pancreatic cancer. It is used as a tyrosine inhibitor for NSCLC treatment.
Mechanisms of Action The small molecular compound erlotinib is a tyrosine kinase receptor inhibitor which inhibits the proliferation of tumor cells by inhibiting phosphorylation, binding to the intracellular catalytic domain of tyrosine kinase in competition with ATP, thus blocking downstream signal transduction and inhibiting activity of tumor cell ligand dependent HER-1/EGFR.
Clinical Research Phase I clinical trials showed that the main toxicities and side effects of erlotinib were dose-dependent rashes and diarrhea. Other rare side effects included headaches, nausea, and vomiting. Phase II trials used erlotinib as a second-line anticancer drug, with efficacy matching second-line chemotherapy drug docetaxel. Phase III randomized control trials (BR21) mainly focused on NSCLC patients (locally advanced and distant metastasis) after the failure of first- or second-line chemotherapy. The treatment group, with 488 cases in total, took 150mg of erlotinib daily. The control group (243 cases) took a placebo. The study showed:
Median survival rate: 6.7 months for the treatment group, 4.7 months for the control (P<0.001, hazard ratio HR=0.73)
1 year survival rate: 31.2% for the treatment group, 21.5% for the control
Median time of no progression: 9.9 weeks for the treatment group, 7.9 weeks for the control
Meanwhile, symptomatic improvement in the treatment group was more pronounced.
Based on the results of the BR21 study, several further phase III clinical trials were conducted. The TRIBUTE trial combined erlotinib with chemotherapy. The treatment group used chemotherapy (carboplatin + paclitaxel) + erlotinib, while the control used the same chemotherapy alone, with a total of 1,059 late-stage NSCLC patients. The effectiveness of the treatment group was 21.5%, and the control group 19.3%; median survival times were 10.8 and 10.6 months, respectively, and the times of tumor progression (TTP) were 5.1 and 5.0 months. Meanwhile, TALENT trials, with 1,172 NSCLC patients, also investigated the effects of adding erlotinib to chemotherapy (gemcitabine + cisplatin), and also failed to show that erlotinib significantly increased its effects.
Chemical Properties Off-White Solid
Uses Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic
Uses Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM.
Uses Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.
Definition ChEBI: A quinazoline hydrochloride compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.
Brand name Tarceva (OSI).
General Description Erlotinib is available as 25-, 100-, and 150-mg tablets fororal administration and is used after failure of first-linetherapy in metastatic NSCLC and as first-line therapy incombination with gemcitabine in the treatment of metastaticpancreatic cancer, and in treating malignant gliomas.The structural similarity to gefitnib imparts similar pharmacokineticbehavior with bioavailability of 60% and proteinbinding of 93%. The agent is extensively metabolizedprimarily by CYP3A4. Three major metabolic pathwayshave been identified, involving oxidative-O-demethylationof the side chains followed by further oxidation to give thecarboxlic acids, oxidation of the acetylene functionalityto give a carboxylic acid, and aromatic hydroxylation ofthe phenyl ring para to the electron-donating nitrogen. Themetabolites are primarily eliminated in the feces, and theterminal half-life is 36 hours.The major toxicities seenwith the agent are dose-limiting skin rash and diarrhea.Other common adverse effects include shortness of breath,fatigue, and nausea.

 

 

CAS 183319-69-9 Erlotinib Hydrochloride / Erlotinib HCL 99% Whie Powder Small molecule tyrosine kinase inhibitor 1

 

 

Hot Selling Steroid Powder

 
Oral Products Oxandrolone (Anavar) Stanozolol (Winstrol)
Oxymetholone (Anadrol) Dianabol(Methandrostenolone)
Testosterone Test Base 17-methyltestostero(methyl testos terone)
Test Enanthate 17α-Methyl-Testos terone
Test Acetate Oral turinabol(4-Chlorodehydromethyltestosterone)
Test Propionate
(Test Phenylpropionate)
Turinabol(Chloroterone Acetate,Clostebol Acetate)
Test Isocaproate Hexadrone
Test Decanoate Mesterolone(Proviron)
Test Undecanoate Test Cypionate
1-Testosterone Test Sustanon 250
1-Testosterone Cypionate  
Nandrolone Nandrolone Nandrolone Undecanoate
Nandrolone Propionate Nandrolone Cypiontate
Nandrolone Decanoate(DECA) Stanolone (DHT)
Nandrolone Phenypropionate  
Mestanolone  
Boldenone Boldenone base  
Boldenone Propionate  
Boldenone Undecylenate(Equipoise)  
Boldenone cypiontate  
Boldenone Acetate  
Trenbolone Trenbolone base  
Trenbolone acetate (Finaplix)  
Trenbolone enanthate (Parabolan)  
Trenbolone hexahydrobenzyl Carbonate  
Ti bolone  
Methylstenbolone  
Methenolone Drostanolone Propionate (Masteron p)  
Methenolone Enanthate Methenolone Acetate
DH EA DHEA(Dehydroepiandrosterone) Epiandrosterone
1-DHEA Epiandrosterone Acetate
4-DHEA  
7-Keto-DH EA  
   
Others Methyl dienedione 2, 4-Dinitrophenol
Trendione/Trenavar Dustasteride
6-OXO Des onide
11-OXO Tria mcinolone
Epistane/Methyl Epitiostanol Finasteride
Androstatrienedione Cytomel, T3
  L-Thyroxine, T4
  Rimonabant
  L-Carnitine
Sex Enhancer Flibanserin Acetildenafil (Hongdenafil)
Cia lis (Tadalafil) Yohimbine Hcl
Via gra (Silde nafil) Vardenafil (Le vitra)  
  Maca Extract
Pain Killer Benzocaine / Benzocaine hcl Tetracaine / Tetracaine HCL
Procaine / Procaine Hcl Bupivacaine/ Bupivacaine HCL
Lidocaine HCL Articaine / Articaine hcl
Anti-Estrogen Tamoxifen Citrate (Nolvadex) Anastrozole (Arimidex)
Clomiphene citrate (Clomid) Letrazole(Femara / For mestane)
Exe mestane(Aromasin)  
Pharmaceuticals Phe nacetin Raloxifene HCL
  Theophylline
Dexamethasone Sodium Phosphate Fura zabol THP
Paracetamol Atorvastatin Calcium
Pregabalin Lorcaserin
  Carbergoline
Safe Organic Solvents Gamma-Butyrolactones(GBLsolvents ) Benzyl Alcohol(BA)
1,4-Butanediol(BDO) Benzyl benzoate(BB)
Ethyl Oleate(EO) Guaiacol
Grape Seed Oil(GSO) Poly Ethylene Glycol(PEG)
  Polysorbate 80
H G H&Peptides HGH 176-191 2mg/vial Ipamorelin 2mg/vial
MGF PEG MGF Hexarelin 2mg/vial
CJC-1295 / with DAC Sermorelin 2mg/vial
PT-141 10mg/vial Selank 5mg/vial
MT-1 MT-2 10mg/vial Follistatin 344
GHRP-2 5mg/vial & 10mg/vial Follistatin 315
GHRP-6 5mg/vial & 10mg/vial Eptifibatide
SARMs Aicar MK-2866/Ostarine/Enobosarm
Andarine / S4 RAD-140
Andarine / GTX-007 SR9011
GW-501516(cardarine) SR9009
LGD-4033 Sunifiram
MK-677/Ibutamoren/Nutrobal YK11

Contact Details
Giant Steroid Pharma Co.,Ltd

Contact Person: sales

Tel: +8615827096298

Send your inquiry directly to us (0 / 3000)