White Powder Nootropics Active Pharmaceutical Ingredients Donepezil CAS 120014-06-4 For Brain Growth

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 62613-82-5
Minimum Order Quantity: 10g
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Supply Ability: 3000KG/Month
Product Name: Oxiracetam CAS: 62613-82-5
MF: C6H10N2O3 MW: 158.16
Assay: 99% Appearance: White Solid
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99% Nootropics White Powder for Alzheimer′s Disease Donepezil CAS 120014-06-4 for Brain Growth

 

Product Name: Donepezil

 

Product Details:

 

 

Product name

 

Donepezil
Synonyms

2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;

1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;

AKOS 226-23;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;

n-1-one;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;

5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one

 

Assay

 

99%

 

CAS

 

120014-06-4

 

Packing

 

Customized package as you require

 

M.F.

 

C24H29NO3

 

M.W.

 

379.49

 

EINECS

 

1312995-182-4

 

Melting point

 

207°C

 

Appearance

 

White crystalline powder

 

Quality Standard

 

Enterprise Standard

 

Usage

 

Treatment of depression.

 

 

Description:

 

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

 

 

Application:

 

Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.

 

Donepezil binds and inactivates reversibly the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses. The precise mechanism of action of donepezil in patients with Alzheimer's disease is not fully understood. Certainly Alzheimer's disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer's disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain. It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.

 

 

White Powder Nootropics Active Pharmaceutical Ingredients Donepezil CAS 120014-06-4 For Brain Growth 0

 

COA:

 

 

 

TEST ITEM

 

SPECIFICATION RESULT

 

Appearance

 

Off white to white crystalline powder Complies

 

Solubility

 

freely Freely soluble in chloroform, soluble
in water and Acetic acid, slightly soluble in
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane
Complies
Identification (1)By IR absorption ,To match with working
standard
Complies
(2) The retention time of the major peak of
the sample should accord with that of the
working standard.
Complies
(3) Test for chlorides. Reponds to the test
for Chlorides.
Complies

 

PH

 

4.0-7.0 6.10

 

Residue on ignition

 

≤0.1% 0.03%

 

Related substance

 

Any Unkonwn single impurity≤0.3%
Total ≤0.5%
0.04%
0.18%

 

Heavy metal

 

≤10ppm <10ppm
Residual Solvents Methanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5%
Not detected
Not detected
Not detected
Not detected
Not detected

 

Loss on drying

 

≤0.5% 0.20%

 

Assay

 

On dried base, C24H29NO3·HCl
should be 98.0% to 102.0%
100.20%

 

Conclusion: The product complies to Enterprise standard

 

 

 

Dosage and Administration:

 

Allow Donepezil hydrochloride ODT to dissolve on the tongue and follow with water.

1) For Mild Moderate Alzheimer user:

Starting dosage: 5 mg administered once per day in the evening, just prior to retiring.

 

2) For mild to moderate Alzheimer user:

The maximum recommended dosage is 10 mg per day.

A dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 to 6 weeks.

 

 

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