99% Purity Safe Delivery Clobetasol Propionate CAS: 25122-46-7 For Anti-inflammatory

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 25122-46-7
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 1000kg per month
Product Name: Clobetasol Propionate EINECS: 246-634-3
CAS: 25122-46-7 MF: C25H32ClFO5
MW: 466.97 Appearance: White Crystalline Powder
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Product name: Clobetasol propionate
Synonyms: 17-propionate; cgp9555; clobesol; pregna-1, 4-diene-3, 20-dione, CLOBESTASOL PROPIONATE; CLOBETASOL-17-PROPIONATE; Clovate; Clonovate;
CAS No.: 25122-46-7
EINECS No.: 246-634-3
Molecular formula: C25H32ClFO5
Molecular weight: 466.97
Quality standard: USP33
Assay: 97.0%-102.0%
Grade: medical grade
Chemical Properties: white to yellowish crystalline powder. This product is easily soluble in chloroform, dissolved in ethyl acetate in methanol or ethanol, slightly soluble in water, insoluble.
Use: Topical corticosteroid; Glucocorticoid; Anti-inflammatory


Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis,psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.


Clobetasol proprionate is used cosmetically by dark-skinned women for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, it is often sold in U.S. retail beauty supply stores and on the internet. It is also sold internationally, and does not require a prescription in some countries. Whitening creams with clobetasol proprionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body’s natural steroids, and stretch marks, which may be permanent.


Clobetasol propionate is with mercury and hydroquinone "amongst the most toxic and most used agents in lightening products." Many products sold illegally have higher concentrations of clobetasol propionate than is permitted for prescription drugs.



Standard adopted USP38
Items of analysis Specification Results
Description White or almost white crystalline powder Almost white crystalline powder
Solubility Practically insoluble in water,slightly soluble in benzene and diethyl ether ,sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane Complies
Identification (IR) Complies with the Standard Complies
Specific Rotation +98°~+104°
Melting point about 196ºC 195.0ºC~197.0ºC
Loss on drying ≤2.0%
Residue on ignition ≤ 0.1%
max. 0.1%
Heavy Metals ≤20ppm
Single impurity ≤1%
N.m.t 1.0%
Sum impurity ≤2.5%
N.m.t 2.5%
Organic volatile impurities
meet the ICH requirement
Assay(HPLC,basisondrying) 98.5%~102.0%
THF ≤720ppm
Not more than 720ppm
Methanol ≤3000ppm
Not more than 3000ppm
DMF ≤880ppm
Not more than 880ppm
Pyridine ≤ 200ppm
Not more than 200ppm
Dichloromethane ≤600ppm
Not more than 600ppm
Ethanol ≤5000ppm
Not more than 5000ppm
Acetone ≤5000ppm
Not more than 5000ppm


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99% Purity Safe Delivery Clobetasol Propionate  CAS: 25122-46-7 For Anti-inflammatory 0


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