|Place of Origin:||CHINA|
|Certification:||GMP , ISO 9001:2008|
|Minimum Order Quantity:||10vials|
|Packaging Details:||Stealth And Discreet Packaging|
|Delivery Time:||Within 7 Working Days|
|Payment Terms:||Bank Transfer - Bitcoin - Western Union - MoneyGram|
|Supply Ability:||1000kg per month|
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|Purity (HPLC):||98% Min|
|Appearance :||White powder|
SNAP-8 has been shown in research studies to be non-pharmaceutical topical alternative to Botox (Botulism Toxin). Research studies have shown that SNAP-8 is a safer, cheaper, and milder alternative to Botox (Botulisum Toxin). A topical alternative to Botox (Botulisum Toxin) targeting the same wrinkle-formation mechanism in a very different and much safer way.
The anti wrinkle octapeptide SNAP-8 is an elongation of the famous hexapeptide Argireline. SNAP-8 reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles. Like Argireline, inhibits SNARE complex formation and catecholamine release, resulting in the reduction of the degree of existing facial wrinkles and demonstrated effectiveness against their development with regular use. In clinical studies, the severity of wrinkles around the eyes decreased up to 63.13%. Both in vivo and in vitro efficacy testing suggests that SNAP-8 is approximately 30% more active than its parent peptide Argireline. As supplied by the manufacturer, this product contains 0.05% SNAP-8 powder aka Acetyl Octapeptide-3.
SNAP-8 is a safer, cheaper, and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way. SNAP-8 can be incorporated in cosmetic formulations such as emulsions, gels, and serums where attenuation of the deep lines or wrinkles in the forehead or around the eye are is desired.
SNAP-8 can be incorporated at the final stage of the manufacturing process, provided the temperature is below 40°C (104°F). For storage it is recommended to store at 4°C (39°F). In rare cases, refrigerated storage of SNAP-8 Solution can cause precipitation of the preservative. This does not affect the integrity of the product.
Note, the correct INCI name for SNAP-8 aka Acetyl Glutamyl Heptapeptide-1 is Acetyl Octapeptide-3.
SNAP-8 peptide’s scientific name is Acetyle Glutamyl Heptapeptide-1. It is being tested
for use for anti-wrinkle solutions. Studies show that SNAP 8 has properties that enable it
to reduce the depth of wrinkles that are caused by everyday muscle contractions. In animal
test subjects, it has shown significant results around the eyes and forehead. This product
is considered to be a milder, more cost-effective and safer alternative to Botulinum Toxin.
SNAP 8 works similarly to Botulinum Toxin by targeting the same wrinkle formations, but in
a unique way.
Test Results of SNAP 8 Peptide:
VIVO testing was performed to determine how effective small peptides are with providing
stability for the SNARE complex. This allowed the researchers to follow the thermal
stability and formation of the reconstituted SNARE protein complex. This basically
evaluates the effectiveness of the peptides that are patterned like SNAP-25 N and its
ability to amass with synaptobrein and syntaxin that is being formed with the SNARE
complex. The final result was that the short peptides that came from the N-terminal end of
SNP-25 were able to compete with the natural protein and stop it from forming SNARE complex by changing the stability.
Another test was done with test subjects. The cream used consisted of 10 percent SNAP 8.
Researchers obtained silicon imprints from around the eyes of 17 test subjects. These
silicon imprints were taken before the test began. The test subjects applied the cream
twice daily, and then another sample was taken 28 days later. The imprints were analyzed
using control laser scanning microscopy to see the difference between the skin surface of
the sample taken before and after treatment. In order to see a three dimensional view of
the samples, skin topography images were created. Within these images, it was observed that
the depth of the wrinkles had decreased significantly after receiving treatment for 28
days. The max reduction that was seen with the 10 percent SNAP 8 solution was 63.18
How Does SNAP 8 Peptides Work ?
SNAP 8 is a copy of the N-terminal end of SNAP-25. This competes with SNAP-25 to position
itself within the SNARE complex, which then modulates its creation. When the SNARE complex is destabilized slightly, it is impossible for the vesicle to release neurotransmitters in
an efficient manner. Because of this, muscle contractions are reduced, so that wrinkles and
lines are prevented. It will also help reduce existing fine lines and wrinkles by
inhibiting the formation of SNARE complex and the release of catecholamine. With regular
use in test subjects, it also prevented the development of wrinkles and lines.
Clinical studies show that SNAP 8 helped to reduce wrinkles surrounding the eyes by up to
63.13 percent. Testing for vitro and vivo efficiency showed that SNAP 8 has 30 percent more
activity than parent peptides like Argireline.
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