Aicar SarmPharmaceutical Raw Materials , Steroid Hormones Bodybuilding CAS 2627-69-2

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 2627-69-2
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 1000kg per month
Product Name: AICAR EINECS: 220-097-5
CAS: 2627-69-2 MF: C9H14N4O5
MW: 258.23 Appearance: Tan Powder
High Light:

pharmaceutical active ingredients

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pharmaceutical anabolic steroids

Pharmaceutical Raw Material AICAR / ACADESINE Popular Bodybuilding Supplement Aicar Sarms Powder

 

Quick Details:

 

 

Product Name

 

Aicar

 

Alias

 

Acadesine

 

CAS

 

2627-69-2

 

Molecular Formula

 

C9H14N4O5

 

Molecular weight

 

258.23

 

Apperance

 

Off-White Powder

 

Assay

 

99%min

 

Usage

 

Pharmaceutical intermediates. For the treatment of cardiovascular diseases

 

Delivery

 

DHL,EMS,FedEx,TNT,UPS,etc.



Applications:

 

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

COA :

 

 

Item

 

Specification

Result

 

Appearance

 

White powder

Complies

 

Related substance (HPLC)

 

Total impurity ≤0.5%
Max single impurity ≤0.1%

0.2%
0.06%

 

Odor

 

Characteristic

Complies

 

Assay

 

99%

99.8%

 

Sieve analysis

 

100% pass 80 mesh

Complies

 

Loss on Drying
Residue on Ignition

 

≤1.0%
≤1.0%

0.12%
0.09%

 

Heavy Metal

 

<10ppm

Complies

 

As

 

<0.1ppm

0.05ppm

 

Pb

 

<0.1ppm

0.05ppm

 

Cd

 

<0.1ppm

0.05ppm

 

Residual Solvents

 

<100ppm

Complies

 

Residual Pesticide

 

Negative

Complies

 

Total Plate Count

 

<1000cfu/g

Complies

 

Yeast & Mold

 

<100cfu/g

Complies

 

E.Coli

 

Negative

Complies

 

Salmonella

 

Negative

Complies

 

 

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Our Service

Fast Delivery

Delivery within 24 hours upon receipt of your payment

Quality

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Payment Terms

T/T Bank Transfer, Western Union, Bitcoin and MoneyGram Available

Sample

Sample available at any time

Tracking your order at any time

Inform your order's further new situation at any time

Package

Professional packing with professional materials

 

 

Aicar SarmPharmaceutical Raw Materials , Steroid Hormones Bodybuilding CAS 2627-69-2 0

Contact Details
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