Pharmaceutical Raw Material Losartan Potassium Powder CAS: 124750-99-8

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 124750-99-8
Minimum Order Quantity: 100g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 1000kg per month
Product Name: Losartan Potassium CAS: 124750-99-8
MF: C22H23ClKN6O MW: 462.01
Appearance: White To Off-White Crystalline Powder
High Light:

pharmaceutical active ingredients

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pharmaceutical fine chemicals

Product Name: Losartan potassium
Synonyms: 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL;2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT;COZAAR;DUP 753;LOSARTAN MONOPOTASSIUM SALT;LOSARTAN POTASSIUM;LOSARTAN POTASSIUM SALT
CAS: 124750-99-8
MF: C22H23ClKN6O
MW: 462.01
EINECS: 200-287-4
Product Categories: Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;Losartan;APIS;Aromatics;Heterocycles;API Reference Standard;COZAAR;Cardiovascular APIs;API
Mol File: 124750-99-8.mol
 

 

 
Melting point 263-265°C
storage temp. Desiccate at RT
Merck 14,5583
InChIKey OXCMYAYHXIHQOA-UHFFFAOYSA-N
CAS DataBase Reference 124750-99-8(CAS DataBase Reference)

 

 
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39
RTECS NI6755100
Hazardous Substances Data 124750-99-8(Hazardous Substances Data)


 

Description As a angiotensin II receptor antagonist, Losartan Potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. It functions by relaxing blood vessels so that blood can flow more easily. It is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. Besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
Chemical Properties White to Off-White Crystalline Powder
Uses A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Uses antihypertensive, AT1 angiotensin II antagonist
Uses Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).
Brand name Cozaar (Merck).
Biological Activity Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.

 

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