Pharmaceutical Raw Materials Steroids Hair Growth Minoxidil CAS 38304-91-5 For Hair Loss Treatment

Description:

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.

Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women. Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in both males and females with androgenic alopecia.About 40% of men experience hair regrowth after 3-6 months.Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth.It is the only topical product that is FDA-approved for androgenic hair loss.Treatments usually include a 5% concentration solution that is designed for men, and a 2% concentration solution for women.Minoxidil has been approved for female use by the FDA.

Minoxidil was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with side effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure. Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp. Minoxidil is a potassium channel agonist. It contains the chemical structure of nitric oxide), a blood vessel dilator, and may be a nitric oxide agonist. This appears to explain its vasodilatory effects, but may also be linked to minoxidil’s ability to stimulate hair growth and treat hair loss. Since minoxidil is a nitric oxide-related compound, it was suspected to act via activation of guanylate cyclase, an enzyme involved in vasodilation.

Application:

Minoxidil is an antihypertensive drug and a hair growth stimulant Vasodilator; treatment of hypertension; male pattern baldness. Minoxidil is used to lower blood pressure orally . If an external high doses , Minoxidil will be absorbed into the body through the skin , may cause headache, hypotension. If you accidentally dropped his face , may cause the drop of the Department overgrown hairs .

Minoxidil belongs to a class of drugs known as vasodilators. It is not known how minoxidil causes hair growth. This medication is not used for sudden/patchy hair loss, unexplained hair loss (e.g., no family history of hair loss), or hair loss after giving birth.

Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in both men and women with androgenic alopecia. About 40% of men experience hair regrowth after 3–6 months. Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth.Minoxidil solution and foam are used to help hair growth in the treatment of male pattern baldness. It is not used for baldness at the front of the scalp or receding hairline in men. The foam and 2 percent minoxidil solution is also used to help hair growth in women with thinning hair.

Minoxidil is a peripheral vasodilator that stimulates hair growth in male pattern alopecia and alopecia areata patients when used locally for a long period of time. Minoxidil can directly relax the vascular smooth muscle, a powerful small artery dilatation, so that peripheral resistance decreased blood pressure, and no effect on the volume of blood vessels, it can promote venous return. At the same time, due to the role of reflex regulation and positive frequency, cardiac output and heart rate can be increased, but does not cause orthostatic hypotension.

COA:

Function:

1. Minoxidil needs to be applied once or twice daily for hair to be maintained.

2. For maximum effect, the solution should be in contact with the scalp for hours before being washed out. It does not seem capable of reducing DHT or the enzyme responsible for its accumulation around the hair follicle, 5-aliha reductase, which are the main causes of male pattern baldness in genetically susceptible individuals. Therefore, when treatment is stopped, the DHT already accumlated around the follicle has its expected effect, and the follicle usually shrinks again and eventually dies.

3. Minoxidil solution are sold under many brand names. Many high price and generic brands of minoxidil regrowth solution exist and do not differ in their active ingredient or concentration.

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