99% Purity Donepezil Powder for Alzheimer's Disease CAS: 120014-06-4 Pharmaceutical Grade

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 120014-06-4
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Work Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Donepezil CAS: 120014-06-4
MF: C24H29NO3 MW: 379.49
EINECS: 1312995-182-4 Melting Point: 207°C
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Basic Information:
Product Name: Donepezil
Synonyms: 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;AKOS 226-23;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;n-1-one;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one
CAS: 120014-06-4
MF: C24H29NO3
MW: 379.49
EINECS: 1312995-182-4
Melting point: 207°C
Water Solubility: 2.931 mg/L

Definition ChEBI:
Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.



Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.



Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main

therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects

include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses

the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be

taken once a day.


Donepezil has been tested in other cognitive disorders (and is sometimes used off label)

including Lewy body dementia and vascular dementia, but it is not currently approved for

these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients.

Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia,

attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment

associated with multiple sclerosis, CADASIL, and Down syndrome.


A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was

superior to placebo in delaying rate of progression to dementia during the initial 18

months of the study but this was not sustained at 36 months. In a secondary analysis, a

subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with

donepezil throughout the study. However at this time donepezil is not indicated for

prevention of dementia. Recent studies suggest that Donepezil can improve speech in

children with autism. The studies found that speech of autistic children who were mild to

moderately affected appeared to improve from the use of Donepezil.


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