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|Product Name:||Orlistat||Other Name:||Tetrahydrolipstatin;Orlipastat|
|Appearance:||White Powder||Usage:||Fat Burning|
|CAS:||96829-58-2||Shipping Method:||EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC|
pharmaceutical active ingredients,
pharmaceutical fine chemicals
Steroid Powder Pharmaceutical Raw Materials Orlistat / Tetrahydrolipstatin / Orlipastat CAS 96829-58-2 For Fat Burning
Orlistat is a semi-synthetic derivative of lipstatin , a metabolite isolated from Streptomyces toxytricini . Orlistat acts as a potent , irreversible inhibitor of pancreatic lipase . In vivo , it blocks the absorption of triglycerides while allowing fatty acid absorption .
Orlistat is widely used for the treatment of obesity as weight loss steroids .Biological Activity Hypolipemic pancreatic , gastric and carboxylester lipase inhibitor . Exhibits no activity at phospholipase A 2 , liver esterase , trypsin and chymotrypsin . Inhibits the thioesterase domain of fatty acid synthase , leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits pro-gastrokinetic , antiobesity and antihypercholesterolemic activity in vivo .
|Appearance||White or almost white crystalline powder|
|Specific Rotation||-48° ~ -51.0°(on the anhydrous, solvent-free basis)|
|Identification||A.HPLC: The retention time of the major peak of the sample solution corresponds to that of the standard solution.|
|B.IR: The IR spectrum of sample is consistent to the reference|
|Total impurity||Not more than 1.0%|
|Related Compound A||Not more than 0.2%|
|Related Compound B||Not more than 0.05%|
|Related Compound C||Not more than 0.05%|
|Related Compound D||Not more than 0.2%|
|Related Compound E||Not more than 0.2%|
|Formyl leucine||Not more than 0.2%|
|Orlistat open ring epimer||Not more than 0.2%|
|D-Leucine orlistat||Not more than 0.2%|
|Orlistat open ring amide||Not more than 0.1%|
|Individual unidentified impurity||Not more than 0.1%|
|n-Hexane||Not more than 5000ppm|
|Isopropyl ether||Not more than 5000ppm|
|Residual on ignition||Not more than 0.1%|
|Heavy Metal||Not more than 20ppm|
|Water||Not more than 0.2%|
|Assay||98.0%~101.5% (on the anhydrous, solvent-free basis)|
|Conclusion||Conform with USP35 or EP|
Orlistat Good Effects
Orlistat's primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake.Orlistat is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini.However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug.
|Appearance||white or almost white crystalline powder,smell less|
|Identification||The result of HPLC is consisitent to the reference one. The result of IR is consisitent to the reference one.|
|Related Substances||≤ 0.5%|
|Total impurity||≤ 1.0%|
|Single impurity||≤ 0.1%|
|Isopropyl ether||≤ 5000ppm|
|Residual on Ignition||≤0.1%|
|Heavy Metal||≤ 20ppm|
|Purity||≤ 99.0% ~ 99.9%|
How well does orlistat work?
Studies have shown that, on average, orlistat, plus a weight-reducing diet and exercise, causes more weight loss than a weight-reducing diet and exercise alone. Some people lose 10% or more of their body weight within six months with the help of orlistat. In others, it is less effective.
One reason why orlistat may not work is that you may think that you can relax your weight-reducing diet, and the orlistat will 'do it all'. This is not true. In order to lose weight you still have to eat less, and exercise regularly. Remember, orlistat prevents only some of the fat that you eat from being absorbed (just under a third). But, if you do not keep to a healthy weight-reducing diet, and you eat more fat (chocolates, cakes, etc), the extra fat that you eat will easily cancel out the effect of the orlistat.
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