Pentadecapeptide BPC 157 CAS 137525-51-0 Human Growth Polypeptide Hormones Supplements Peptide Drum

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 137525-51-0
Minimum Order Quantity: 10 vials
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Supply Ability: 2000KG/Month
CAS: 137525-51-0 Alias: Pentadecapeptide BPC 157 ; Booly Protection Compound 15
MF: C62H98N16O22 MW: 1419.53552
Method Of Analysis: HPLC Appearance: White Lyophilized Powder
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Product Name: BPC 157

Product details:

 

Product name BPC-157
Specification 2mg/vial
Appearance Lyophilized White Powder
CAS NO. 137525-51-0
Synonyms Pentadecapeptide,Bpc 15, Bpc-157, Booly protection compound 15
Molecular Weight 1419.53552
Molecular Formula C62H98N16O22

Sequence
Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Method of Analysis HPLC
Storage

Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°CBPC 157 is stable at room temperature for 90 days, It should be stored in a freezer for any extended period of time.

 

Reports »Certificate of Analysis
»HPLC Report
»Mass Spectrum

Terms
The products we offer are intended for laboratory research use only. Please familiarize yourself with our Terms and conditions prior to ordering.

 

Description:

 

BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice. Experiments have shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats. The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an injured tendon. The study used two group of tendon explants of which one group was cultured in a BPC 157 - containing medium while the other group was cultured in a medium lacking BPC 157.


Additionally, FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.


Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-saystem, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis.

 

Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, M.W. 1419, PL 14736) and wound healing, stable in human gastric juice and has no reported toxicity. We focused on BPC 157 as a therapy in peridontitis, esophagus, stomach, duodenum, intestine, liver and pancreas lesions. Particularly, it has a prominent effect on alcohol-lesions (i.e., acute, chronic) and NSAIDs-lesions (interestingly, BPC 157 both prevents and reverses adjuvant arthritis). In rat esophagitis and failed function of both lower esophageal sphincter (LES) and pyloric sphincters (PS), BPC 157 increased pressure in both sphincters till normal and reduced esophagitis.
However, in healthy rats, it may decrease (PS) or increase (LES) the pressure in sphincters. It has strong angiogenic potential, it acts protectively on endothelium, prevents and reverses thrombus formation after abdominal aorta anastomosis, affects many central disturbances (i.e., dopamine and 5-HT system), the NO-system (either L-arginine and L-NAME effects), endothelin, acts as a free radical scavenger (counteracting CCl4-, paracetamol-, diclofenac-injuries) and exhibits neuroprotective properties.

 

 

Applications:

 

1). BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models.
2). BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.
3). BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.
BPC 157 significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.

 

 

BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models,it may become an important therapeutic tool for the treatment of inflammatory bowel disease.BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.And it significantly facilitates the healing of bone fracture in rats,exhibits an osteogenic effect significantly improving the healing of segmental bone defect.BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle,significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.

 

BPC 157 successfully heals the intestinal anastomosis, gastrocutaneous, duodenocutaneous and colocutaneous fistulas in rats, as well as interacting with the NO system. Interestingly, the fistula closure was achieved even when the BPC 157 therapy was postponed for one month. In short-bowel syndrome escalating throughout 4 weeks the constant weight gain above preoperative values started immediately with BPC 157 therapy, peroral and parenteral, and the villus height, crypt depth and muscle thickness additionally increased. Thus, BPC 157 may improve gastrointestinal tract therapy.


BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker, L-NAME (prothrombotic) and the NOS-substrate L-arginine (antithrombotic), were little investigated. Objective. To investigate the effect of L-NAME and L-arginine on hemostatic parameters, and to reveal the effects of BPC 157 on the L-NAME- and L-arginine-induced hemostatic actions under different pathological condition: tail amputation without or with anticoagulants, heparin or warfarin.


BPC 157 was proven to speed-heal tears in quadriceps muscles, as it also promoted faster healing of Achilles tendons, damaged muscle tissue and crushed muscle tissue. It also helped with recovery from torn muscles.


This peptide is also believed to decrease pain in damaged areas. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide, once it is approved for usage in human subjects.

 

Pentadecapeptide BPC 157 CAS 137525-51-0 Human Growth Polypeptide Hormones Supplements Peptide Drum 0

 

 

Used In Humans:


well BPC 157 is known for super quick and professional Joint/tendon/ligament healing in all phases of clinical trials. Studies are shown here: BPC 157 has been shown in studies to heal torn quadriceps muscles, detached achilles tendon, muscles that have been damaged/crushed. Demonstrating dramatic fast recovery from muscle tears. Tendon to bone healing - increased ligament healing, BPC 157 has a variety of protective effects in the organs. Clinical trials demonstrate healing and prevention of stomach ulcers and it is being studied as a burn treatment. Trials show it may help repair some liver damage after prolonged chronic alcohol exposure. No adverse reactions have been seen in clinical trials.
BPC 157 peptide has been shown to heal a variety of wounds in all areas researched, including internal organs, muscles, ligaments, tendons, skin, internal lacerations from surgery. It can have a use in the medical industry help heal and get rid of stomach ulcers caused by people abusing NSAID drugs.

 

 

 

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