| Place of Origin: | CHINA |
|---|---|
| Brand Name: | GSP |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | CAS: 443913-73-3 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Us |
| Packaging Details: | Stealth and discreet packaging |
| Delivery Time: | Usually within 7 work days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 3000KG/Month |
| Product Name: | Vandetanib | CAS: | 443913-73-3 |
|---|---|---|---|
| MF: | C9H7Cl2N5 | MW: | 256.09 |
| EINECS: | 281-901-8 | Appearance: | White To Cream Coloured Powder |
| High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
||
|
Product Name
|
Vandetanib |
|
Synonyms |
VANDETANIB;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-; Vandetanib for research; 4-(4-Bromo-2-fluoroanilino)-6-methoxy- 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;N-(4-Bromo-2-fluorophenyl) -6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; Zactima;ZD 6474;7-((4-aminocyclohexyl) methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine |
|
CAS
|
443913-73-3 |
|
Assay
|
98% |
|
MF
|
C22H24BrFN4O2 |
|
MW
|
475.35 |
|
Mol File
|
443913-73-3.mol |
|
Density
|
1.406 |
|
Appearance
|
Yellow Solid |
|
Usage |
Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC). |
|
Product Categories
|
Aromatics Compounds;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;ZD6474 |
Vandetanib is a kind of small molecule multi-targeted tyrosine kinase inhibitor studied and developed by the British AstraZeneca Company. In April 2011, it was approved the US FDA for entering into market under the trade name Zactima. The drug, as a tablet, can be applied to the treatment of advanced medullary thyroid cancer of adult patients.
Vandetanib is a multi-targeted tyrosine kinase inhibitor, and belongs to the Anilinoquinazoline compounds, called "second generation Iressa". It not only acts on the tumor cells, EGFR, VEGFR and RET tyrosine kinases, but can also inhibit other kind of tyrosine kinases and serine / threonine kinases. Vandetanib is the first approved drugs approved for treatment of medullary thyroid carcinoma. It is suitable for treating unresectable, locally advanced or metastatic-symptoms or progressive medullary thyroid carcinoma. A randomized, placebo-controlled clinical trial results have showed that vandetanib can significantly delay the progression time of locally advanced or metastatic medullary thyroid cancer. The recommended daily dose is 300 mg (oral), when the patient exhibits tolerance to drugs or being not able to tolerate the toxicity, they should stop treatment immediately. Those most common adverse reactions of this medicine include diarrhea, rash, acne, nausea, hypertension, headache, fatigue, loss of appetite and abdominal pain.
The adverse reactions is dose-related; at <300 mg/d, the patient has a well tolerance with the maximum tolerated dose (MTD) being 300mg. There are many kinds disease types contained in the phase clinical study. The NSCLC clinical trials of vandetanib are currently under way for China.British AstraZeneca Company, in May 2001 and October 2001, respectively, had obtained preferential access to the world's patent (WO2001032651, WO 2001074360) and applied corresponding protection on the formula, synthesis methods and pharmaceutical compositions of these compounds (including bonus salt). Vandetanib can inhibit the development of medullary thyroid carcinoma, and is the first FDA-approved drug for the treatment of the disease and will provide support for the treatment of advanced medullary thyroid cancer in adult patients. Vandetanib (INN, trade name Caprelsa) is an anti-cancer drug that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor(EGFR), and the RET-tyrosine kinase.
Vandetanib is used to treat a certain type of thyroid cancer that cannot be treated by surgery or that has spread to other parts of the body. Vandetanib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).
Vandetanib was the first drug to be approved by FDA (April 2011) for treatment of late-stage (metastatic) medullary thyroid cancer in adult patients who are ineligible for surgery. Vandetanib was first initially marketed without a trade name, and is being marketed under the trade name Caprelsa since August 2011. Vandetanib is a type of biological therapy. It is a cancer growth blocker, which stops signals (chemical messengers) that cancer cells use to divide and grow. An anticancer drug that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. Vandetanib is an orally active small molecule tyrosine kinase inhibitor (TKI) with activity against several pathways implicated in malignancy including the vascular endothelial growth factor receptor pathway, the epidermal growth factor receptor pathway, the platelet derived growth factor receptor pathway, and REarranged during Transfection pathway.
