99% Top Quality Anti-hypertension Pharmaceutical Raw Material Candesartan Cilexetil Powder CAS: 145040-37-5

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 145040-37-5
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 1000kg per month
Product Name: Candesartan Cilexetil CAS: 145040-37-5
MF: C33H34N6O6 MW: 610.66
EINECS: 1592732-453-0 Melting Point: 168-170°C
Appearance: White Powder
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                                    Candesartan Cilexetil
 
 
 
Quick Detail:

Product Name
Candesartan cilexetil
Synonym
Candesartan cilexeti;Candesartan Celexetil Ester; Candesartan Cilexetil;Candesartan Cilexetil API;1-(((Cyclohexyloxy) carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-et;2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;
CAS
145040-37-5
MF
C33H34N6O6
MW
610.66
EINECS
1592732-453-0
Purity
99%
Appearance
White powder
Melting Point
168-170°C
Grade
Pharma Grade
Certificaton
ISO 9001, USP
Standard
Enterprise Standard
Usage
Anti-hypertensive/Anti-anginal
MOQ
10g

 


Description:
Candesartan cilexetil, a nonpeptide, is chemically described as (±)-1-Hydroxyethyl 2-ethoxy-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester).
Candesartan cilexetil is a white to off-white powder with a molecular weight of 610.67. It is practically insoluble in water and sparingly soluble in methanol. Candesartan cilexetil is a racemic mixture containing one chiral center at the cyclohexyloxycarbonyloxy ethyl ester group. Following oral administration, candesartan cilexetil undergoes hydrolysis at the ester link to form the active drug, candesartan, which is achiral.

 


Application:
Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough.


Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
 
 
COA:

ITEMS SPECIFICATION
TESTRESULTS
Appearance Off-white or white powder
Conforms
Identification HPLC,NMR;LC-MS
Conforms
Related substances Individual impurity≤0.5%
0.09%
Total impurities≤1.0%
0.20%
Loss on drying ≤0.5%
0.3%
Residue on ignition ≤0.1%
0.04%
Heavy metals ≤10ppm
Conforms
Assay ≥98.0 %
99.1%


 
Use:
Anti-hypertensive/Anti-anginal.
Ester prodrug
hydrolized in vivo to the active carboxylic acid.
Used in treatment of congestive heart failure.

 


Our Advantage:
 

1. Quality assurance
With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

 

2. Safe transportation
Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

 

3. The product diversity
Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

 

4. High quality service
Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

 

 

 

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2-(Aminoacetylamino)-3-(o-chlorobenzoyl)-5-ethylthiophene 50509-09-6
Baricitinib Series Baricitinib API 1187594-09-7 Rheumatoidarthritis
(RA)
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7h-pyrrolo[2,3-d]pyrimidine 941685-27-4
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Apixaban Series Apixaban API 503612-47-3 Thromboprophylaxis
3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-on 545445-44-1
3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone 503615-03-0
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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 503614-91-3
ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 503615-07-4
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3
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