CAS 25122-46-7 Pharmaceutical Raw Materials Clobetasol Propionate For Anti - Inflammatory

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 25122-46-7
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
Product Name: Clobetasol Propionate Synonyms: Clobetasol-17-Propionate;Clobetasol Propionate
CAS: 25122-46-7 Molecular Formula: C25H32ClFO5
Molecular Weight: 466.97 Appearance: White Crystalline Powder
High Light:

pharmaceutical active ingredients

,

pharmaceutical anabolic steroids

Product Name: Clobetasol propionate

 

Product Details:

 

Name  

Clobetasol propionate

Synonyms  

Clobetasol-17-Propionate;Clobetasol propionate

Type of medicine  

A very potent topical corticosteroid

CAS  

25122-46-7

Molecular formula  

C25H32ClFO5

Molecular Weight
 

466.97

Description  

Topical corticosteroid, Glucocorticoid, anti-inflammatory

Content  

99.4%

Standard Level  

USP30

Melting point  

about 196 ° C

Specific rotation  

+98 - + 104 ° C

Density  

1.28g/cm3

Boiling point  

569 degrees C at 760 mmHg

Flash  

297.9 degrees C

steam pressure  

25 ~ C 2.58E-15mmHg at 25℃

Used  

Inflammatory skin conditions such as severe eczema and dermatitis

Appearance  

white crystalline powder

Usage  

Adrenal cortical hormone and adrenal cortical hormone

Storage conditions  

8 - 2 degrees C, to avoid light and moisture sealed dry.

 

 

Description:

 

Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema anddermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Clobetasol propionate relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms.

Specialist skin doctors may on occasion prescribe a short course of clobetasol propionate for the treatment of psoriasis, although it is not generally recommended for this skin condition. Clobetasol propionate is not recommended for use in children, although again, it may be prescribed for a child by a specialist doctor under certain circumstances. Clobetasol propionate is available as a number of different preparations. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, or an ointment if your skin is dry. It is also available as a shampoo and as an application for the scalp.There is also a preparation available which contains two antibacterial agents called neomycin and nystatin. You may be prescribed this preparation for short-term use if your skin has become infected. It is typically used twice a day for one week only. Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison IVY/oak.

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.

 

 

Application:

 

1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.
2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins

Chloropropionic acid times his claim for the artificial synthesis of high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary contraction, 2.3 times of betamethasone sodium phosphate, fluoride relaxed 18.7 times. At the same time with the inhibition of cell mitosis, can effectively penetrate into skin cutin layer.
Chronic eczema and neurodermatitis local application, psoriasis, palmoplantar pustulosis, lichen planus,discoid lupus erythematosus, glucocorticoid, topical therapy is effective for non infectious inflammatory dermatosis pruritus.
Anti inflammation, anti allergy, anti proliferation, immune suppression.
Can product: compound ketoconazole. Miconazole nitrate, vitamin A acid cream and liniment.
Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.
Clobetasol proprionate is used cosmetically by dark-skinned women for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, it is often sold in U.S. retail beauty supply stores and on the internet. It is also sold internationally, and does not require a prescription in some countries. Whitening creams with clobetasol proprionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body’s natural steroids, and stretch marks, which may be permanent.

 

CAS 25122-46-7 Pharmaceutical Raw Materials Clobetasol Propionate For Anti - Inflammatory 0

 

 

COA:

 

Standard adopted USP38
Items of analysis Specification Results
Description White or almost white crystalline powder Almost white crystalline powder
Solubility Practically insoluble in water, slightly soluble in benzene and diethyl ether, sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane Complies
Identification (IR) Complies with the Standard Complies
Specific Rotation +98°~+104° +100.4°
Melting point About 196ºC 195.0ºC~197.0ºC
Loss on drying Max. 2.0% 0.20%
Residue on ignition Max. 0.1% 0.04%
Heavy Metals Max. 20ppm Complies
Single impurity N. M. T 1.0% 0.16%
Sum impurity N. M. T 2.5% 0.46%
Organic volatile impurities Meet the ICH requirement Complies
Assay(HPLC, basisondrying) 98.5%~102.0% 99.9%
THF Not more than 720ppm Complies
Methanol Not more than 3000ppm Complies
DMF Not more than 880ppm Complies
Pyridine Not more than 200ppm Complies
Dichloromethane Not more than 600ppm Complies
Ethanol Not more than 5000ppm Complies
Acetone Not more than 5000ppm Complies
 

 

 

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