High Purity Effective Diuretic Furosemide / Lasix 99% Raw Material Powder

Furosemide

Product Information:

Product Name: Furosemide
 

Synonyms: LABOTEST-BB LT00244801;FUROSEMID;FUROSEMIDE;FRUSEMIDE;2-

furfurylamino-4-chloro-5-sulfamoylbenzoic acid;4-CHLORO-N-FURFURYL-5-

SULFAMOYLANTHRANILIC ACID;5-(AMINOSULPHONYL)-4-CHLORO-2-[(2-

FURANYLMETHYL)AMINO]BENZOIC ACID;5-[AMINOSULFONYL]-4-CHLORO-2-[(2-

FURANYLMETHYL)AMINO]BENZOIC ACID
 

CAS: 54-31-9
 

MF: C12H11ClN2O5S
 

MW: 330.74
 

EINECS: 200-203-6
 

Product Categories: Organics;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Ion

transporter and other ion channel;GABA;Aromatics;Heterocycles;Sulfur & Selenium

Compounds;API;LASIX;Other APIs

Chemical Properties:
 

Melting point 220 °C (dec.)(lit.)
 

density 1.606
 

Fp 11 °C
 

storage temp. 2-8°C
 

Water Solubility Soluble in acetone, DMF or methanol. Slightly soluble in water
 

Merck 14,4309
 

Stability: Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong

oxidizing agents.

Safety Information:
 

Hazard Codes T,F,Xi
 

Risk Statements 61-39/23/24/25-23/24/25-11-36/37/38
 

Safety Statements 7-16-36/37-45-53-36/37/39-22-36-26
 

RIDADR UN 1230 3/PG 2
 

WGK Germany 3
 

RTECS CB2625000

Usage And Synthesis:
 

Efficient diuretics Furosemide, is a class of efficient sulfonamide diuretics acting on the

medullary loop of the ascending branch of the medulla,it has a strong and short-term diuretic

effect,which can increase the excretion of water, sodium, chloride, potassium, calcium,

magnesium, phosphate and so on. It Mainly inhibits Na + and Cl-reabsorption in medullary and

cortex of the medullary loop ascending branch crude segment , it can promote the excretion of

sodium, chloride and potassium and affect the formation of renal medullary high osmotic

pressure,it can interfer the process of concentration and dilution of urine, and it can increase

urine output. This product can inhibit the activity of prostaglandin decomposition enzyme ,make

the content of prostaglandin E2 increase,it has effect on expansion of blood vessels, it also plays

a role in the proximal tubule, glomerular filtration,it can increase renal blood flow,and adjust renal

blood flow distribution,and reduce blood flow so that the cortex surface blood flow increases,it

promotes diuresis, its effect is fast and strong, it is used for other diuretics invalid cases.

Clinically it is used for the treatment of cardiac edema, renal edema, cirrhosis ascitic fluid,

peripheral edema caused by dysfunction or vascular disorders , and it may contribute to an upper

urinary tract stones excretion. Administration intravenously can treat brain edema, it also can

accelerate the excretion of toxic substances in cerebral edema in poisoning . Note that when the

diuretic furosemide is used, since the excretion of urine Cl-, Na +, K +, H + is increasing, while

the excretion of HCO3-is not increasing, long-term repeated drug use or large quantities of drugs

can cause low salt syndrome, low chlorine and low potassium alkalosis.
 

In recent years, researchers find that inhalation of furosemide can have a significant effect on

asthma, it is like cromolyn sodium, which through inhibition of allergic mediator release, it can

inhibit the release of the neurotransmitter acetylcholine and substance P, which may be related to

inhibiting chloride ions into the cell membranes of respiratory tract. Clinically,it is used in

exercise-induced asthma, immediate and delayed type antigen-induced asthma.
 

Chemical properties white or white alike crystalline powder. 206 ℃ melting point. Dissolved in

acetone, methanol, dimethyl formamide, slightly soluble in ethanol, insoluble in water. Odorless,

almost tasteless.
 

Uses The diuretic effect of this product is a strong and short,it is a potent diuretic for the treatment

of edema caused by heart, liver, kidney and other diseases, in particular, the base cases which

other diuretics are invalid to;it can be used to treat acute pulmonary edema, brain edema , acute

renal failure and high blood pressure and other diseases; in combination with fluid infusion, the

product can promote poison excretion. Rat oral LD50 is 2600-2820mg/kg.
 

production method 2,4-dichlorobenzoic acid (see 12740) by sulfochlorination,ammoniation,

acidification ,dichloro-5-sulfamoyl-benzoic acid is obtained. Then after condensation with the

chaff amine , furosemide is produced.
 

Category Toxic substances
 

Toxicity grading Middle toxic
 

Acute toxicity Oral-rat LD50: 2600 mg/kg; Oral-Mouse LD50: 2200 mg/kg.
 

Flammability and hazard characteristics Combustible; fire decomposition produces toxic

nitrogen oxides; sulfur oxides and chlorides smoke.
 

Storage Characteristics Ventilated, low-temperature ,dry storeroom.
 

Extinguishing agent Water, carbon dioxide, dry powder,sandy soil.
 

Chemical Properties white to light yellow crystal powde
 

Uses diuretic, antihypertensive
 

Uses Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic.
 

Uses This compound belongs to the aminobenzenesulfonamides. These are organic compounds

containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
 

Uses An inhibitor of NKCC and a GABAA receptor antagonist.
 

General Description Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost

tasteless.
 

Air & Water Reactions Light sensitive. Air sensitive. Slightly soluble in water.
 

Reactivity Profile Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous

solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown

to improve the stability of Furosemide. Incompatible with strong oxidizing agents .
 

Fire Hazard Flash point data for Furosemide are not available; however, Furosemide is probably

combustible.
 

Biological Activity Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts

as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-

containing receptors than α 1-containing receptors.

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