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|
Nootropic Raw Powders |
||
|
No. |
Name |
Cas no. |
|
1 |
Sunifiram |
CAS: 314728-85-3 |
|
2 |
Pirespa |
CAS: 53179-13-8 |
|
3 |
Adrafinils |
CAS: 63547-13-7 |
|
4 |
Coluracetam |
CAS: 135463-81-9 |
|
5 |
Noopept |
CAS: 157115-85-0 |
|
6 |
Piracetam |
CAS:7491-74-9 |
|
7 |
Idebenone |
CAS:58186-27-9 |
|
8 |
Carphedon |
CAS:77472-70-9 |
|
9 |
Pramiracetam |
CAS:68497-62-1 |
|
10 |
Rivastigmine |
CAS:123441-03-2 |
|
11 |
Oxiracetam |
CAS:62613-82-5 |
|
12 |
Aniracetam |
CAS:72432-10-1 |
|
13 |
Donepezil |
CAS:120014-06-4 |
|
14 |
Rivastigmine tartrate |
CAS:129101-54-8 |
|
15 |
Alpha GPC |
CAS:28319-77-9 |
|
16 |
CRL-40,941(Fladrafinil) |
CAS:90212-80-9 |
|
17 |
Fasoracetam |
CAS:110958-19-5 |
|
18 |
Galantamine |
CAS:1953-04-4 |
|
19 |
9-fluorenol |
CAS:1689-64-1 |
|
20 |
NSI-189 free base |
CAS:1270138-40-3 |
|
21 |
NSI-189 phosphate |
CAS:1270138-41-4 |
|
22 |
Phenibut |
CAS:1078-21-3 |
|
23 |
Picamilon |
CAS:62936-56-5 |
|
24 |
PRL-8-53 |
CAS:51352-87-5 |
|
25 |
Tianeptine sodium |
CAS:30123-17-2 |
|
26 |
Vinpocetine |
CAS:42971-09-5 |
|
27 |
Vincamine |
CAS:1617-90-9 |
|
28 |
Theacrine |
CAS:2309-49-1 |
|
29 |
Unifiram |
CAS: 272786-64-8 |
|
30 |
CDP Citicoline |
CAS:987-78-0 |
|
31 |
Huperzine A |
CAS:102518-79-6 |
|
32 |
brivaracetam |
CAS:357336-20-0 |
|
33 |
Etiracetam |
CAS:33996-58-6 |
|
34 |
Raubasine |
CAS:483-04-5 |
|
35 |
Entacapone |
CAS:130929-57-6 |
|
Name |
Purity |
|
Methylamine |
40% water solution |
|
Methylamine hydrochloride |
NLT 99% |
|
Benzeneacetonitrile (benzyl cyanide) |
NLT 99% |
|
Propiophenone |
NLT 99.5% |
|
Hydrogen bromide |
48% water solution |
|
(-)-Dibenzoyl-L-tartaric acid monohydrate |
NLT 99% |
|
Potassium borohydride |
NLT 97% |
|
Sodium borohydride |
NLT 98% |
|
6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (CAS No:43200-81-3) |
NLT 99% |
|
N-PHENYLPIPERIDIN-4-AMINE DIHYDROCHLORIDE (4-ANP) CAS 99918-43-1 |
NLT 99% |
|
Pramipexole Hydrochloride |
NLT 99% |
|
Albuterol sulfate |
NLT 99% |
|
Dextromethorphan hydrobromide DXM |
NLT 99% |
|
Dimethocaine |
NLT 99% |
|
Dermorphin |
10mg/vial |
|
Sunifiram DM-235 |
NLT 99% |
|
Adrafinil |
NLT 99% |
|
Armodafinil |
NLT 99% |
|
PHENIBUT |
NLT 99% |
|
Suvorexant (MK-4305) |
NLT 99% |
|
Hetlioz (tasimelteon) |
NLT 99% |
|
