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Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease

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Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease

Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease
Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease

Large Image :  Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease

Product Details:
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 129101-54-8
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Work Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Detailed Product Description
Product Name: Rivastigmine Tartrate Usage: Alzheimer Disease
Appearance: White Powder CAS No.: 129101-54-8
Purity: 99% Min Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease

 

 

Rivastigmine Tartrate

 

Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease 0
 

CAS: 129101-54-8

MF: C18H28N2O8

MW: 400.42

Synonyms: 3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-methylcarbamate L-Tartrate N-Ethyl-N-methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate;(S)-3-(1-(diMethylaMino)ethyl)phenyl ethyl(Methyl)carbaMate (2R,3R)-2,3-dihydroxysuccinate;RivastigMine-d6 Hydrogen Tartrate;N-ethyl-N-methyl-carbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, (2R,3R)-2,3-dihydroxybutanedioate (1:1);Rivastigmine tartrate (S)-N-Ethyl-3-[(1-dimethylamino)ethyl]-N-methylphenylcarbamate hydrogen tartrate;N-Ethyl-N-methyl-carbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester tartrate;Rivastigmine for system suitability;S-Rivastigmine tartrate

 
 
Properties
 

Melting point:123-1250C

alpha D20 +4.7° (c = 5 in ethanol)

storage temp. -20°C Freezer

solubility H2O: soluble15mg/mL, clear

color white to beige

 

 

Abstract

 

(1) Rivastigmine is mainly through hydrolysis cholinesterase metabolism, cytochrome P450 isozymes are rarely involved in its metabolism. Therefore, the product and by other drugs metabolized by these enzymes does not exist pharmacokinetic interactions.


(2) study in healthy volunteers found the product (a single dose of 3mg) with digoxin, warfarin, diazepam or fluoxetine, have no pharmacokinetic interactions. Warfarin induced by prothrombin time extension are not affected by this product. After combination of digoxin and the product found no adverse impact on cardiac conduction.


(3) In clinical studies of patients with Alzheimer's disease (AD), the goods and some commonly used prescription drugs combined, such as antacids, antiemetics, hypoglycemic agents, β-blockers, calcium channel blockers agents, inotropic agents, anti-angina drugs, non-steroidal anti-inflammatory drugs, estrogens, analgesics, tranquilizers, antihistamines, etc., and risk of clinically relevant adverse reaction does not increase


(4) In view of the pharmacokinetic effect of this product, this product should not be used in combination with other cholinergic drugs, it may interfere with the activity of anticholinergic drugs.


(5) There is no experience of this product with anti Parkinson drugs, anti anxiety drugs (except for stability), antipsychotic drugs, antiepileptic drugs, antidepressant drugs.


(6) rivastigmine tartrate as a cholinesterase inhibitor, during anesthesia, it can be used to enhance succinylcholine-type muscle relaxant effect.
 

 

Benefits

Rivastigmine improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical that is important for the processes of memory, thinking, and reasoning. People with dementia usually have lower levels of this chemical.


Rivastigmine is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease.


Rivastigmine may also be used for purposes not listed in this medication guide.

 

 

COA

 

Appearance A white to off-white hygroscopic crystalline powder
Identification Should conform
Solubility Should conform
Specefic Rotation +10°~+14°(in 5mg/ml of water)
Water NMT3.0%
Heavy Metals NMT0.002%
Limit of Free Phosphate NMT0.1%
Limit of Sodium NMT0.2%
Limit of chloride NMT0.2%
Microbial Limits Test Should conform
Related substances Should conform
Residual Solvents should conform
Assay 98.0%~102.0%

 

Safe Pass Raw Materials Powder Rivastigmine Tartrate CAS 129101-54-8 For Alzheimer Disease 1

 

Dosage

The dosage of Exelon to treat Alzheimer's Disease is 6-12 mg/day, given twice-a-day. The dose to treat Parkinson's Disease is 3-12 mg/day, given twice-a-day. Exelon may interact with atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, mepenzolate, methantheline, methscopolamine, propantheline, or scopolamine. Tell your doctor all medications you are taking. During pregnancy, this medication should be used only when prescribed by a doctor. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
 

 

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