Giant Steroid Pharma Co.,Ltd

Giant Steroid Pharm Co.,Ltd
Quality Product 丨 Safe Delivery 丨 Professional Service

Home ProductsPharmaceutical Raw Materials

Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

Certification
China Giant Steroid Pharma Co.,Ltd certification
China Giant Steroid Pharma Co.,Ltd certification
I have NO interest in any other suppliers but you, Tom. I was hugely impressed with your efficiency and product quality. Thank you very much.

—— Andrew S (UK)

Tom is a man of his word, and he pulled through when nobody else could! I will not hesitate to order from him again. Top notch service and quality!

—— James K (Australia)

Package came very quickly, thanks Tom. You're definitely my new guy. You're great to deal with.

—— Haydee Rodriguez (USA)

I'm Online Chat Now

Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone
Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

Large Image :  Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 50-27-1
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Detailed Product Description
Product Name: Estriol Appearance: White Powder
CAS: 50-27-1 MF: C18H24O3
MW: 288.38 EINECS: 200-022-2
High Light:

pharmaceutical active ingredients

,

pharmaceutical fine chemicals

 

 

Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

 

 

Abstract

 

Estriol belongs to natural hormone and is the metabolite of estradiol in vivo , anti estrogen steroids . It is mainly presented in the urine . Estrogen has a relative small activity with the oral activity being 6 times as high as estrone but being weaker than estradiol with non-carcinogenic effects . After its administration , the in vivo estradiol levels did not change . Estriol has selective action on the vaginal and cervical canal but has no effect on the uterus and endometrium entity .

 

Estriol,Animal experiments have shown that estriol has a stronger effect on vaginal epithelial keratosis than estradiol , thus being able to promote vaginal epithelial hyperplasia , superficial cells keratosis , mucosal angiogenesis and vaginal epithelial wound healing , but having a weak effect on the weight gain of mouse uterus At the same time , estriol can enhance the function of cervix cell , causing the cervix muscle fiber hyperplasia and increasing the cervical elasticity and softness .

 

In addition , estriol has feedback inhibition on the hypothalamus and pituitary but does not inhibit ovulation while only having significant impact on the corpus luteum and therefore can be used as the auxiliary drug in the medium-term labor induction and artificial abortion and for the treatment of various kinds of menopathy . Estriol also has significant effect on the hematopoietic system and can reduce vascular permeability and fragility. Therefore , it can be used for the treatment of various kinds of hemorrhage . It also has effect of rapidly increasing the peripheral leukocytes and generally begins to take effect at 1 to 3 days after treatment but with a shorter duration of action and is effective in treatment the leukopenia induced by radiotherapy and chemotherapy .

 

 

Basic Info.

 

Name Estriol
CAS 50-27-1
Formula C18H24O3
Molecular Weight 288.39
EINECS 200-022-2
Density 1.255 g/cm3
Melting Point 280-282 °C(lit.)
Boiling Point 469 °C at 760 mmHg
Flash Point 220.8 °C
Appearance White crystalline powder
Assay 99%
Package as per request
Storage as per relevent regulations
Application pharmaceutical intermediates
 

 

 

Application

 

Indications It can be used for treating cervicitis, especially suitable for treating menopausal syndrome and senile vaginitis. It can also be used as the adjuvant drug for middle-term labor induction and artificial abortion. It can also be used for treating prostatic hypertrophy and prostate cancer. In addition, it still has a rapid role in increasing the peripheral leukocytes. It generally takes effect at 1 to 3 days after the treatment but with a short duration period. It also has efficacy in treating leukopenia caused by chemotherapy or radiotherapy as well as reducing the vascular permeability and fragility and can be used for the treatment of various kinds of hemorrhage. It also has quick hemostasis effect on menorrhagia, hysterectomy or tonsillectomy.

 

 

Biological Activity

 

Description Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
In vitro MTT assays using G-1 shows that, in SkBr3 cells, the proliferative effect induced by 100 nM G-1 is abolished in the presence of 1 μM estriol which acts as an antagonist of GPR30-dependent pathway. A cell-free transcription assay demonstrates that the antiestrogenic activity exhibited by estriol is because of interferring with estradiol-induced positive cooperative binding and receptor dimerization, binding of hER complexes to ERE, as well as reducing estradiol-dependent transcription in a dose-dependent manner. A recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity.
In vivo In mPTEN+/- mice, estriol treatments resulted in a 187.54% gain in the relative ratio of uterine wet weight to body weight; estriol also increases the ratio to 176.88% in wild-type mice. Estriol treatment (20 mg/kg ip), in vivo, sensitizes Kupffer cells to LPS via mechanisms dependent on an increase in CD14 by elevated portal blood endotoxin caused by increased gut permeability in rats; while one-half of the rats given estriol intraperitoneally 24 hours before an injection of a sublethal dose of LPS (5 mg/kg) died within 24 hours.
 

 

Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone 0

 

Purpose and Function

 

1. It can be used for treating cervicitis and especially suitable for treating menopausal syndrome and senile vaginitis.


2. It can also be used as the adjuvant drug for middle-term labor induction and artificial abortion.

 

3. It can also be used for treating prostatic hypertrophy and prostate cancer.


4. It still has a rapid role in increasing the peripheral leukocytes. It generally takes effect at 1 to 3 days after the treatment but with a short duration period. It also has efficacy in treating leukopenia caused by chemotherapy or radiotherapy.


5. It can be used for reducing the vascular permeability and fragility and can be used for the treatment of various kinds of hemorrhage. It also has quick hemostasis effect on menorrhagia, hysterectomy or tonsillectomy.


Chemical Properties It is white crystalline powder with the M.p. being 283 ºC, relative density being 1.27, and the specific rotation being [α] 25D + 34.4°(pyridine) and 25D + 58°± 5°(4%, dioxane). Its ethanol solution has maximum absorption at the wavelength of 280 nm. The crystal is insoluble in water, slightly soluble in ethanol (1: 500), diethyl ether, chloroform, dioxane and vegetable oil and easily soluble in pyridine and alkali hydroxide solution.
 

 

Hot-Sale Products

 

Testosterone Acetate Trenbolone Acetate MGF
Testosterone Cypionate Trenbolone Enanthate PEG MGF
Testosterone Decanoate Boldenone Acetate CJC-1295
Testosterone Enanthate Boldenone undecylenate CJC-1295 DAC
Testosterone Isocaproate Boldenone Cypionate PT-141
Testosterone Phenylpropionate Boldenone Propionate Melanotan-1
Testosterone Propionate Nandrolone Decanoate Melanotan-2
Testosterone Undecanoate Nandrolone phenylpropionate GHRP-2
Mesterone Nandrolone undecylate GHRP-6
Testosterone Sustanon 250 Nandrolone cypionate Ipamorelin
Clostebol Acetate Nandrolone propionate Hexarelin
Methylandrostanolone Methyltrienolone Sermorelin
Methenolone Enanthate Drostanolone Propionate Oxytocin
Methenolone Acetate Drostanolone Enanthate TB500
Anadrol Stanolone GH 176-191
Anavar Tadalafil Triptorelin
Winstrol Vardenafil Tesamorelin
Clomifene citrate Dianabol Gonadorelin
Toremifene citrate Tamoxifen Citrate DSIP
Finasteride hydrochloride Selank

 

 

Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone 1

Contact Details
Giant Steroid Pharma Co.,Ltd

Contact Person: sales

Tel: +8615827096298

Send your inquiry directly to us (0 / 3000)