Amitriptyline hydrochloride |
NLT 99% |
|
Mirtazapine |
NLT 99% |
|
Trazodone hydrochloride |
NLT 99% |
|
Venlafaxine hydrochloride |
NLT 99% |
|
Bupropion hydrochloride |
NLT 99% |
|
Sertraline hydrochloride |
NLT 99% |
|
N-Methylparoxetine |
NLT 99% |
|
Paroxetine hydrochloride |
NLT 99% |
|
Fluoxetine hydrochloride |
NLT 99% |
|
Citalopram hydrobromide |
NLT 99% |
|
Vortioxetine hydrobromide |
NLT 99% |
|
Vortioxetine |
NLT 99% |
|
Tianeptine |
NLT 99% |
|
5-Hydroxytryptophan 5-HTP |
NLT 98% |
|
gamma-butyrolactone (GBL) |
NLT 99.5% |
|
5a-Hydroxy Laxogenin |
NLT 98% |
|
Testosterone Steroid |
|
|
|
No. |
CAS NO |
Name |
|
1 |
CAS:58-22-0 |
Testosterone base |
|
3 |
CAS:76-43-7 |
Fluoxymesterone Halotestin |
|
4 |
CAS:2446-23-3 |
4-Chlorodehydromethyltestosterone(Oral turinabol) |
|
5 |
CAS:1255-49-8 |
Testosterone Phenylpropionate |
|
6 |
CAS:57-85-2 |
Testosterone Propionate |
|
7 |
CAS:1045-69-8 |
Testosterone acetate |
|
8 |
CAS:315-37-7 |
Testosterone enanthate |
|
9 |
CAS:58-20-8 |
Testosterone Cypionate |
|
10 |
CAS:1424-00-6 |
Mesterolone (Proviron) |
|
11 |
CAS:5949-44-0 |
Testosterone Undecanoate |
|
12 |
CAS:15262-86-9 |
Testosterone isocaproate |
|
13 |
CAS:855-19-6 |
Turinabol(4-Chlorotestosterone/Clostebol Acetate) |
|
14 |
CAS: NO |
Testosterone Sustanon 250/100 |
|
15 |
CAS:5721-91-5 |
Testosterone decanoate |
|
16 |
CAS:58-18-4 |
Methyltestosterone (17-methyltestosterone) |
|
17 |
CAS:58-20-8 |
1-Test Cyp,Dihydroboldenone Cypionate |
|
Boldenone Steroid |
|
|
|
17 |
CAS:846-48-0 |
Boldenone |
|
18 |
CAS:13103-34-9 |
Boldenone Undecylenate (Equipoise) |
|
19 |
CAS:846-46-0 |
Boldenone Acetate |
|
20 |
CAS:13103-34-9 |
Boldenone Propionate |
|
21 |
CAS:106505-90-2 |
Boldenone Cypionate |
|
Trenbolone Steroid |
|
|
|
22 |
CAS:10161-33-8 |
Trenbolone base |
|
23 |
CAS:10161-34-9 |
Trenbolone acetate(Finaplix H/Revalor-H) |
|
24 |
CAS:472-61-546 |
Trenbolone enanthate(parabolan) |
|
25 |
CAS:23454-33-3 |
Trenbolone Hexahydrobenzyl Carbonate |
|
Nandrolone Steroid |
|
|
|
26 |
CAS:434-22-0 |
Nandrolone |
|
27 |
CAS:62-90-8 |
Nandrolone Phenypropionate (NPP)/durabolin |
|
28 |
CAS: 601-63-8 |
Nandrolone cypionate |
|
29 |
CAS:360-70-3 |
Nandrolone decanoate(DECA)/ Deca durabolin |
|
30 |
CAS: 862-89-5 |
Nandrolone Undecylate |
|
31 |
CAS: 7207-92-3 |
