Pharmaceutical Raw Materials Smart Drug Galantamine Hydrobromide / Galanthamine HBR For Alzheimer′s Disease

CAS: 1953-04-4

MF: C17H22BrNO3

MW: 368.27

EINECS: 217-780-5

Synonyms: GALANTHAMIDE HYDROBROMIDE;GALANTHAMINE HBR;GALANTHAMINE HYDROBROMIDE;galanthamine hydrobromide from lycoris sp.;Galanthamine Hydrobromide Injection;GALANTHAMINE HYDROBROMIDUM;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide;(-)-Galanthaminium bromide

Melting point:256 °C

alpha D20 -93.1° (c = 0.1015 in 15 ml H2O)

refractive index -95 ° (C=1.4, H2O)

storage temp. −20°C

Water Solubility Soluble in water or DMSO

Merck 4340

Symbol(GHS)

Abstract

Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other
memory impairments, particularly those of vascular origin. It is an alkaloid that is obtained synthetically or from the bulbs and flowers of Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus (daffodil)), Leucojum(snowflake) and Lycoris including Lycoris radiata (Red Spider Lily).

Galanthamine is natural extracted from lycoris radiate,is a tertiary alkaloid derived from snow drop and closely related species. It acts as a reversible competitive acetylcholinesterase (ACHE) inhibitor, while acts weaker on butyrylcholinesterse(BuChE).it is used in the treatment of disorders of the central nerbous system and may be used as an antidote to nonpolarizing muscle relaxants.Galanthamine hydrobromide is a white to almost white powder; sparingly soluble in water; insoluble chloroform, ether and alcohol .

Function

1) Anti-oxidation series:
bilberry extract, cranberry extract, grape seed extract, elderberry extract, lutein, zeaxanthin, pine bark extract, rosemary extract, pine bark extract. lemon balm extract.

2) Liver protecting:
silybum marianum extract, artichoke extract, antrodia camphorate extract, schisandea extract.

3) Immune system enhancer series:
wolfberry extract, echinacea extract, tribulus terrestris extract, resveratrol, 5htp, citrus aurantium extract, nettle extract, red cover extract, reishi extract, rhodiola rosea extract, black cohosh extract, astragalus extract, ginseng extract, cinnamomum cassia extract, schisandra chinensis extract.

4) Heat-clearing and detoxifying series:
lemon balm extract, dandelion extract.

5)Weight loss series:
white kidney bean extract, garcinia cambogia extract, cassia nomame extract, 5htp.

6)Man and woman healthy:
yohimbe bark extract, common cnidium extract, epimedium extract, pygeum africanum extract, saw palmetto extract, soybean extract, pueraria lobata extract, wild yam extract.

7) Mushroom extract:
reishi extract, maitake extract, shitake extract, cordceps extract.

8) Anti-cancer:
resveratrol, wolfberry extract, flaxseed extract, pomegranate extract, bilberry extract.

9) Anti-depressant:
passiflora incarnate extract, st john's wort extract.

10) Antibacterial:
white willow bark extract, citrus aurantium extract, pomegranate extract, senna extract, magnolia extract, ginger extract, scutellaria baicalensis extract, shikimic acid,echinacea purpurea extract, chlorogenic acid.
 

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