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Pirfenidone Pharmaceutical Raw Materials , Anti Inflammatory Powder Supplements

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Pirfenidone Pharmaceutical Raw Materials , Anti Inflammatory Powder Supplements

Pirfenidone Pharmaceutical Raw Materials , Anti Inflammatory Powder Supplements
Pirfenidone Pharmaceutical Raw Materials , Anti Inflammatory Powder Supplements

Large Image :  Pirfenidone Pharmaceutical Raw Materials , Anti Inflammatory Powder Supplements

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 53179-13-8
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 600 KG/Month
Detailed Product Description
Product Name: Pirfenidone Other Name: Amr-69
MF: C12H11NO MW: 185.22
MP: 96-97°C Solubility DMSO: ≥10 Mg/mL, Soluble
Appearance: Off-White Solid
High Light:

pharmaceutical active ingredients

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pharmaceutical fine chemicals

 

Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone Powder 

 

 

Description:

 

Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down

 

regulate production of multiple cytokines and block fibroblast proliferation and stimulation in

 

response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions,

 

including those of the lung, kidney and liver. It is being investigated by InterMune.

 

 

Introduction:
 

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation.

 

Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of

 

PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone,

 

taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by

 

bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can

 

also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the

 

matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA

 

synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also.

 

Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I

 

mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and

 

lung preserved ammonia acyl hydroxylase activity.

 

 

Application:
 

pirfenidone is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic

 

agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and

 

fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent

 

scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen

 

production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties

 

in variety of animal models of pulmonary fibrosis, and in clinical trials.

 

 

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