Pharmaceutical Raw Material White Powder Memantine HCl CAS 41100-52-1 With Factory Price And Fast Delivery

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 41100-52-1
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Work Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Memantine HCl CAS: 41100-52-1
Appearance: White Powder Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
MF: C12H22ClN MW: 215.76
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Pharmaceutical Raw Material White Powder Memantine HCl CAS 41100-52-1 With Factory Price And Fast Delivery

 

 

Memantine HCl

 

Pharmaceutical Raw Material White Powder Memantine HCl CAS 41100-52-1 With Factory Price And Fast Delivery 0
 

CAS:41100-52-1

MF:C12H22ClN

MW:215.76

EINECS:255-219-6

Synonyms:MEMANTINE HCL;LABOTEST-BB LT00233220;D-145;1,3-Dimethyl-5-aminoadamantane hydrochloride;1,3-DIMETHYLAMINOADAMANTANE HYDROCHLORIDE;1-AMINO-3,5-DIMETHYLADAMANTANE HCL;1-AMINO-3,5-DIMETHYLADAMANTANE HYDROCHLORIDE;1-AMINO-3,4-DIMETHYLADAMANTANE HYDROCHLORIDE

 
 

Properties

 

Melting point:292 °C

storage temp. -20°C Freezer

form Fine Powder

color White

Merck 5806

 
 
Safety Information
 

Symbol(GHS)

Pharmaceutical Raw Material White Powder Memantine HCl CAS 41100-52-1 With Factory Price And Fast Delivery 1

 

 

Abstract

 

Overview of memantine hydrochloride is dementia drugs developed by the German company Merz, is a new type of low, moderate affinity, voltage dependent and non competitive N methyl D aspartate (NMDA) receptor antagonist can noncompetitive NMDA receptor blockade induced by glutamate receptor NMDA, reduce the excessive excitement, prevent cell apoptosis, improve memory, is a new generation of drugs to improve cognitive function.


In February 2002, the European Commission (CPMP) approved the drug patent for moderate to severe Alzheimer's disease treatment, in August of the same year in the German market, in October 17, 2003 by the U.S. Food and Drug Administration (FDA) approved for the treatment of moderate to severe Alzheimer's disease patients. Further studies show that memantine hydrochloride is effective for mild to moderate Alzheimer's disease.

 

Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European. The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity. Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs). Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other.



what is Alzheimer's disease?

Alzheimer's disease (Alzheimer, disease, AD), also known as Alzheimer's disease, is one of the common diseases of the elderly, mainly for the loss of memory and ability to identify barriers, is a progressive neurological degenerative disease. At present, cholinesterase inhibitors (donepezil, galantamine, Kabbala ting) and memantine hydrochloride is approved for the treatment of Blzheimer's disease.


Characters of memantine hydrochloride is white crystal or powder. Molecular weight: 215.81.
Pharmacokinetics of oral administration of memantine hydrochloride has good absorption, and no food, treatment dose range, the linear dynamic feature of medicine, age and gender does not affect its pharmacokinetics. Oral administration of 3 ~ 7h peak blood concentration of t1/2 is 60 ~ 80h, the average volume of distribution of 9 ~ 11L / kg -1, the 45% rate of plasma protein binding, 57% ~ 82% to the rest of the prototype, metabolite of N -3, 5- two - methyl glucuronide, 6- hydroxy memantine and 1- nitroso - deamination dollars just by the form of urine excretion. Metabolites have a certain NMDA receptor antagonist activity. Renal clearance was affected by urine pH, urine pH value was 8, renal clearance decreased by 80%.

 

Pharmaceutical Raw Material White Powder Memantine HCl CAS 41100-52-1 With Factory Price And Fast Delivery 2

 

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