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GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass

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GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass

GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass
GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass

Large Image :  GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 901758-09-6
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Detailed Product Description
Product Name: GDF-8 Specification: 1 Mg/vial
CAS: 901758-09-6 Appearance: White Powder
Usage: Bodybuilding Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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muscle building supplements

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growth hormone peptides

 

  GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass

 

 

Abstract

 

1. Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

2. Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

 

GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass 0

 

 

Application

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.


Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

 

 

COA

 

Item Specification Result
Appearance White powder Complies
Identification Positive Complies
Assay 99.0% min 99. 3%
Loss on Drying 6.0%max. 4.80%
Mass Balance 95.0~105.0% Complies
Acetate Content (HPIC) 12.0%max. 10.80%
Peptide Content (N%) 80.0%min. 88.00%
Amino Acid Composition ±10% of theoretical Complies
Single Impurity (HPLC) 1.0%max. 0.85%

 

 

Structure and mechanism of action


Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.


Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition. Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

 

GDF-8 Muscle Building Peptides Myostatin 1 mg/vial CAS 901758-09-6 For Muscle Mass 1

 

 

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.

2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.

3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.

b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.

4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

 

 

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Our Advantage

1.Good quality.All products are produced under GMP conditions according to Standard Operation 1.Procedure(SOP), not from little underground labs or black markets, so the quality is guaranteed.

2.Discreet packing methods.For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels.

3.99.99% customs clearance rate. We have rich experience in shipping parcel to USA, Australia, UK, Canada, Brazil, Russia, Germany, Poland, Mexico, etc.

4. Injectable steroid. We offer melting powder into liquid service. And ship the liquid in special bottles .1. Good quality.All products are produced under GMP conditions according to Standard Operation Procedure(SOP), not from little underground labs or black markets, so the quality is guaranteed.

5. Discreet packing methods. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels.

6. Injectable steroid. We offer melting powder into liquid service. And ship the liquid in special bottles.

 

 

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