Nandrolone propionate |
|
Primobolan Steroid |
|
|
|
32 |
CAS:434-05-9 |
Methenolone Acetate(Primobolan) |
|
33 |
CAS:303-42-4 |
Methenolone enanthate (USAN) |
|
34 |
CAS: 153-00-4 |
Metenolone |
|
35 |
CAS:3381-88-2 |
Superdrol Powder/Methasterone (methyl-drostanolone) |
|
36 |
CAS:521-12-0 |
Drostanolone Propionate (Masteron) |
|
37 |
CAS:472-61-145 |
Drostanolone Enanthate(Masteron) |
|
Anabolic Steroids |
|
|
|
38 |
CAS:72-63-9 |
Methandrostenolone (Dianabol, methandienone) |
|
39 |
CAS:3704-09-4 |
Mibolerone |
|
40 |
CAS:965-93-5 |
Methyltrienolone (Metribolone) |
|
41 |
CAS:5197-58-0 |
Methylstenbolone |
|
42 |
CAS: 5630-53-5 |
Tibolone |
|
43 |
CAS:521-11-9 |
Mestanolone |
|
44 |
CAS:521-18-6 |
Stanolone (androstanolone) |
|
45 |
CAS:434-07-1 |
Oxymetholone (Anadrol) |
|
46 |
CAS:53-39-4 |
Oxandrolone(Anavar) |
|
47 |
CAS:10418-03-8 |
stanozolol(Winstrol) |
|
48 |
CAS:6157-87-5 |
Trestolone acetate |
|
49 |
CAS:853-23-6 |
Dehydroisoandrosterone 3-acetate |
|
50 |
CAS:53-43-0 |
Dehydroepiandrosterone (DHEA) |
|
51 |
CAS:481-29-8 |
Epiandrosterone |
|
52 |
CAS:566-19-8 |
7-Keto-dehydroepiandrosterone |
|
53 |
CAS:76822-24-7 |
1-DHEA |
|
Testosterone Acetate |
Trenbolone Acetate |
MGF |
|
Testosterone Cypionate |
Trenbolone Enanthate |
PEG MGF |
|
Testosterone Decanoate |
Boldenone Acetate |
CJC-1295 |
|
Testosterone Enanthate |
Boldenone undecylenate |
CJC-1295 DAC |
|
Testosterone Isocaproate |
Boldenone Cypionate |
PT-141 |
|
Testosterone Phenylpropionate |
Boldenone Propionate |
Melanotan-1 |
|
Testosterone Propionate |
Nandrolone Decanoate |
Melanotan-2 |
|
Testosterone Undecanoate |
Nandrolone phenylpropionate |
GHRP-2 |
|
Mesterone |
Nandrolone undecylate |
GHRP-6 |
|
Testosterone Sustanon 250 |
Nandrolone cypionate |
Ipamorelin |
|
Clostebol Acetate |
Nandrolone propionate |
Hexarelin |
|
Methylandrostanolone |
Methyltrienolone |
Sermorelin |
|
Methenolone Enanthate |
Drostanolone Propionate |
Oxytocin |
|
Methenolone Acetate |
Drostanolone Enanthate |
TB500 |
|
Anadrol |
Stanolone |
Fragment 176-191 |
|
Anavar |
Tadalafil |
Triptorelin |
|
Winstrol |
Vardenafil |
Tesamorelin |
|
Clomifene citrate |
Dianabol |
Gonadorelin |
|
Toremifene citrate |
Tamoxifen Citrate |
DSIP |
|
Finasteride |
hydrochloride |
Selank |
|
Benzocaine |
Liothyronine sodium T3 |
L-Carnitine |
