99% High Quality Sarms Steroid Powder Aicar Acadesine CAS 2627-69-2 for Bodybuilding

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 2627-69-2
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
Product Name: AICAR CAS: 2627-69-2
MF: C9H14N4O5 MW: 258.23
EINECS: 220-097-5 Appearance: Tan Powder
High Light:

pharmaceutical anabolic steroids

,

pharmaceutical fine chemicals

Product Name: AICAR 

Product details:

Product description
Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

 

Description:

 

AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects. Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.

 

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulins-independent glucose uptake by skeletal muscle. Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.

 

 

COA:

 


Item

Specification

Result

Appearance


White powder

Complies

Related substance (HPLC)

Total impurity ≤0.5%
Max single impurity ≤0.1%

0.2%
0.06%

Odor

Characteristic

Complies

Assay

99%

99.8%

Sieve analysis

100% pass 80 mesh

Complies

Loss on Drying
Residue on Ignition

≤1.0%
≤1.0%

0.12%
0.09%

Heavy Metal

<10ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

Residual Solvents

<100ppm

Complies

Residual Pesticide

Negative

Complies

Microbiology
   

Total Plate Count

<1000cfu/g

Complies

Yeast & Mold

<100cfu/g

Complies

E.Coli

Negative

Complies

Salmonella

Negative

Complies

 

 

Application:

 

 

Sarms AICAR/ Acadesine powder help burn fat and sustain output in activity
AICAR is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in.

Aicar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/ inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

99% High Quality Sarms Steroid Powder Aicar Acadesine CAS 2627-69-2 for Bodybuilding 0

 

 

Function:


AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

 

 

Our Company Advantages:

 

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

The Related Local Anesthetic Products:

 

Benzocaine CAS:94-09-7
Benzocaine hydrochloride CAS:23239-88-5
Tetracaine hydrochloride CAS:136-47-0
Procaine CAS:59-46-1
Lidocaine CAS:137-58-6
Dibucaine hydrochloride CAS:61-12-1
Prilocaine CAS:721-50-6
Propitocaine hydrochloride CAS:1786-81-8
Proparacaine hydrochloride CAS:5875-06-9
Lidocaine hydrochloride CAS:73-78-9
Articaine hydrochloride CAS:23964-57-0
Levobupivacaine hydrochloride CAS:27262-48-2
Ropivacaine hydrochloride CAS:132112-35-7
Bupivacaine CAS:2180-92-9
Bupivacaine hydrochloride CAS:14252-80-3
Tetracaine CAS:94-24-6
Pramoxine Hydrochloride CAS:637-58-1
Procaine HCl CAS:51-05-8
 

 

 

Our Other Products:

 

