Pharmaceutical Raw Materials Levamisole hydrochloride CAS 16595-80-5 For Parasitic Worm Infections

CAS: 16595-80-5

MF: C11H13ClN2S

MW: 240.75

EINECS: 240-654-6

Synonyms: 1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(s)-imidazo( ;1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,l-(-)-imidazo( ;1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)-Imidazo[2 ;citarinl ;decaris ;Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)- ;kw-2-le-t ;L-2,3,5,6-Tetrahydro-6-phenylimidazo-[2,1-6]-thiazole

Melting point:266-267 °C(lit.)

alpha -128 º (c=5, H2O)

refractive index -126 ° (C=1, H2O)

Flash point:9℃

storage temp. 0-6°C

form Crystalline Powder

color White to almost white

Water Solubility 210 g/L (20 ºC)

Merck 5459

Symbol(GHS)

Signal word Danger

Abstract

Levamisole HCL is absorbed through the gut, can also be absorbed through the skin and is distributed throughout the body.

Levamisole affects the neurotransmitters and paralyzes the worm (spastic paralysis). The fish then passes the inactive worms. Good gravel vacuuming is advised after treatment to remove the paralyzed (but still live) worms.

It is not ovicidal, which means it will not affect eggs already present, but it will affect the larval stage of the worm. To ensure complete eradication of the parasite treat again after remaining eggs have hatched.

 

How does Levamisole HCL work as an immunomodulator?

The mechanism of action for its immunostimulating effects are not well understood. It is believed that it restores cell-mediated immune function in peripheral T-lymphocytes and stimulates phagocytosis by monocytes.

The drug appears to restore depressed immune function rather than to stimulate
response to above-normal levels. There are multitudes of medical studies being done with its use in humans and animals, the goal being to attain understanding of its immunomodulating mechanism. The mechanism will be defined, with time.

How does Levamisole HCL work as an antiparasitic agent?

Levamisole HCL is absorbed through the gut, can also be absorbed through the skin and is distributed throughout the body.

Levamisole affects the neurotransmitters and paralyzes the worm (spastic paralysis). The fish then passes the inactive worms. Good gravel vacuuming is advised after treatment to remove the paralyzed (but still live) worms.

It is not ovicidal, which means it will not affect eggs already present, but it will affect the larval stage of the worm. To ensure complete eradication of the parasite treat again after remaining eggs have hatched.