Anti-Inflammatory & Pain Killer Agent Indometacin Powder With BP Standard CAS: 53-86-1

Indometacin  CAS: 53-86-1

Basic Details:

Product Name: Indometacin
CAS: 53-86-1
MF: C19H16ClNO4
MW: 357.79
EINECS: 200-186-5
Melting point 155-162 °C
storage temp. Store at RT
solubility ethanol: 50 mg/mL, clear, yellow-green
pka 4.5(at 25°C)
Water Solubility Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
Sensitive Light Sensitive
Stability: Stable. Incompatible with strong oxidizing agents.

Description:
Indomethacin is a kind of stronger corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reducing the synthesis of prostaglandin (PG), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., and produce antipyretic, analgesic and anti-inflammatory effects.

Indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect is better than bute, 84 times better than hydrocortisone, and sugar cortical hormone, used in combination with aspirin, bute, can reduce their dosage, toxic and side effects, improve curative effect;

Second is antipyretic effect, 10 times than amidopyrine ;its analgesic action is weak , only to the inflammatory pain has obvious analgesic effect, but the effect is good for inflammatory pain than Baotai loose, analgin and salicylic acid.
 

COA :

Application:

Clinical is mainly used for the salicylic acid, drugs are less tolerance or curative effect is not obvious in the acute and chronic rheumatic or rheumatoid arthritis, ankylosing spondylitis, slippery bursa phlogistic, tenosynovitis, articular capsulitis, osteoarthritis and acute gout and cancerous pain, etc.

In recent years, the researchers try to use indomethacin biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, orthostatic hypotension, bart syndrome and so on, all have good curative effect.

It can also be used to treat eye pigment meningitis, keratitis, scleritis, glaucoma and fever caused by cancer or other difficult to control the fever.

Dermatologist for lupus erythematosus (sle), white plug syndrome, scleroderma, nodular erythema, herpes zoster, joint type of psoriasis, etc. photosensitive dermatitis induced by topical treatment of eczema, allergic dermatitis, and local pain.

Clinical indications for indometacin include:
ankylosing spondylitis
arthritic gout
Bartter syndrome
bursitis
cryoglobulinemia
dysmenorrhea (menstrual cramps)
fever and pain associated with malignant diseases (especially tumor fever associated with liver involvement, lymphogranulomatosis)
headaches caused by the Valsalva maneuver
hemicrania continua
hypnic headache
juvenile arthritis
migraine
nephrogenic diabetes insipidus (prostaglandin inhibits vasopressin's action in the kidney)
osteoarthritis
Paget's disease of bone
paroxysmal hemicrania
patent ductus arteriosus
pericarditis
primary exertion headache
primary stabbing headaches
pseudogout
psoriatic arthritis
reactive arthritis
renal colic (pain due to kidney stones)
retinopathy of prematurity
rheumatoid arthritis
tendinitis
trigeminal autonomic cephalgias
Indometacin has also been used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to close patent ductus arteriosus.
Indometacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The medication is better described as an anti-inflammatory, rather than an analgesic. Indometacin can also affect warfarin and subsequently raise INR.