Anti-cancer Drug Teniposide Powder CAS: 29767-20-2 Medicine Grade 99%

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 29767-20-2
Minimum Order Quantity: 1g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 4 KG/Month
Product Name: Teniposide CAS: 29767-20-2
MF: C32H32O13S MW: 656.65
Appearance: White Solid Usage: Anti-cancer
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Anti-cancer Drug Teniposide Powder CAS: 29767-20-2 Medicine Grade 99% 0





Product Name: Teniposide
CAS: 29767-20-2
MF: C32H32O13S
MW: 656.65
EINECS: 249-831-2
Product Categories: Carbohydrates & Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds;VUMON;API;Inhibitors;Active Pharmaceutical Ingredients
Teniposide Structure
Chemical Properties
Melting point 244-247°C
alpha D20 -107° (9:1 chloroform/methanol)
Boiling point 650.86°C (rough estimate)
density 1.2568 (rough estimate)
refractive index 1.5530 (estimate)
storage temp. -20°C Freezer
solubility DMSO: soluble10mg/mL, clear
pka 10.13(at 25℃)
form powder
color white to beige
optical activity [α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1)
λmax 283nm(MeOH)(lit.)
Usage And Synthesis
Appearance White Solid
Uses A labelled semi-synthetic derivative of Podophyllotoxin. Antineoplastic.
Uses A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.
Uses Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis. Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.
Definition ChEBI: A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.
General Description Teniposide is available in 50-mg ampules with Cremophor ELfor IV administration in the treatment of acute lymphoblasticleukemia (ALL). The agent is more potent as an inhibitor oftopoisomerase II. The pharmacokinetics of teniposide issimilar to that of etoposide; however, the more lipophilic teniposideis more highly protein bound (99%) and less isexcreted unchanged in the urine (10%–20%). There is alsogreater overall metabolism of teniposide; however, CYP3A4-mediated conversion to the active catechol is slower comparedwith etoposide. Elimination occurs primarily in the urine witha terminal elimination half-life of 5 hours.
Safety Profile Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion and intravenous route: anorexia, nausea or vomiting, leukopenia, agranulocytosis and aplastic anemia of the blood, bone marrow changes, and hair changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx.



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