99% Top Quality Pharmaceutical Raw Estrogen Steroid Powder Pregnenolone CAS: 145-13-1

Product Name: Pregnenolone

Product detils:

Product Name: Pregnenolone
Synonyms: 3-beta-Hydroxypregn-5-en-20-one; Pregnenolone; Arthenolone;
CAS: 145-13-1
Formula: C21H32O2
Molecular Weight: 316.48
EINECS: 205-647-4
Assay: 99%
Appearance: Pregnenolone is a white to off-white powder
Package: 25kg/drum
Density: 1.09 g/cm3
Melting Point: 188-190 ° C
Boiling Point: 443.3 ° C at 760 mmHg
Flash Point: 188.9 ° C
Solubility: Pregnenolone is Insoluble in water
Usage: Pregnenolone contains ketones and hydroxyl functional groups, two methybranches, and a double bond at C5
Storage: Pregnenolone should be stored in cool, dry and ventilated places, kept far from fire.

Description:

Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning. Pregnenolone is also being considered as a potential treatment for schizophrenia. Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the GABAA receptor as well as a positive allosteric modulator of the NMDA receptor. In addition, it has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release.

Pregnenolone is a chemical that is found in our bodies. It can also be made in a laboratory. People use it for medicine. Pregnenolone is used for fatigue and increasing energy; Alzheimer's disease and enhancing memory; trauma and injuries; as well as stress and improving immunity. It is also is used for skin disorders including psoriasis and scleroderma. Women use pregnenolone for lumpy breasts (fibrocystic breast disease), a disorder of the lining of the uterus (endometriosis), symptoms of menopause, and premenstrual syndrome (PMS). Some people use pregnenolone for slowing or reversing aging, arthritis, and depression. It is also used for strengthening the heart, allergic reactions, "detoxification," lupus, multiple sclerosis (MS), prostate problems, and seizures. Because the body uses pregnenolone to make many hormones, pregnenolone was studied for stress, fatigue, and arthritis in the 1940s before lab-made hormones became available.

Pregnenolone is a natural hormone that cannot be patented. Back in the 1940's, when researchers started experimenting with it, they realized that it could be helpful for people under stress and it could increase energy in those who were fatigued. However, about the same time, cortisol, another closely related hormone, was discovered. Cortisol stole the limelight. When cortisol was given to individuals with rheumatoid arthritis, there were outstanding short-term improvements. Photographs of these remarkable recoveries were circulated and the medical community was impressed. Scientists basically put pregnenolone aside to focus on cortisol. The structure of cortisol was altered to make similar molecules such as dexamethasone and prednisone, much more powerful steroids. Dexamethasone and other similar corticosteroids could be patented, and thus a pharmaceutical company could make a lot of money. Pregnenolone has stayed in relative obscurity since the 1940's, with only rare mentions in the medical literature. There have been few studies published on pregnenolone in recent years, and only a couple involve human subjects.

Application:

1. Used in the synthesis of steroid drug intermediate and steroid drugs;
2. Used as intermediate for the synthesis of progesterone, antiflamison;
3. With the same function of corticosteroids anti-inflammatory.
Pregnenolone is used for fatigue and increasing energy; Alzheimer's disease and enhancing memory; trauma and injuries; as well as stress and improving immunity.
It is also is used for skin disorders including psoriasis and scleroderma. Women use pregnenolone for lumpy breasts (fibrocystic breast disease), a disorder of the lining of the uterus (endometriosis), symptoms of menopause, andpremenstrual syndrome (PMS). Some people use pregnenolone for slowing or reversing aging, arthritis, anddepression. It is also used for strengthening the heart, allergic reactions, "detoxification," lupus, multiple sclerosis (MS), prostate problems, and seizures.

COA:

Our Company Advantages:

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.