| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | 609799-22-6 |
| Minimum Order Quantity: | Negotiation |
| Price: | Contact Us |
| Packaging Details: | Stealth And Discreet Packaging |
| Delivery Time: | Within 7 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 100 KG/Month |
| Product Name: | Tasimelteon | Analysis Standard: | Enterprise Standard |
|---|---|---|---|
| Appearance: | White To Off-white Crystalline Powder | Alias: | Hetlioz |
| CAS: | 609799-22-6 | Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC |
| High Light: | pharmaceutical active ingredients,pharmaceutical anabolic steroids |
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Pharmaceutical Raw Materials Tasimelteon / Hetlioz CAS 609799-22-6 For good Sleep
Abstract
Tasimelteon was developed for the treatment of insomnia and other sleep disorders. A phase II trial on circadian rhythm sleep disorders was concluded in March 2005. A phase III insomnia trial was conducted in 2006. A second phase III trial on insomnia, this time concerning primary insomnia, was completed in June 2008. In 2010, the FDA granted orphan drug status to tasimelteon, then regarded as an investigational medication, for use in totally blind adults with N24HSWD.
On completion of Phase III trials, interpretations of the clinical trials by the research team concluded that the drug may have therapeutic potential for transient insomnia in circadian rhythm sleep disorders. A year-long (2011-2012) study at Harvard tested the use of tasimelteon in blind subjects with non-24-hour sleep-wake disorder. The drug has not been tested in children nor in any non-blind people.
Specification
| Product | Tasimelteon | CAS NO. | 609799-22-6 |
| Analysis Standard | Enterprise Standard | Batch No. | 20170102 |
| Testing Items | Specifications | Result | |
| Appearance | White to off-white crystalline powder | Complies | |
| Identification | HPLC: Positive IR: Positive |
Complies Complies |
|
| Loss on drying | ≤0.5% | 0.01% | |
| Residue on Ignition | ≤0.1% | 0.01% | |
| Related Substances (HPLC) | Impurity A≤0.1% Impurity B≤0.1% Impurity C≤0.1% Any other single impurity≤0.1% Total impurities≤0.5% |
N/D N/D 0.04% N/D 0.04% |
|
| Chiral Purity (HPLC) | ≥99.9% | 100% | |
| Heavy Metals | ≤10ppm | Complies | |
| Residual solvents | Ethanol≤5000ppm Tetrahydrofuran≤720ppm Ethyl acetate≤5000ppm Toluene≤890ppm |
300 ppm N/D 600 ppm 31 ppm |
|
| Assay | 98.0 - 102.0% ( on anhydrous basis) | 100.2% | |
| Conclusion | Complies with the Enterprise Standard. |
Tasimelteon is a drug approved by the U.S. Food and Drug Administration (FDA)in January 2014 for the treatment of non-24-hour sleep-wake disorder (also called Non-24, N24 and N24HSWD).In June 2014, the European Medicines Agency accepted an EU filing application for tasimelteon and in July 2015, the drug was approved in Europe for the treatment of non-24-hour sleep-wake rhythm disorder in totally blind adults,but not in the rarer case of non-24 in sighted people.
Tasimelteon is a selective agonist for the melatonin receptors MT1 and MT2, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved.As a treatment for N24HSWD, as with melatonin or other melatonin derivatives, the patient may experience improved sleep timing while taking the drug. Reversion to baseline sleep performance occurs within a month of discontinuation.
Important safety information
Tasimelteon may cause drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use tasimelteon with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking tasimelteon; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
Tasimelteon may take several weeks or months to work. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Use tasimelteon with caution in the ELDERLY; they may be more sensitive to its effects.
Tasimelteon should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING
If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking tasimelteon while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you take tasimelteon, check with your doctor. Discuss any possible risks to your baby.
| Competitive Advantage | |
| Professional Packing | Professional packing with professional materials, and we will give clients several packing way to choose after you contact me through my email |
| Quality Assurance | Our extensive relationship with manufacturers in China, allow us to bring you the highest quality chemicals, ingredients, and additives at a superior price. The more you buy the more competitive prices you will get. |
| Competitive Price | Our extensive relationship with manufacturers in China, allow us to bring you the highest quality chemicals, ingredients, and additives at a superior price. The more you buy the more competitive prices you will get. |
| In time Delivery: | We promise to deliver each batch of products in time, and with the target that deliver satisfaction rate arrive to 100%. |
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| How to make order | ||
| step1 | Pre-sale service | 1.As for your every inquiries, we always reply timely and patiently. All of the relevant information will be provided to help you to make a wise choice |
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