High Quality Sedative Drug Xylazine Hydrochloride / Xylazine HCl CAS 23076-35-9 for Muscle Relaxant and Pain killer

Product Name: Xylazine Hydrochloride

Product Details:

Product Name: XYLAZINE HYDROCHLORIDE
Synonyms: 2-[2,6-DIMETHYLPHENYLAMINO]-4H-5,6-DIHYDROTHIAZINE HYDROCHLORIDE;2-[(2,6-DIMETHYLPHENYL)AMINO]-5,6-DIHYDRO-4H-1,3-THIAZINE HYDROCHLORIDE;2-(2,6-DIMETHYLPHENYLAMINO)-5,6-DIHYDRO-4H-THIAZINE HYDROCHLORIDE;(5,6-DIHYDRO-4H-[1,3]THIAZIN-2-YL)-(2,6-DIMETHYLPHENYL)-AMINE HCL;(5,6-DIHYDRO-4H-1,3-THIAZIN-2-YL)(2,6-DIMETHYLPHENYL)AMINE HYDROCHLORIDE;N-(2,6-DIMETHYLPHENYL)-5,6-DIHYDRO-4H-1,3-THIAZIN-2-AMINE HCL;XYLAZINE HCL;XYLAZINE HYDROCHLORIDE
CAS: 23076-35-9
MF: C12H17ClN2S
MW: 256.79
EINECS: 245-417-0
Chemical Properties: Off-White Solid

Usage: Xylazine HCl is α2 class of adrenergic receptor agonist. As with other α2 agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. It is a clonidine analoque. It acts on presynaptic and postsynaptic receptors of t
Usage: Xylazine is used as a sedative, analgesic, muscle relaxant.

Descriptions:

Xylazine hydrochloride, a non-narcotic compound, is a sedative and analgesic as well as a muscle relaxant. Its sedative and analgesic activity is related to central nervous system depression. Following intramuscular administration, the clinical effects of xylazine hydrochloride are apparent within 10-15 minutes. Clinical effects are observed within 3-5 minutes of intravenous administration. A sleeplike state, the depth of which is dose-dependent, is usually maintained for 1 to 2 hours, while analgesia lasts from 15 to 30 minutes.
Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.

In veterinary anesthesia, xylazine is often used in combination. It is sold under many brand names worldwide, most notably the Bayer brand name Rompun.It is also marketed as Anased, Sedazine, and Chanazine. The drug interactions vary with different animals.
Results from early human clinical studies confirmed that xylazine has several central nervous system depressant effects. Xylazine administration is used for sedation, anesthesia, muscle relaxation, and analgesia. It causes a significant reduction in blood pressure and heart rate in healthy volunteers

Application:

Xylazine is often used as a sedative, muscle relaxant, and analgesic.It is frequently used in the treatment of tetanus.Xylazine is very similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine.As an anesthetic, it is typically used in conjunction with ketamine.
Xylazine appears to reduce sensitivity to insulin and glucose uptake in humans.Yohimbine has been used to decrease glucose levels to a healthy level.In clinical settings, Yohimbine can reverse the adverse effects of xylazine if administered intravenously at a dosage of 0.5 mL / 20 pounds shortly after xylazine administration.
Xylazine is recognized as a short-acting tranquilizer or sedative that provides significant pain relief. Acting as a muscle relaxant through its effects on the central nervous system, it is commonly used for short-term sedation, and treatment and management of colic.

Dosage:

Xylazine can be administered intravenously, intramuscularly, subcutaneously or orally. The commercial product contains 23.32 mg/ml xylazine hydrochloride in water based injectable solution. Xylazine can be obtained also as pure crystalline powder. There is a significant species dependent response to xylazine administration. Intramuscular dose of up to 0.3 mg/kg for cattle has been suggested by the manufacturer. The recommended doses for horses were 0.6 mg/kg and for sheep 1.0 mg/kg. For dogs the dose was even higher.Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats.

Pharmacology:

(1)Xylazine HCl Injection (xylazine), a non-narcotic compound, is a sedative and analgesic as well as muscle relaxant. Its sedative and analgesic activity is related to central nervous system depression. Its muscle relaxant effect is based on inhibition of the intraneural transmission of impulses in the central nervous system. The principal pharmacological activities develop within 10 to 15 minutes after intramuscular injection in horses and Cervidae, and within 3 to 5 minutes following intravenous administration in horses.

(2)A sleeplike state, the depth of which is dose-dependent, is usually maintained for 1 to 2 hours, while analgesia lasts from 15 to 30 minutes. The centrally-acting muscle relaxant effect causes relaxation of the skeletal musculature, complementing sedation and analgesia.

(3)In horses and Cervidae under the influence of Xylazine HCl Injection (xylazine), the respiratory rate is reduced as in natural sleep. Following treatment with Xylazine HCl Injection (xylazine), the heart rate is decreased and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by a partial atrioventricular block. This resembles the atrioventricular block often observed in normal horses. Partial A-V block may occasionally occur following intramuscular injection of Xylazine HCl Injection (xylazine). When given intravenously in horses, the incidence of partial A-V block is higher. Intravenous administration causes a transient rise in blood pressure in horses, followed by a slight decrease.

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