| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | 29767-20-2 |
| Minimum Order Quantity: | 1g |
| Price: | Negotiable ( Discounts For Big Order ) |
| Packaging Details: | Stealth And Discreet Packaging |
| Delivery Time: | Within 7 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 2 KG/Month |
| Product Name: | Teniposide | CAS: | 29767-20-2 |
|---|---|---|---|
| MF: | C32H32O13S | MW: | 656.65 |
| EINECS: | 249-831-2 | Grade Standard: | Medicine Grade |
| Type: | Auxiliaries And Other Medicinal Chemicals | Purity: | 99% |
| High Light: | pharmaceutical active ingredients,pharmaceutical anabolic steroids |
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Teniposide
| Product Name: | Teniposide |
| CAS: | 29767-20-2 |
| MF: | C32H32O13S |
| MW: | 656.65 |
| EINECS: | 249-831-2 |
| Teniposide Chemical Properties |
| Melting point | 244-247°C |
| alpha | D20 -107° (9:1 chloroform/methanol) |
| Boiling point | 650.86°C (rough estimate) |
| density | 1.2568 (rough estimate) |
| refractive index | 1.5530 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 10.13(at 25℃) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1) |
| λmax | 283nm(MeOH)(lit.) |
| Merck | 14,9145 |
| Teniposide Usage And Synthesis |
| Chemical Properties | White Solid |
| Uses | A labelled semi-synthetic derivative of Podophyllotoxin. Antineoplastic. |
| Uses | A semi-synthetic derivative of Podophyllotoxin. Antineoplastic. |
| Definition | ChEBI: A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding. |
| Uses | Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis. Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia. |
| Brand name | Vumon (Bristol-Myers Squibb). |
| General Description | Teniposide is available in 50-mg ampules with Cremophor ELfor IV administration in the treatment of acute lymphoblasticleukemia (ALL). The agent is more potent as an inhibitor oftopoisomerase II. The pharmacokinetics of teniposide issimilar to that of etoposide; however, the more lipophilic teniposideis more highly protein bound (99%) and less isexcreted unchanged in the urine (10%–20%). There is alsogreater overall metabolism of teniposide; however, CYP3A4-mediated conversion to the active catechol is slower comparedwith etoposide. Elimination occurs primarily in the urine witha terminal elimination half-life of 5 hours. |
| Safety Profile | Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion and intravenous route: anorexia, nausea or vomiting, leukopenia, agranulocytosis and aplastic anemia of the blood, bone marrow changes, and hair changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. |
__________________________ For Your Reference ______________________________
Place of origin : China
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Quality Standard : USP
Minimum Order Quantity : 10 g
Production Capacity : 1000 Kg/Month
_____________________________ Package & Delivery ______________________________
Package : Foil bag, Foil tin , Drum or as your request
Payment Method : T/T, Western Union, MoneyGram
Shipping Method : EMS, DHL, FeDex, UPS
Leading time : Within 48 hours after confirming payment
Delivery time : Within 7 working days after confirming payment
______________________________ Why Choose Us ? ______________________________
1. Quality : we deal with steroid relevant products over 15 years, and have many stable customers from all over the world. All of them witness our products' quality.
2. Package : Different package for different customs results in high rate of customs clearance.
3. Delivery: No matter where you are from, safe delivery will be finished within 7 working days.
4. Guarantee: Reship policy will be shown to you before your order. The more you buy, the more discounts you will enjoy.
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