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Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs

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Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs

Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs
Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs

Large Image :  Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 148553-50-8
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Detailed Product Description
Product Name: Pregabalin Other Name: Pregablin
MF: C8H17NO2 MW: 159.23
EINECS: 200-659-6 Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs

 

Pregabalin

Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 0

CAS: 148553-50-8

MF: C8H17NO2

MW:159.23

EINECS: 200-659-6

Synonyms: 3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;(3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;PREGABALIN;Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid;PREDNISOLONESODIUMPHOSPHATE;(R)-Pregabalin;(S)-Pregabalin

 

Properties

Melting point: 194-196°C

Flash point: 9℃

storage temp. Store at RT

solubility deionized water: ≥10mg/mL

 

Safety Information

Symbol(GHS)

Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 1Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 2Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 3Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 4

 

Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 5

 

 

Abstract

 

Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is a long-term condition where anxiety is a major symptom.


Pregabalin, also known as β-isobutyl-γ-Aminobutyric acid (β-isobutyl-GABA) and sold under the trade name Lyrica among others, is a medication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.

Pregabalin is a structural analogue of the neurotransmitter GABA, consequently it belongs to the γ-Aminobutyric acid analogue class of antiepileptic drugs. Its a ion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is a potent gabapentinoid and close analogue of GABOB (β-hydroxy-GABA), baclofen (β-(4-chlorophenyl)-GABA), and phenibut (β-phenyl-GABA).

 

 

COA

 



ITEMS

STANDARDS

RESULTS

Appearance

A white to off white powder

White powder

Identification

A. Meets the requirement

Complies

B. IR: similar to Reference Substance

Complies

Loss on drying

≤0.5%

0.21%

Specific Rotation

+10.0°~+13.0°

+10.8°

Related Substances

Any single impurity ≤0.1%
Total impurity ≤0.8%

0.05%
0.10%

Purity By HPLC R-isomer

≤0.15%

0.10

Residue on ignition

≤0.1%

0.05%

Residual solvents

Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm

150ppm
250ppm

Heavy metals

≤10ppm

Complies

Chlorides

≤0.05%

Complies

Assay

98%~102.0%

99.8%

Conclusion

Analyse according to Factory Standard , Conform

 

 

 

Pregabalin is indicated for

1.Treatment of neuropathic pain from diabetic neuropathy or post herpetic neuralgia. There is not enough data to state that it should be used in all neuropathic pain.


2. Adjunctive therapy in adults with partial seizures with or without secondary generalization


3. Fibromyalgia


4. Generalized anxiety disorder


5. Alcohol Withdrawal


Usually physicians will start the patient on a low dose of pregabalin and increase it gradually, depending on the patient's evaluation. Its therapeutic effect appears after 1 week of use and is similar in effectiveness to lorazepam, alprazolam and venlafaxine but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

 

Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs 6

 

 

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