Top Quality Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone CAS 53179-13-8 for Anti-Fibrosis Drug

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 53179-13-8
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
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Supply Ability: 3000KG/Month
Product Name: Pirfenidone CAS: 53179-13-8
MF: C12H11NO MW: 185.22
Mp: 96-97°C Appearance: Off-White Solid
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Product Name: Pirfenidone

Product details:
 
Product Name: Pirfenidone
Synonyms: amr-69
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
mp: 96-97°C
storage temp: Store at RT
solubility DMSO: ≥10 mg/mL, soluble
appearance: Off-White Solid

 

 

Description:


In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.

Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

 

 

Application:


pirfenidone is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo.Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

 

Top Quality Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone CAS 53179-13-8 for Anti-Fibrosis Drug 0

 

 

COA:

 

Product name Pirfenidone
batch No. 1407101 CAS No.

53179-13-8

Quantity 2 kg Manufacture Date 2018.3.26
Report Date 2018.04.09 Expiry Date 2018.05
Based on test Factory standard
Result of Analysis
Items Specifications Results
Appearance White or almost white crystalline powder Meets the requirements
Identification Meets the requirements Meets the requirements
Melting point 106ºC-108ºC 107.3ºC-108ºC
Water (K.F) Not more than 0.5% 0.09%
2-hydroxy-5-picoline Not more than 0.15% None
Any other unspecified Not more than 0.1% 0.03%
Total impurity Not more than 0.5% 0.05%
Bromobenzene Not more than 0.036% 0.01%
Ethyl acetate Not more than 0.5% None
Heavy metal Not more than 20ppm Less than 20ppm
R0l Not more than 0.1% Less than 0.1%
Assay Not less than 98.0% 99.5%
Conclusion

Comply with the requirements.

 

 

 

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