Glucocorticoid Drug Triamcinolone acetonide 21-acetate CAS: 3870-07-3 Used For Antiasthmatic & Antiallergic

 
                  Triamcinolone acetonide 21-acetate
 
 
Basic Information:
Product Name: Triamcinolone acetonide 21-acetate
Synonyms: 9-fluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregna-1,4-diene-
3,20-dione 21-acetate;9-Fluoro-11b,21-dihydroxy-16a,17-(isopropylidenedioxy)pregna-1,4-
diene-3,20-dione 21-acetate;Triamcinolone acetonide 21-acetate;21-(Acetyloxy)-9-fluoro-11β
-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;9-fluoro-
11β,21-dihydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-
acetate;Triamcinolone aceton;21-(Acetyloxy) TriaMcinolone Acetonide;20-dione 21-acetate
CAS: 3870-07-3
MF: C26H33FO7
MW: 476.5344232
EINECS: 223-388-5
Appearance: White Solid
 
 
Description:
Glucocorticoid Triamcinolone acetonide acetate ,as a glucocorticoid drug, is white or
almost white crystalline powder, which is odorless and bitter taste. It is slightly soluble
in water, ethanol and acetone and soluble in chloroform. It is currently a long-acting
glucocorticoid drug widely used in our dermatology clinical application, also known as
Block technique, triamcinolone acetonide, Connor music cream and Conor-A. It belongs to
adrenocortical hormones drugs and s from the triamcinolone. The effects of glucocorticoid
triamcinolone acetonide acetate, similar to the role of triamcinolone, includes anti-
inflammatory, anti-allergic, anti-itching and contracting capillaries. The role of its
water and sodium retention is weak, while the anti-Inflammatory and anti-allergic effects
are stronger and more durable than hydrocortisone (10 to 30 times) and prednisone. Its
application in aerosol inhalation treatment of bronchial asthma is strong and lasting. The
local curative effect is better than the triamcinolone. Oral is easy to absorb. Oral
administration is 5mg and the bioavailability is about 23%. Its plasma concentration
reaches the peak value of 105mg/ml after 1 hour, with a half-life of 2 hours. The
intramuscular injection has a slow absorption process, and its effects begin within a few
hours, reach to the maximum after 1 or 2 days and last about 2 or 3 weeks; the intradermal
and intra-articular injection of this drug has slow-absorption and lasting-effects and the
general effects of one injection can be maintained for 1 to 2 weeks or more. This drug
binds with plasma albumin less, metabolizes into non-active metabolites in the liver,
kidney and tissue and finally is excreted by the kidneys. Local injection can also have a
lasting effect, as well as ointment topical. Clinically, the triamcinolone acetonide is
mainly used for the treatment of various skin diseases such as atopic dermatitis, contact
dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen
planus and other skin diseases and skin pruritus, as well as many infectious diseases
including bronchial asthma, rheumatoid arthritis, acute sprain, chronic low back pain,
scapulohumeral periarthritis, tenosynovitis, eye inflammation, oral mucosal hyperemia,
erosions, ulcers, granulomatous cheilitis and oral mucosa. It can also be used in the local
injection of some small area damages like keloid, cystic acne, discoid lupus erythematosus
and alopecia areata. Triamcinolone acetonide acetate nasal spray can be used for the
prevention and treatment of perennial and seasonal allergic rhinitis and vasomotor
rhinitis. Its intra-articular injection can eliminate inflammation and relieve the pain,
swelling or stiffness felling.
 
 
Uses:
1. Triamcinolone acetonide acetate can be used for eczema and dermatitis and is currently a
long-acting glucocorticoid drug widely applied in the dermatology clinical application of
China. It derives from triamcinolone and plays a similar role.
 
2. Derivative of Triamcinolone Acetonide, a glucocorticoid, antiasthmatic (inhalant);
antiallergic (nasal).
 
 
Packing&Storage