Product Name: Tretinoin

Product Details:

Product: Tretinoin
Other name: Vitamin A Acid, Retinoids
Chemical name for (13 E)-3, 7-two methyl-9-(2,6,6-three methyl ring has alkenyl)-2,4,6,8-I arachidonic acid.
CAS: 302-79-4
EINECS: 206-129-0
MF.: C20H28O2
MW.: 300.44
Metaling point : 179-184 ºC
Spec: USP28
Appearance: light yellow or orange crystal powder d A acid
 

Description:

Tretinoin is commonly used in dermatology drugs, which is the department of vitamin A (Victoria methanol) metabolic intermediates.It mainly affects the growth of bones and epithelial metabolism, can promote epithelial cell proliferation and updates, and can inhibit the proliferation and differentiation of keratinocytes, so hyperkeratosis can be back to normal. Therefore many complete or incomplete keratosis, hyperkeratosis of diseases have a certain therapeutic effect, treat a variety of skin diseases. The use of the drug can penetrate topical skin quickly, enable significantly increased epithelial cell turnover. This class of drugs has strong and rapid inhibition on the secretion of the sebaceous glands, can reduce sebum secretion. In addition, the product also has anti-tumor, promote wound healing and anti-inflammatory effects. It is a yellow needle crystal, with a similar smell of vitamin acetate. Soluble in methanol, ethanol, acetone, also in vegetable oil and fatty. In case of light, it is thermal instability, suck up moisture in the air, polymerization and metamorphism in water. The melting point of all trans-vitamin A acid is 182 ~ 180°C, the melting range of which is mixed with a small amount of isomers is 170 ~ 190°C. This product can induce epidermal hyperplasia, and improve the granular layer and the cell layer thickness.It can influence the silk protein process and the formation of cross-linked film and promote the differentiation of epidermal granular layer cells in the late stage of the differentiation of the epidermal cells by affecting K10, K1 keratin solution.

It main manifestations of inflammatory response, regulation of growth and differentiation of epidermal cells, promote collagen production, improve the function of sebaceous glands, reversing light aging, inhibit melanin production promote cuticle thickening. Tretinoin should be fully protected from light during all handling. Solutions are unstable in the presence of strong oxidizers.

Application:

Used in abnormal acne, ichthyosis and abnormal type of psoriasis. For the treatment of acne vulgaris, psoriasis, ichthyosis, lichen planus, Mao Fahong rosea, follicular keratosis, squamous cell carcinoma and melanoma, disease. Pharmacology: Epidermal keratinocytes, dermal melanin cells and fibroblasts are the target cells of A retinoic acid important. A retinoic acid can affect the formation of melanin melanin cells, its role is more than point, has inhibitory effect on tyrosine hydroxylase, Doba oxidase and two hydroxyindole oxidase three catalytic activity, thereby reducing the formation of melanin, reduce skin pigmentation.

The strains of metabolic intermediate of vitamin A , mainly affecting bone growth and promote epithelial cell proliferation , differentiation, metabolism horny dissolution . For the treatment of acne vulgaris, psoriasis , ichthyosis , lichen planus , pityriasis rubra pilaris , follicular keratosis , squamous cell carcinoma and melanoma and other diseases. Vitamin A acid , is unanimously respected by the mainstream dermatological ingredients , one of the two ace dermatology drugs , mainly for acne and skin aging are two problems . Because doing well, A acid gradually become daily care products from medical drugs. Mainly inflammatory response , regulating the growth and differentiation of epidermal cells , and promote collagen production, improving sebaceous gland function , reversal of photoaging , inhibit melanin production , and so promote the thickening of the dermis
Dosage and oral , 10mg / times , 2 to 3 times / day. Topical, 0.05% to 0.1% cream or ointment. Partial erasure , 1 to 2 times / day.

Function:

1. Used for usual acne, lichen planus, white spot, hair red pityriasis and facial pityriasis simplex
2. Also can be used as an auxiliary therapy for psoriasis.
3. Can also be used in the treatment of multiple verruca vulgaris, and abnormal keratinization of various skin
diseases such as ichthyosis, hair follicle keratinization disorder
4. For cancer prevention and treatment of precancerous lesions, Such as white spot of the oral mucosa, laryngeal
papilloma, stunting disease
5. Used for skin malignant tumor such as squamous cell carcinomas and basal cell carcinoma, mycosis enzyme disease
6. For acute early young granulocyte leukemia.

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