| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | 148553-50-8 |
| Minimum Order Quantity: | Negotiation |
| Price: | Contact Us |
| Packaging Details: | Stealth And Discreet Packaging |
| Delivery Time: | Within 7 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 100 KG/Month |
| Product Name: | Pregabalin | Other Name: | Pregablin |
|---|---|---|---|
| MF: | C8H17NO2 | MW: | 159.23 |
| EINECS: | 200-659-6 | Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC |
| High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
||
Pharmaceutical Raw Materials Pregabalin / Pregablin CAS 148553-50-8 For Treatment Antiepileptic Drugs
CAS: 148553-50-8
MF: C8H17NO2
MW:159.23
EINECS: 200-659-6
Synonyms: 3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;(3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;PREGABALIN;Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid;PREDNISOLONESODIUMPHOSPHATE;(R)-Pregabalin;(S)-Pregabalin
Melting point: 194-196°C
Flash point: 9℃
storage temp. Store at RT
solubility deionized water: ≥10mg/mL
Symbol(GHS)
Abstract
Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is a long-term condition where anxiety is a major symptom.
Pregabalin, also known as β-isobutyl-γ-Aminobutyric acid (β-isobutyl-GABA) and sold under the trade name Lyrica among others, is a medication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.
Pregabalin is a structural analogue of the neurotransmitter GABA, consequently it belongs to the γ-Aminobutyric acid analogue class of antiepileptic drugs. Its a ion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is a potent gabapentinoid and close analogue of GABOB (β-hydroxy-GABA), baclofen (β-(4-chlorophenyl)-GABA), and phenibut (β-phenyl-GABA).
COA
ITEMS |
STANDARDS |
RESULTS |
Appearance |
A white to off white powder |
White powder |
Identification |
A. Meets the requirement |
Complies |
B. IR: similar to Reference Substance |
Complies |
|
Loss on drying |
≤0.5% |
0.21% |
Specific Rotation |
+10.0°~+13.0° |
+10.8° |
Related Substances |
Any single impurity ≤0.1% Total impurity ≤0.8% |
0.05% 0.10% |
Purity By HPLC R-isomer |
≤0.15% |
0.10 |
Residue on ignition |
≤0.1% |
0.05% |
Residual solvents |
Isopropyl alcohol ≤5000ppm Ethyl Acetate ≤5000ppm |
150ppm 250ppm |
Heavy metals |
≤10ppm |
Complies |
Chlorides |
≤0.05% |
Complies |
Assay |
98%~102.0% |
99.8% |
Conclusion |
Analyse according to Factory Standard , Conform |
|
Pregabalin is indicated for
1.Treatment of neuropathic pain from diabetic neuropathy or post herpetic neuralgia. There is not enough data to state that it should be used in all neuropathic pain.
2. Adjunctive therapy in adults with partial seizures with or without secondary generalization
3. Fibromyalgia
4. Generalized anxiety disorder
5. Alcohol Withdrawal
Usually physicians will start the patient on a low dose of pregabalin and increase it gradually, depending on the patient's evaluation. Its therapeutic effect appears after 1 week of use and is similar in effectiveness to lorazepam, alprazolam and venlafaxine but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.
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