Anti Early Pregnancy Anabolic Steroid Hormones Female Contraception Levonorgestrel CAS 797-63-7

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 797-63-7
Minimum Order Quantity: 10g
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Supply Ability: 3000KG/Month
Product Name: Levonorgestrel CAS: 797-63-7
MF: C21H28O2 MW: 442.22
Assay: 312.45 Appearance: White Or Almost White Crystalline Powder
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Product Name: Levonorgestrel

 

Product Details:

 

Synonyms: 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one;13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one;13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1;17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one;17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one;17-ethynyl-18-methyl-19-nortestosteron;17-ethynyl-18-methyl-19-nortestosterone;18-methyl-17-alpha-ethynyl-19-nortestosterone
CAS: 797-63-7

Assay: 99%
Formula: C21H28O2
Molecular Weight: 312.45
EINECS: 212-349-8
Density: 1.13 g/cm3
Melting Point: 206 ° C
Boiling Point: 459.1 ° C at 760 mmHg
Flash Point: 95.4 ° C
Appearance: White or almost white crystalline powder
Application: Progesterone medicine
Storage: Stored and protected from light

Usage: Progesterone drug, used for irregular menstruation, functional uterine bleeding, endometriosis

 

 

Description:


Levonorgestrel (or l-norgestrel or D-norgestrel) is a second generation progestin (synthetic progestogen) used as an active ingredient in some hormonal contraceptives, including combined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems, contraceptive implants, and hormone replacement therapy. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system
Levonorgestrel is used in emergency contraceptive pills(ECPs), both in a combined Yuzpe regimenwhich includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5mg (as a single dose or as two 0.75mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective. Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors but not the estrogen receptor. Induces apoptosis in ovarian epithelium cells.

 

 

Application:

 

Oral contraception
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µ G, and triphasic doses of 50 µ G/75 µ G/125 µ G. At very low daily dose of 30 µ G, levonorgestrel is used in some progestogen only pill formulations.
Emergency contraception
Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5 mg (as a single dose or as two 0.75 mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.
Intrauterine system
Levonorgestrel is the active ingredient in the Mirena & Skyla (Jaydess) intrauterine system.
Contraceptive implants
Levonorgestrel is the active ingredient in Norplant and Jadelle.
Hormone replacement therapy
Levenorgestrel is combined with 17-beta estradiol in the Climara Pro hormonal patch.

Applied in pharmaceutical field, Levonorgestrel can be used as an active ingredient in some hormonal contraceptives, including combined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems and contraceptive implants; Levonorgestrel is safe, tolerated and effective in emergency contraception in woman; Levonorgestrel also can be used for the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.

Oral contraceptives, levonorgestrel, also known as D- norethindrone, left Kanok ketone, is currently the most widely used oral contraceptives, the racemic optically active part of norethindrone, the activity ratio norethindrone strong double dose can be reduced by half, adverse reactions are also reduced accordingly. Rapid oral absorption, 0.5 ~ 1h, reached the peak. t1 / 2 of 10 ~ 24h.Protein binding rate of 93% to 95%, bioavailability, mainly located in the liver, kidney, ovarian and uterine body's organs and tissues, and its metabolites, mainly in the form of glucuronide and sulfate salts from the urine and feces in vitro. And ethinyl estradiol combination as a short-acting oral contraceptives. Its dual photo and three photo adverse reactions less, closer to women's normal hormone secretion type. Women can be used for emergency contraception, namely failure (condom slippage or breakage, coitus out of control, rhythm miscalculation, etc.) in the same room of post-coital contraception measures unprotected intercourse or other contraceptive methods.

 

 

COA:

 

Items
Specification

Results

Description

White or practically white crystalline powder

White crystalline powder

Specific Rotation

30°~-35°

32°

Melting Range

232~239°C, and melting range is not more then 4°C

234~238°C

identification

It complies with the test for specific optical rotation and melting point

Conforms
 
Infrared absorption spectrophotometry should be consistent with levonorgestrel CRS

Conforms

Loss on drying

≤0.5%

0.20%

Residue on ignition

≤0.3%

0.07%

Limit of Ethynyl Group

7.81%~8.18%

7.92%

Related substances

Single impurity ≤0.5%

single impurity<0.5%
 
Total Impurities ≤2.0%

Total impurities<2.0%

Organic Volatile impurties

Ethanol ≤5000ppm

1200ppm
Assay The product complies with specification in USP34

 

 

Anti Early Pregnancy Anabolic Steroid Hormones Female Contraception Levonorgestrel CAS 797-63-7 0

 

 

Dosage:

 

At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µ G, and triphasic doses of 50 µ G/75 µ G/125 µ G. At very low daily dose of 30 µ G, levonorgestrel is used in some progestogen only pill formulations.
As the three weekly photo of reducing the product with about 40%, so the fewer adverse reactions. Levonorgestrel such as changes in dosage form can also be used a variety of long-acting contraceptives. Used as a short-acting oral contraceptives: from the first five days of menstruation to start taking the compound levonorgestrel tablets, a day, even for 22 days, without interruption, at bedtime. So the next menstruation after serving five days to continue the medication. May have nausea, vomiting, headache, breast swelling after serving, acne, weight gain, depression, lowered HDL, breakthrough bleeding, amenorrhea. Liver and kidney dysfunction, breast masses were hanged. Uterine fibroids, hypertension and liver and kidney disease history of caution. Not as a regular birth control pills, to be taken next reliable contraceptive measures premenstrual medication. Women who smoke should not take (due to complicated by cardiovascular disease).

 

 

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