China Antiandrogen Bicalutamide Powder CAS: 90357-06-5 Treatment For Prostate Cancer

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 90357-06-5
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 200 KG/Month
Product Name: Bicalutamide CAS: 90357-06-5
MF: C18H14F4N2O4S MW: 430.37
Melting Point: 191-193°C Appearance: Off-white Crystalline Powder
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China Antiandrogen Bicalutamide Powder CAS: 90357-06-5 Treatment For Prostate Cancer 0

 

Bicalutamide

 

 

Basic Details:

Product Name: Bicalutamide
Synonyms: (+-)--2-hydroxy-2-methyl;propanamide,n-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl);ICI-176334;CASODEX;BICALUTAMIDE;N-[(4-CYANO-3-TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPANAMIDE;N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPIONANILIDE;Bicalutamide (Subject to patent free)
CAS: 90357-06-5
MF: C18H14F4N2O4S
MW: 430.37
Melting point 191-193°C
storage temp. Store at RT
solubility DMSO: >5mg/mL
λmax 270nm(CH3CN)(lit.)
Merck 14,1200

 

 

 

Tablets:
Bicalutamide tablet is a non-steroidal androgen antagonist, which competes androgen receptor with the androgen, blocks cellular uptake of androgen, and inhibits the binding of androgens to the target organ. It binds with the androgen receptor that forms receptor complex, which enters the nucleus and combined with the nucleoprotein, consequently inhibiting tumor cell growth. It can be as a first-line drug for palliative treatment of advanced prostate cancer.


Dosage and administration:
Adult: adult males including the elderly: one (50mg), once a day. The treatment should be started simultaneously with LHRH analogue therapy or surgical orchiectomy.

 

Children: This product is contraindicated in children.
Renal impairment: The patients with renal impairment don't need dose adjustment.
Hepatic impairment: The patients with mild liver damage don't need dose adjustment, while the patients with severe liver damage may occur drug accumulation (see precautions).


Precautions:
This product is widely metabolized in the liver. Data show that patients with severe liver damage may slow down drug clearance, which may lead to accumulation. So the patients with moderate and severe liver injury should use it with caution.
The patients may appear liver changes by using it, so it should be considered regular liver function tests. The main changes generally appear within the first 6 months of treatment using this product.

Severe changes in liver function are rarely visible in the treatment of the product (see Adverse Reactions). If there is a serious change in treatment using this product, it should be discontinued .


Uses:
V1 taking anti-androgens drug. Prostate cancer therapeutic agents for the treatment of advanced prostate cancer.

 

 

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