Testosterone Steroid    
No. CAS NO Name
1 CAS:58-22-0 Testosterone base
3 CAS:76-43-7 Fluoxymesterone Halotestin
4 CAS:2446-23-3 4-Chlorodehydromethyltestosterone(Oral turinabol)
5 CAS:1255-49-8 Testosterone Phenylpropionate
6 CAS:57-85-2 Testosterone Propionate
7 CAS:1045-69-8 Testosterone acetate
8 CAS:315-37-7 Testosterone enanthate
9 CAS:58-20-8 Testosterone Cypionate
10 CAS:1424-00-6 Mesterolone (Proviron)
11 CAS:5949-44-0 Testosterone Undecanoate
12 CAS:15262-86-9 Testosterone isocaproate
13 CAS:855-19-6 Turinabol(4-Chlorotestosterone/Clostebol Acetate)
14 CAS: NO Testosterone Sustanon 250/100
15 CAS:5721-91-5 Testosterone decanoate
16 CAS:58-18-4 Methyltestosterone (17-methyltestosterone)
17 CAS:58-20-8 1-Test Cyp,Dihydroboldenone Cypionate
Boldenone Steroid    
17 CAS:846-48-0 Boldenone
18 CAS:13103-34-9 Boldenone Undecylenate (Equipoise)
19 CAS:846-46-0 Boldenone Acetate
20 CAS:13103-34-9 Boldenone Propionate
21 CAS:106505-90-2 Boldenone Cypionate
Trenbolone Steroid    
22 CAS:10161-33-8 Trenbolone base
23 CAS:10161-34-9 Trenbolone acetate(Finaplix H/Revalor-H)
24 CAS:472-61-546 Trenbolone enanthate(parabolan)
25 CAS:23454-33-3 Trenbolone Hexahydrobenzyl Carbonate
Nandrolone Steroid    
26 CAS:434-22-0 Nandrolone
27 CAS:62-90-8 Nandrolone Phenypropionate (NPP)/durabolin
28 CAS: 601-63-8 Nandrolone cypionate
29 CAS:360-70-3 Nandrolone decanoate(DECA)/ Deca durabolin
30 CAS: 862-89-5 Nandrolone Undecylate
31 CAS: 7207-92-3 Nandrolone propionate
Primobolan Steroid    
32 CAS:434-05-9 Methenolone Acetate(Primobolan)
33 CAS:303-42-4 Methenolone enanthate (USAN)
34 CAS: 153-00-4 Metenolone
35 CAS:3381-88-2 Superdrol Powder/Methasterone (methyl-drostanolone)
36 CAS:521-12-0 Drostanolone Propionate (Masteron)
37 CAS:472-61-145 Drostanolone Enanthate(Masteron)
Anabolic Steroids    
38 CAS:72-63-9 Methandrostenolone (Dianabol, methandienone)
39 CAS:3704-09-4   Mibolerone
40 CAS:965-93-5 Methyltrienolone (Metribolone)
41 CAS:5197-58-0 Methylstenbolone
42 CAS: 5630-53-5 Tibolone
43 CAS:521-11-9 Mestanolone
44 CAS:521-18-6 Stanolone (androstanolone)
45 CAS:434-07-1 Oxymetholone (Anadrol)
46 CAS:53-39-4 Oxandrolone(Anavar)
47 CAS:10418-03-8 stanozolol(Winstrol)
48 CAS:6157-87-5 Trestolone acetate
49 CAS:853-23-6 Dehydroisoandrosterone 3-acetate
50 CAS:53-43-0 Dehydroepiandrosterone (DHEA)
51 CAS:481-29-8 Epiandrosterone
52 CAS:566-19-8 7-Keto-dehydroepiandrosterone
53 CAS:76822-24-7 1-DHEA

 

 

Other hot-selling steroids and peptides:

 

Testosterone Acetate Trenbolone Acetate MGF
Testosterone Cypionate Trenbolone Enanthate PEG MGF
Testosterone Decanoate Boldenone Acetate CJC-1295
Testosterone Enanthate Boldenone undecylenate CJC-1295 DAC
Testosterone Isocaproate Boldenone Cypionate PT-141
Testosterone Phenylpropionate Boldenone Propionate Melanotan-1
Testosterone Propionate Nandrolone Decanoate Melanotan-2
Testosterone Undecanoate Nandrolone phenylpropionate GHRP-2
Mesterone Nandrolone undecylate GHRP-6
Testosterone Sustanon 250 Nandrolone cypionate Ipamorelin
Clostebol Acetate Nandrolone propionate Hexarelin
Methylandrostanolone Methyltrienolone Sermorelin
Methenolone Enanthate Drostanolone Propionate Oxytocin
Methenolone Acetate Drostanolone Enanthate TB500
Anadrol Stanolone Fragment 176-191
Anavar Tadalafil Triptorelin
Winstrol Vardenafil Tesamorelin
Clomifene citrate Dianabol Gonadorelin
Toremifene citrate Tamoxifen Citrate DSIP
Finasteride hydrochloride Selank
Benzocaine Liothyronine sodium T3 L-Carnitine

 

 

Contact Details
Sales Manager

WhatsApp : +8613657291547