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High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia

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High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia

High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia
High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia

Large Image :  High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 120014-06-4
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Work Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Detailed Product Description
Product Name: Donepezil Other Name: 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Appearance: White Powder Assay: 99%
Usage: Antidepressant Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia

 

 

2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia 0
 

CAS:120014-06-4

MF: C24H29NO3

MW: 379.49

Synonyms: DONEPEZIL;2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;AKOS 226-23;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde ;n-1-one ;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one

 

Properties

Melting point: 207°C

Water Solubility 2.931 mg/L

 

 

Abstract

 

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

 

 

Specification

 

TEST ITEM SPECIFICATION RESULT
Appearance Off white to white crystalline powder Complies
Solubility freely Freely soluble in chloroform, soluble
in water and Acetic acid, slightly soluble in
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane
Complies
Identification (1)By IR absorption ,To match with working
standard
Complies
(2) The retention time of the major peak of
the sample should accord with that of the
working standard.
Complies
(3) Test for chlorides. Reponds to the test
for Chlorides.
Complies
PH 4.0-7.0 6.10
Residue on ignition ≤0.1% 0.03%
Related substance Any Unkonwn single impurity≤0.3%
Total ≤0.5%
0.04%
0.18%
Heavy metal ≤10ppm <10ppm
Residual Solvents Methanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5%
Not detected
Not detected
Not detected
Not detected
Not detected
Loss on drying ≤0.5% 0.20%
Assay On dried base, C24H29NO3·HCl
should be 98.0% to 102.0%
100.20%
Conclusion: The product complies to Enterprise standard

 

 

Application

Donepezil is used to treat confusion (dementia) related to Alzheimer's disease. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to function. This medication is an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain.

 

High Quality Pharmaceutical Raw Materials Smart Drug Donepezil CAS 120014-06-4 For Confusion Dementia 1

 

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