CAS 67392-87-4 Pharmaceutical Raw Materials Drospirenone For Contraception

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 67392-87-4
Minimum Order Quantity: 10g
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Supply Ability: 3000KG/Month
Product Name: Drospirenone CAS: 67392-87-4
MF: C24H30O3 MW: 366.49
Assay: 99.50% Appearance: White Crystalline Powder
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Product Name: Drospirenone

 

Product Details:

 

Product Name Drospirenone
Alias arbolactone
CAS 67392-87-4
MF C24H30O3
MW 366.49
EINECS 266-679-2
Melting point 196-200ºC
Boiling point 552.2±50.0 °C at 760 mmHg
Flash point 241.6±30.2 °C
Purity 99.50%
Grade Pharmaceutical Grade
Appearance white Crystalline Powder
Standard USP
Stock Mass Stock
Shelf Life 2years
Usage Drospirenone is the progesterone hormone.
Drospirenone is an ingredient in some birth control pills.

 

 

 

Descriptions:

 

Drospirenone (INN, USAN), also known as 1,2-dihydrospirorenone, is a synthetic hormone used in birth control pills and postmenopausal hormone replacement therapy pills.It is sold under the brand names Yasmin, Yasminelle, Yaz, Beyaz, Ocella, Zarah, Daylette and Angeliq, all of which arecombination products of drospirenone with an estrogen such as ethinylestradiol or estradiol. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has potent antimineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and has also been shown to possess mild antiandrogen activity.The antimineralocorticoid properties exhibited by drospirenone promote sodium excretion and prevent water retention.

 

It is a new synthetic progestin with anti mineralocorticoid activity. Its pharmacological properties are similar to that of endogenous progesterone. It can form an effective, safe and short acting contraceptive pill with estradiol and estradiol.  Drospirenone is an ingredient in some birth control pills and hormone replacement therapy. In combination with ethinyl estradiolit is used as contraception, and for women who want contraception it is also approved by the U. S. Food and Drug Administration(FDA) to treat moderate acne and premenstrual dysphoric disorder.

Drospirenone is the only progesterone that has the characteristics similar to the natural progesterone currently, its structure is more like that of the natural progesterone compare with the structure of the progesterone contained in the traditional oral contraceptives.Except the effect of anti-androgen, drospirenone has the role of anti-mineralocorticoid which can prevent water and sodium retain in the body. Not only it has the a great effectivenes of contraception, there are also many good impacts on women's health like reducing the acne, making the skin more smooth and controling the weight efficaciously.

 

Drospirenone is an aldosterone antagonist with potassium-sparing properties, though in most cases no increase of potassium levels is to be expected. In women with mild or moderate renal insufficiency, or in combination with chronic daily use of other potassium-sparing medications (ACE inhibitors, angiotensin II receptor antagonists, potassium-sparing diuretics, heparin, aldosterone antagonists, or NSAIDs), a potassium level should be checked after two weeks of use to test for hyperkalemia.

 

 

Applications:

 

Flexor screw ketone (Drospirenone) is a kind of resistance mineralocorticoid activity of new synthetic progesterone, its pharmacological properties similar to endogenous progestin, with ethinylestradiol constitute a kind of high efficiency, good safety and high degree of acceptance of a short-acting contraceptives.

 

Drospirenone is an ingredient in some birth control pills and hormone replacement therapy. In combination with ethinyl estradiolit is used as contraception, and for women who want contraception it is also approved by the U. S. Food and Drug Administration(FDA) to treat moderate acne and premenstrual dysphoric disorder. Drospirenone and ethinyl estradiol combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

Drospirenone and ethinyl estradiol combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

Drospirenone is 8–10 times more potent as an antimineralocorticoid relative to spironolactone (3 mg drospirenone is equivalent to about 20–25 mg spironolactone in this regard. It is more potent as an antiandrogen relative to spironolactone also but is less potent relative to cyproterone acetate, having about one-third the potency of this drug. Progestogenic, antimineralocorticoid, and mild antiandrogenic effects have been observed in humans during treatment with drospirenone at a dosage range of 0.5 to 4 mg per day orally. The antimineralocorticoid properties exhibited by drospirenone promote sodium excretion and prevent water retention.

Drospirenone (INN, USAN), also known as 1,2-dihydrospirorenone, is a synthetic hormone used in birth control pills and postmenopausal hormone replacement therapy pills. all of which are combination products of drospirenone with an estrogen such as ethinylestradiol or estradiol.

