Anti-cancer Drug Raw Powder Dasatinib CAS: 302962-49-8 High Purity Pharmaceutical Raw Material

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 302962-49-8
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 50 KG/Month
Product Name: Dasatinib Other Name: BMS-354825
CAS: 302962-49-8 MF: C22H28ClN7O3S
MW: 488.01 EINECS: 1806241-263-5
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pharmaceutical active ingredients

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Dasatinib

 

 

Basic Information:

Product Name: Dasatinib
Synonyms: Dasatinib(BMS-354825);BMS-354825;N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-;Dasatinib;N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide;2-{6-[4-(2-HYDROXY-ETHYL)-PIPERAZIN-1-YL]-2-METHYL-PYRIMIDIN-4-YLAMINO}-THIAZOLE-5-CARBOXYLIC ACID (2-CHLORO-6-METHYL-PHENYL)-AMIDE
CAS: 302962-49-8
MF: C22H28ClN7O3S
MW: 488.01
EINECS: 1806241-263-5
Melting point: 275-286°C
Storage temp: -20°C Freezer
Appearance: White solid

 

 

Usage:
Leukemia drug Dasatinib is an oral potent oncogenic kinase inhibitor, which can block signal of cancer cell replication acceleration , in May 2009, the US Food and Drug Administration (FDA) formally approved the sale of dasatinib , It has been clinically used for the treatment of various chronic myeloid leukemia (CML), including treatment of chronic myeloid leukemia which is resistant or intolerant to the treating programs including imatinib mesylate., Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) and the treatment of patients with solid tumors.


October 28, 2010 ,the FDA approved dasatinib (Sprycel) of the new indication which is used for the treatment of the rare leukemia first diagnosed Philadelphia chromosome-positive called chronic myeloid leukemia (Ph + CP-CML) . The disease is a blood and bone marrow disease associated with genetic abnormality .


An open-label randomized clinical trial conducted in patients with CP-CML evaluated the safety and efficacy of dasatinib . Common side effects include decreased activity of the bone marrow caused by red blood cells, white blood cells and platelets decreased (myelosuppression), fluid retention, diarrhea, headache, musculoskeletal pain, and rash.


October 11, 2011, the US Food and Drug Administration (FDA) said the leukemia drug dasatinib (Sprycel, Bristol-Myers Squibb Company) might increase pulmonary arterial hypertension (PAH) risk. Pulmonary hypertension is a rare but serious disease that can lead to the condition that heart pumping blood to the lungs becomes more difficult by raising the pressure . PAH symptoms include shortness of breath, fatigue, swelling of the legs and ankles, clinicians must differentiate these symptoms from other similar symptoms.


Since 2006 Dasatinib was approved in the US market ,there had been 12 associated pulmonary hypertension events ,pulmonary hypertension symptoms included shortness of breath, fatigue, hypoxia and fluid retention, patients then were confirmed pulmonary hypertension by the results of right heart catheterization ,studies have shown that the biggest cause of the disease may come from patients taking dasatinib.

 

 

Uses:


1. Suitable for treatment of chronic myeloid leukemia which is resistant or intolerant to the treating programs including imatinib mesylate.
 

2. A new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic
 

3. Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
 

4. Directly targets wild-type and mutant c-Abl kinase domains

 

Anti-cancer Drug Raw Powder Dasatinib CAS: 302962-49-8 High Purity Pharmaceutical Raw Material 0

 

Price:
Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference.

 


Payment methods:
Wire Transfer, Western Union,
We will supply the receiver's information or the bank account information for payment use.

 


Shipping items:
Shipping items will be delivered by international express like EMS, TNT, UPS, FEDEX or DHL after receiving received.
Every item will be shipped out in 2-3 working days after the payment is done.
The product usually arrives in 4-10 days based on the different destination, and online track is provided.
Please kindly supply the company name, shipping address, contact and tel number for successful shipment.

 


Mix Order and Drop Shipping:
Mix order service and drop shipping service are available with us. You can choice several items of our products and request us send them in one mixed order.
Regarding drop shipping, we can arrange delivery according your request and do not supply any of our factory information for your safety sales network.

 


Storage:
Keep away from fire and heat source, hermetically deposit, keep in shady, cool and dry condition, protect against the tide.

 


Feedback:
We strive on make our customer satisfaction. Once received the products, please kindly give us a feedback so we can keep improving our products and service.
Should you have any problem, please let us know so we can work out with our joint efforts.

 

Packaging & Delivery:

Packaging Details Aluminium foil bag, bottle or fiber can
1g, 10g, 100g, 1 kg, 10 kg, 25 kg or as your requirement
Delivery Time Within 3 days after receive payment

Contact Details
Sales Manager

WhatsApp : +8613657291547