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Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

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Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For  Anti Estrogen
Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For  Anti Estrogen Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For  Anti Estrogen

Large Image :  Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 82640-04-8
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Work Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Detailed Product Description
Product Name: Raloxifene Hydrochloride CAS: 82640-04-8
Appearance: White Powder Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
MF: C28H28ClNO4S MW: 510.04
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Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

 

 

Raloxifene Hydrochloride

Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For  Anti Estrogen 0
 

CAS:82640-04-8

MF:C28H28ClNO4S

MW:510.04

Synonyms:RALOXIFENE HCL;RALOXIFENE HYDROCHLORIDE;ly156758 ;methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin ;KEOXIFENE;KEOXIFENE HYDROCHLORIDE;LY 139481;AKOS 92138

 
 

Properties

 

Melting point:250-253°C

storage temp. -20°C Freezer

solubility DMSO: 28 mg/mL, soluble

 

 

Abstract

 

Raloxifene hydrochloride is a second-generation Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This drug is similar in effect to tamoxifen, exhibiting estrogen receptor antagonist (blocking) properties in some tissues while acting as an estrogen receptor agonist (activator) in others.

The main point of variation between these two agents is their tissue selectivity. While raloxifene hydrochloride is a strong anti-estrogen in breast and uterine tissues, it appears to be estrogenic in bone. This allows it to protect bone density, mimicking the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, which is anti-estrogenic in both breast and bone.

In a role that was novel for an anti-estrogen, raloxifene hydrochloride was approved by the FDA for the prevention and treatment of osteoporosis in post-menopausal women. It is also being investigated for several other potential uses, including the treatment and prevention of cardiovascular disease, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine cancer.


Raloxifene Hydrochloride is used to help prevent and treat thinning of the bones (osteoporosis) only in postmenopausal women.

It works like an estrogen to stop the bone loss that can develop in women after menopause, but it does not increase the bone density as much as daily 0.625 mg doses of conjugated estrogens. Raloxifene Hydrochloride will not treat hot flashes of menopause and may cause hot flashes to occur. Also, Raloxifene Hydrochloride does not stimulate the breast or uterus as estrogen does.

Raloxifene Hydrochloride lowers the blood concentrations of total and low-density lipoprotein (LDL) cholesterol, the bad cholesterols, but it does not increase concentrations of high-density lipoprotein (HDL) cholesterol, the good cholesterol, in your blood.

Raloxifene Hydrochloride is also used to lower chances of having invasive breast cancer in postmenopausal women with osteoporosis or at high risk of having invasive breast cancer .
This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Raloxifene Hydrochloride is used in certain patients with the following medical conditions:

Breast cancer prevention in high-risk women who have already gone through menopause.

 


Application


May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents or in whom such therapies are contraindicated.


Reduction in the incidence of invasive breast cancer inpostmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial).


Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established. Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer. 1 Not indicated for reduction in the risk of noninvasive breast cancer.

 

 

Usage


1. Amino acid, nutrient


2. Labeled , intended for use as an internal standard for the quantification by GC- or LC-mass
spectrometry.


3. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.


 

Mechanism of Action


Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors.

This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.

 

 

Advantage


1. Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

2. Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

3. Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 3.5kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

4. Good after-sales service.

 

 

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