 

CAS 67392-87-4 Pharmaceutical Raw Materials Drospirenone For Contraception 0

 
 
COA:
 

TEST ITEMS

SPECIFICATION

RESULTS

Description

White or Almost White Crystalline Powder

white powder

Identification

A.B.

Positive

Assay

97.0~103.0%

99.3%

Specific Rotation

+101°~+105°

+102.6°

Loss On Drying

1.0%max

0.27%

Melting Point

153~157°C

153.0~155.0°C

Organic Volatile Impurities

meets the requirement.

Conforms

Related Substances

meets the requirement.

Conforms

Residual Solvents

meets the requirement.

Conforms

Particle Size

100% ≤ 20 microns

Conforms

Conclusion

The specification conform with USP30 standard

 

 

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1, High quality with competitive price:

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2) All Purity≥99.8%
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Product List of female hormone:
 

Product List of female hormone

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CAS:2446-23-3

4-Chlorodehydromethyltestosterone(Oral turinabol)

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CAS:1255-49-8

Testosterone Phenylpropionate

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CAS:57-85-2

Testosterone Propionate

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Testosterone acetate

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Testosterone enanthate

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Testosterone Cypionate

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CAS:1424-00-6

Mesterolone (Proviron)

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CAS:5949-44-0

Testosterone Undecanoate

12

CAS:15262-86-9

Testosterone isocaproate

13

CAS:855-19-6

Turinabol(4-Chlorotestosterone/Clostebol Acetate)

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CAS: NO

Testosterone Sustanon 250/100

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Testosterone decanoate

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CAS:58-18-4

Methyltestosterone (17-methyltestosterone)

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CAS:58-20-8

1-Test Cyp,Dihydroboldenone Cypionate

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17

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Boldenone

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CAS:13103-34-9

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19

CAS:846-46-0

Boldenone Acetate

20

CAS:13103-34-9

Boldenone Propionate

21

CAS:106505-90-2

Boldenone Cypionate

Trenbolone Steroid

 

 

22

CAS:10161-33-8

Trenbolone base

23

CAS:10161-34-9

Trenbolone acetate(Finaplix H/Revalor-H)

24

CAS:472-61-546

Trenbolone enanthate(parabolan)

25

CAS:23454-33-3

Trenbolone Hexahydrobenzyl Carbonate

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26

CAS:434-22-0

Nandrolone

27

CAS:62-90-8

Nandrolone Phenypropionate (NPP)/durabolin

28

CAS: 601-63-8

Nandrolone cypionate

29

CAS:360-70-3

Nandrolone decanoate(DECA)/ Deca durabolin

30

CAS: 862-89-5

Nandrolone Undecylate

31

CAS: 7207-92-3

Nandrolone propionate

Primobolan Steroid

 

 

32

CAS:434-05-9

Methenolone Acetate(Primobolan)

33

CAS:303-42-4

Methenolone enanthate (USAN)

34

CAS: 153-00-4

Metenolone

35

CAS:3381-88-2

Superdrol Powder/Methasterone (methyl-drostanolone)

36

CAS:521-12-0

Drostanolone Propionate (Masteron)

37

CAS:472-61-145

Drostanolone Enanthate(Masteron)

Anabolic Steroids

 

 

38

CAS:72-63-9

Methandrostenolone (Dianabol, methandienone)

39

CAS:3704-09-4  

Mibolerone

40

CAS:965-93-5

Methyltrienolone (Metribolone)

41

CAS:5197-58-0

Methylstenbolone

42

CAS: 5630-53-5

Tibolone

43

CAS:521-11-9

Mestanolone

44

CAS:521-18-6

Stanolone (androstanolone)

45

CAS:434-07-1

Oxymetholone (Anadrol)

46

CAS:53-39-4

Oxandrolone(Anavar)

47

CAS:10418-03-8

stanozolol(Winstrol)

48

CAS:6157-87-5

Trestolone acetate

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CAS:853-23-6

Dehydroisoandrosterone 3-acetate

50

CAS:53-43-0

Dehydroepiandrosterone (DHEA)

51

CAS:481-29-8

Epiandrosterone

52

CAS:566-19-8

7-Keto-dehydroepiandrosterone

53

CAS:76822-24-7

1-DHEA

 

 

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