Place of Origin: | CHINA |
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Brand Name: | TINGYI |
Certification: | GMP , ISO 9001:2008 |
Model Number: | CAS: 25122-46-7 |
Minimum Order Quantity: | 10g |
Price: | Contact Us |
Packaging Details: | Stealth and discreet packaging |
Delivery Time: | Usually within 7 work days |
Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
Supply Ability: | 3000KG/Month |
Product Name: | Clobetasol Propionate | Synonyms: | Clobetasol-17-Propionate;Clobetasol Propionate |
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CAS: | 25122-46-7 | Molecular Formula: | C25H32ClFO5 |
Molecular Weight: | 466.97 | Appearance: | White Crystalline Powder |
High Light: | pharmaceutical active ingredients,pharmaceutical anabolic steroids |
Product Name: Clobetasol propionate
Product Details:
Name |
Clobetasol propionate |
Synonyms |
Clobetasol-17-Propionate;Clobetasol propionate |
Type of medicine |
A very potent topical corticosteroid |
CAS |
25122-46-7 |
Molecular formula |
C25H32ClFO5 |
Molecular Weight
|
466.97 |
Description |
Topical corticosteroid, Glucocorticoid, anti-inflammatory |
Content |
99.4% |
Standard Level |
USP30 |
Melting point |
about 196 ° C |
Specific rotation |
+98 - + 104 ° C |
Density |
1.28g/cm3 |
Boiling point |
569 degrees C at 760 mmHg |
Flash |
297.9 degrees C |
steam pressure |
25 ~ C 2.58E-15mmHg at 25℃ |
Used |
Inflammatory skin conditions such as severe eczema and dermatitis |
Appearance |
white crystalline powder |
Usage |
Adrenal cortical hormone and adrenal cortical hormone |
Storage conditions |
8 - 2 degrees C, to avoid light and moisture sealed dry. |
Description:
Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema anddermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Clobetasol propionate relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms.
Specialist skin doctors may on occasion prescribe a short course of clobetasol propionate for the treatment of psoriasis, although it is not generally recommended for this skin condition. Clobetasol propionate is not recommended for use in children, although again, it may be prescribed for a child by a specialist doctor under certain circumstances. Clobetasol propionate is available as a number of different preparations. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, or an ointment if your skin is dry. It is also available as a shampoo and as an application for the scalp.There is also a preparation available which contains two antibacterial agents called neomycin and nystatin. You may be prescribed this preparation for short-term use if your skin has become infected. It is typically used twice a day for one week only. Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison IVY/oak.
Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.
Application:
1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.
2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins
Chloropropionic acid times his claim for the artificial synthesis of high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary contraction, 2.3 times of betamethasone sodium phosphate, fluoride relaxed 18.7 times. At the same time with the inhibition of cell mitosis, can effectively penetrate into skin cutin layer.
Chronic eczema and neurodermatitis local application, psoriasis, palmoplantar pustulosis, lichen planus,discoid lupus erythematosus, glucocorticoid, topical therapy is effective for non infectious inflammatory dermatosis pruritus.
Anti inflammation, anti allergy, anti proliferation, immune suppression.
Can product: compound ketoconazole. Miconazole nitrate, vitamin A acid cream and liniment.
Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.
Clobetasol proprionate is used cosmetically by dark-skinned women for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, it is often sold in U.S. retail beauty supply stores and on the internet. It is also sold internationally, and does not require a prescription in some countries. Whitening creams with clobetasol proprionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body’s natural steroids, and stretch marks, which may be permanent.
COA:
Standard adopted | USP38 | |
Items of analysis | Specification | Results |
Description | White or almost white crystalline powder | Almost white crystalline powder |
Solubility | Practically insoluble in water, slightly soluble in benzene and diethyl ether, sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane | Complies |
Identification (IR) | Complies with the Standard | Complies |
Specific Rotation | +98°~+104° | +100.4° |
Melting point | About 196ºC | 195.0ºC~197.0ºC |
Loss on drying | Max. 2.0% | 0.20% |
Residue on ignition | Max. 0.1% | 0.04% |
Heavy Metals | Max. 20ppm | Complies |
Single impurity | N. M. T 1.0% | 0.16% |
Sum impurity | N. M. T 2.5% | 0.46% |
Organic volatile impurities | Meet the ICH requirement | Complies |
Assay(HPLC, basisondrying) | 98.5%~102.0% | 99.9% |
THF | Not more than 720ppm | Complies |
Methanol | Not more than 3000ppm | Complies |
DMF | Not more than 880ppm | Complies |
Pyridine | Not more than 200ppm | Complies |
Dichloromethane | Not more than 600ppm | Complies |
Ethanol | Not more than 5000ppm | Complies |
Acetone | Not more than 5000ppm | Complies |
Our Company Advantages:
1, High quality with competitive price:
1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
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